WordNet
- a substance that exerts some force or effect
- a businessman who buys or sells for another in exchange for a commission (同)factor, broker
- any agent or representative of a federal agency or bureau (同)federal agent
- a representative who acts on behalf of other persons or organizations
- an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
- how long something has existed; "it was replaced because of its age"
- a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
- begin to seem older; get older; "The death of his wife caused him to age fast"
- make older; "The death of his child aged him tremendously"
- an encapsulated neural structure consisting of a collection of cell bodies or neurons
- the act of obstructing or deflecting someones movements (同)block
PrepTutorEJDIC
- 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
- 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる
- 神経節・ガングリオン，結節腫 《主に手首にできる良性の嚢腫(のうしゆ)》・〔知的･産業的活動の〕中心，中枢 〔of〕
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- 1. 成人における迅速導入気管挿管のための神経筋遮断剤（NMBA） neuromuscular blocking agents nmba for rapid sequence intubation in adults
- 2. 重症患者における神経筋遮断剤の使用 use of neuromuscular blocking medications in critically ill patients
- 3. 神経筋接合部に作用する毒素の概要 overview of neuromuscular junction toxins
- 4. 有機リン剤およびカルバメート中毒 organophosphate and carbamate poisoning
- 5. 救急外来における急性の筋力低下を訴える成人の評価 evaluation of the adult with acute weakness in the emergency department
English Journal
- Molecular interactions between mecamylamine enantiomers and the transmembrane domain of the human α4β2 nicotinic receptor.
- Bondarenko V1, Targowska-Duda KM, Jozwiak K, Tang P, Arias HR.Author information 1Department of Anesthesiology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15213, United States.AbstractTo characterize the binding sites of mecamylamine enantiomers on the transmembrane domain (TMD) of human (h) (α4)3(β2)2 and (α4)2(β2)3 nicotinic acetylcholine receptors (AChRs), we used nuclear magnetic resonance (NMR), molecular docking, and radioligand binding approaches. The interactions of (S)-(+)- and (R)-(-)-mecamylamine with several residues, determined by high-resolution NMR, within the hα4β2-TMD indicate different modes of binding at several luminal (L) and nonluminal (NL) sites. In general, the residues sensitive to each mecamylamine enantiomer are similar at both receptor stoichiometries. However, some differences were observed. The molecular docking experiments were crucial for delineating the location and orientation of each enantiomer in its binding site. In the (α4)2(β2)3-TMD, (S)-(+)-mecamylamine interacts with the L1 (i.e., between positions -3' and -5') and L2 (i.e., between positions 16' and 20') sites, whereas the β2-intersubunit (i.e., cytoplasmic end of two β2-TMDs) and α4/β2-intersubunit (i.e., cytoplasmic end of α4-TM1 and β2-TM3) sites are shared by both enantiomers. In the (α4)3(β2)2-TMD, both enantiomers bind with different orientations to the L1' (closer to ring 2') and α4-intrasubunit (i.e., at the cytoplasmic ends of α4-TM1 and α4-TM2) sites, but only (R)-(-)-mecamylamine interacts with the L2' (i.e., closer to ring 20') and α4-TM3-intrasubunit sites. Our findings are important because they provide, for the first time, a structural understanding of the allosteric modulation elicited by mecamylamine enantiomers at each hα4β2 stoichiometry. This advancement could be beneficial for the development of novel therapies for the treatment of several neurological disorders.
- Biochemistry.Biochemistry.2014 Feb 11;53(5):908-18. doi: 10.1021/bi400969x. Epub 2014 Jan 30.
- To characterize the binding sites of mecamylamine enantiomers on the transmembrane domain (TMD) of human (h) (α4)3(β2)2 and (α4)2(β2)3 nicotinic acetylcholine receptors (AChRs), we used nuclear magnetic resonance (NMR), molecular docking, and radioligand binding approaches. The interactions of (
- PMID 24437521
- Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision.
- Mauss AS1, Meier M, Serbe E, Borst A.Author information 1Max-Planck-Institute of Neurobiology, 82152 Martinsried, Germany.AbstractVisual systems extract directional motion information from spatiotemporal luminance changes on the retina. An algorithmic model, the Reichardt detector, accounts for this by multiplying adjacent inputs after asymmetric temporal filtering. The outputs of two mirror-symmetrical units tuned to opposite directions are thought to be subtracted on the dendrites of wide-field motion-sensitive lobula plate tangential cells by antagonistic transmitter systems. In Drosophila, small-field T4/T5 cells carry visual motion information to the tangential cells that are depolarized during preferred and hyperpolarized during null direction motion. While preferred direction input is likely provided by excitation from T4/T5 terminals, the origin of null direction inhibition is unclear. Probing the connectivity between T4/T5 and tangential cells in Drosophila using a combination of optogenetics, electrophysiology, and pharmacology, we found a direct excitatory as well as an indirect inhibitory component. This suggests that the null direction response is caused by feedforward inhibition via yet unidentified neurons.
- The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Feb 5;34(6):2254-63. doi: 10.1523/JNEUROSCI.3938-13.2014.
- Visual systems extract directional motion information from spatiotemporal luminance changes on the retina. An algorithmic model, the Reichardt detector, accounts for this by multiplying adjacent inputs after asymmetric temporal filtering. The outputs of two mirror-symmetrical units tuned to opposite
- PMID 24501364
- Aging enhances autonomic support of blood pressure in women.
- Barnes JN1, Hart EC, Curry TB, Nicholson WT, Eisenach JH, Wallin BG, Charkoudian N, Joyner MJ.Author information 1Department of Anesthesiology, Mayo Clinic, 200 1st St SW, SMH, Joseph 4-184, Rochester, MN 55905. Barnes.Jill@mayo.edu.AbstractThe autonomic nervous system plays a central role in both acute and chronic blood pressure regulation in humans. The activity of the sympathetic branch of the autonomic nervous system is positively associated with peripheral resistance, an important determinant of mean arterial pressure in men. In contrast, there is no association between sympathetic nerve activity and peripheral resistance in women before menopause, yet a positive association after menopause. We hypothesized that autonomic support of blood pressure is higher after menopause in women. We examined the effect of ganglionic blockade on arterial blood pressure and how this relates to baseline muscle sympathetic nerve activity in 12 young (25±1 years) and 12 older postmenopausal (61±2 years) women. The women were studied before and during autonomic blockade using trimethaphan camsylate. At baseline, muscle sympathetic nerve activity burst frequency and burst incidence were higher in the older women (33±3 versus 15±1 bursts/min; 57±5 versus 25±2 bursts/100 heartbeats, respectively; P<0.05). Muscle sympathetic nerve activity bursts were abolished by trimethaphan within minutes. Older women had a greater decrease in mean arterial pressure (-29±2 versus -9±2 mm Hg; P<0.01) and total peripheral resistance (-10±1 versus -5±1 mm Hg/L per minute; P<0.01) during trimethaphan. Baseline muscle sympathetic nerve activity was associated with the decrease in mean arterial pressure during trimethaphan (r=-0.74; P<0.05). In summary, our results suggest that autonomic support of blood pressure is greater in older women compared with young women and that elevated sympathetic nerve activity in older women contributes importantly to the increased incidence of hypertension after menopause.
- Hypertension.Hypertension.2014 Feb;63(2):303-8. doi: 10.1161/HYPERTENSIONAHA.113.02393. Epub 2013 Dec 9.
- The autonomic nervous system plays a central role in both acute and chronic blood pressure regulation in humans. The activity of the sympathetic branch of the autonomic nervous system is positively associated with peripheral resistance, an important determinant of mean arterial pressure in men. In c
- PMID 24324040
Japanese Journal
- カーボン線維電極による交感神経活動計測
- 堀内 邦雄,青木 和夫,野尻 知里
- ライフサポート = / the Society of Life Support Technology [編] 10(4), 12-17, 1998-12-30
- … Relationship of heart rate and integrated renal sympathetic nerve activity(IRSNA)was shown quantitatively by recording vital reaction at administration of ganglionic-blocking agent. …
- NAID 10031134023
- バイ(海つぼ)毒素に関する研究
- 小菅 卓夫,全田 浩,辻 邦郎
- 藥學雜誌 107(9), 665-675, 1987-09-25
- … Pharmacological studies suggested that the toxins have selective affinity for ganglionic nicotine receptors, its affinity constant for these receptors being more than three orders of magnitude greater than that of hexamethonium. …
- NAID 110003649810
- Characterization of neurohormonal changes following the production of the benign and malignant phases of two-kidney, two-clip Goldblatt hypertension.
- , , ,
- Japanese Heart Journal 28(3), 413-426, 1987
- … Administration of angiotensin I converting enzyme inhibitor (SQ 14225) reduced the blood pressure both in the benign and malignant phases of 2K2C renovascular hypertension, and a ganglionic blocking agent (hexamethonium) also decreased the blood pressure. …
- NAID 130000764882
Related Links
- agent (a´jent) something capable of producing an effect. adrenergic blocking agent one that inhibits response to sympathetic impulses by blocking the alpha (alpha-adrenergic blocking a.) or beta (beta-adrenergic blocking a.) receptor ...
- Ganglionic blocking agent definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Added to Favorites Dictionary Thesaurus Word Dynamo Quotes Reference Translator n. ...
Related Pictures
★リンクテーブル★
| リンク元 | 「自律神経節遮断薬」「ganglion blocker」「ganglionic blocker」 |
| 関連記事 | 「agent」「age」「ganglionic」「blocking agent」 |
「自律神経節遮断薬」
- 英
- autonomic ganglionic blocker, ganglionic blocking agents,
- 同
- 神経節遮断薬、ganglion-blocking agent、ganglionic blocking agent、ganglionic blocker、gangliolytic
- 関
- 節遮断薬、自律神経
「ganglion blocker」
「ganglionic blocker」
「agent」
- n.
- 代行者、代理人。代理業者
- 政府職員、官吏
- ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、～剤。病原体
- 関
- agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle
「age」
- n.
- 年齢、歳
- v.
- 加齢する、熟成する
「ganglionic」
- adj.
- 神経節の、節の