Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP+-induced apoptosis of dopaminergic neuronal cells.
Teng L1, Kou C2, Lu C1, Xu J3, Xie J1, Lu J1, Liu Y1, Wang Z1, Wang D1.
International journal of molecular medicine.Int J Mol Med.2014 Sep;34(3):742-8. doi: 10.3892/ijmm.2014.1830. Epub 2014 Jul 2.
Glycyrrhizic acid (GA), a major compound separated from Radix Glycyrrhizae, has been shwon to exert various biochemical effects, including neuroprotective effects. In the present study, we investigated the protective effects of GA against 1-methyl-4-phenylpyridinium (MPP+)‑induced damage to diff
Comparative pharmacokinetic study of four major components after oral administration of pure compounds, herbs and Si-Ni-San to rats.
Wen J1, Wang Y, Yang L, Zheng W, Zhao L, Li F.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2014 Sep;44(9):855-860. Epub 2014 Mar 18.
Abstract 1. The pharmacokinetic differences of paeoniflorin, naringin, naringenin and glycyrrhetinic acid (GA) following oral administration of pure compounds, single herbs and Si-Ni-San (SNS) decoction to rats were studied. Blood samples were analyzed with a validated UPLC-MS/MS method. Student's
Pharmacokinetic study of multiple active constituents from Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS.
Wang Q1, Shi L1, Tang X1, Wang Q1, Dang X1, Zhang Y2.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 Aug 15;965:19-26. doi: 10.1016/j.jchromb.2014.05.038. Epub 2014 Jun 8.
Kushen-Gancao Decoction (KGD) is a classic traditional Chinese herb combination in treating viral hepatitis and chronic liver diseases. This study aims to investigate the pharmacokinetic (PK) study of matrine (MT), oxymatrine (OMT), glycyrrhizic acid (GL) and glycyrrhetinic acid (GA) following oral