- 同
- FGFR3
WordNet
- cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
- come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
- become attached by or as if by the process of growth; "The tree trunks had grown together"
- become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
- cause to grow or develop; "He grows vegetables in his backyard"
- increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
- (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
- (pathology) an abnormal proliferation of tissue (as in a tumor)
- a progression from simpler to more complex forms; "the growth of culture"
- something grown or growing; "a growth of hair"
- vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
- 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/20 03:28:25」(JST)
[Wiki en表示]
| Fibroblast growth factor receptor 3 |
|
Rendering of 1ry7
|
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1RY7, 2LZL, 4K33
|
|
|
| Identifiers |
| Symbols |
FGFR3 ; ACH; CD333; CEK2; HSFGFR3EX; JTK4 |
| External IDs |
OMIM: 134934 MGI: 95524 HomoloGene: 55437 ChEMBL: 2742 GeneCards: FGFR3 Gene |
| EC number |
2.7.10.1 |
| Gene ontology |
| Molecular function |
• protein tyrosine kinase activity
• fibroblast growth factor-activated receptor activity
• protein binding
• ATP binding
• fibroblast growth factor binding
|
| Cellular component |
• extracellular region
• lysosome
• endoplasmic reticulum
• Golgi apparatus
• plasma membrane
• integral component of plasma membrane
• focal adhesion
• cytoplasmic side of plasma membrane
• transport vesicle
• perinuclear region of cytoplasm
|
| Biological process |
• negative regulation of transcription from RNA polymerase II promoter
• MAPK cascade
• skeletal system development
• positive regulation of endothelial cell proliferation
• endochondral ossification
• morphogenesis of an epithelium
• chondrocyte differentiation
• lens morphogenesis in camera-type eye
• endochondral bone growth
• epidermal growth factor receptor signaling pathway
• JAK-STAT cascade
• positive regulation of cell proliferation
• negative regulation of cell proliferation
• insulin receptor signaling pathway
• fibroblast growth factor receptor signaling pathway
• positive regulation of phospholipase activity
• peptidyl-tyrosine phosphorylation
• substantia nigra development
• central nervous system myelination
• bone mineralization
• forebrain development
• positive regulation of protein ubiquitination
• somatic stem cell maintenance
• chondrocyte proliferation
• Fc-epsilon receptor signaling pathway
• positive regulation of tyrosine phosphorylation of Stat1 protein
• positive regulation of tyrosine phosphorylation of Stat3 protein
• positive regulation of MAPK cascade
• positive regulation of neuron apoptotic process
• positive regulation of phosphatidylinositol 3-kinase activity
• innate immune response
• positive regulation of cell differentiation
• negative regulation of mitotic nuclear division
• negative regulation of smoothened signaling pathway
• protein autophosphorylation
• neurotrophin TRK receptor signaling pathway
• phosphatidylinositol-mediated signaling
• digestive tract morphogenesis
• negative regulation of developmental growth
• response to axon injury
• negative regulation of astrocyte differentiation
• inner ear receptor cell differentiation
• bone morphogenesis
• axonogenesis involved in innervation
• alveolar secondary septum development
• lens fiber cell development
• positive regulation of ERK1 and ERK2 cascade
• bone maturation
• epithelial cell fate commitment
• positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
• cochlea development
• positive regulation of canonical Wnt signaling pathway
• fibroblast growth factor receptor apoptotic signaling pathway
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
2261 |
14184 |
| Ensembl |
ENSG00000068078 |
ENSMUSG00000054252 |
| UniProt |
P22607 |
E9QNJ9 |
| RefSeq (mRNA) |
NM_000142 |
NM_001163215 |
| RefSeq (protein) |
NP_000133 |
NP_001156687 |
| Location (UCSC) |
Chr 4:
1.79 – 1.81 Mb |
Chr 5:
33.72 – 33.74 Mb |
| PubMed search |
[1] |
[2] |
|
|
Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene.[1] FGFR3 has also been designated as CD333 (cluster of differentiation 333).
Contents
- 1 Structure and function
- 2 Disease linkage
- 3 Interactions
- 4 See also
- 5 References
- 6 Further reading
- 7 External links
Structure and function
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals which ultimately influencing cell mitogenesis and differentiation.
This particular family member binds both acidic and basic fibroblast growth factor and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia (Osteochondrodysplasia). Alternative splicing occurs and additional variants have been described, including those utilizing alternate exon 8 rather than 9, but their full-length nature has not been determined.[2]
Disease linkage
Defects in the FGFR3 gene has been associated with several conditions, including:
- achondroplasia/hypochondroplasia
- thanatophoric dwarfism
- seborrheic keratosis[3]
- bladder cancer[4]
- craniosynostosis[5]
Interactions
Fibroblast growth factor receptor 3 has been shown to interact with FGF1[6][7] and FGF9.[6][7]
See also
- Cluster of differentiation
- Fibroblast growth factor receptor
References
- ^ Keegan K, Johnson DE, Williams LT, Hayman MJ (Mar 1991). "Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3". Proc Natl Acad Sci U S A 88 (4): 1095–9. doi:10.1073/pnas.88.4.1095. PMC 50963. PMID 1847508.
- ^ "Entrez Gene: FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)".
- ^ Hafner C, Hartmann A, Vogt T (2007). "FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin". J. Invest. Dermatol. 127 (7): 1572–3. doi:10.1038/sj.jid.5700772. PMID 17568799.
- ^ Lamy A, Gobet F, Laurent M et al. (2006). "Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations". J. Urol. 176 (6 Pt 1): 2686–9. doi:10.1016/j.juro.2006.07.132. PMID 17085196.
- ^ Mulliken, JB (Nov 1999). "Molecular diagnosis of bilateral coronal synostosis". Plast Reconstr Surg. 104 (6): 1603–1615. PMID 10541159. Retrieved 30 October 2014.
- ^ a b Santos-Ocampo, S; Colvin J S; Chellaiah A; Ornitz D M (Jan 1996). "Expression and biological activity of mouse fibroblast growth factor-9". J. Biol. Chem. (UNITED STATES) 271 (3): 1726–31. doi:10.1074/jbc.271.3.1726. ISSN 0021-9258. PMID 8576175.
- ^ a b Chellaiah, A; Yuan W; Chellaiah M; Ornitz D M (Dec 1999). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". J. Biol. Chem. (UNITED STATES) 274 (49): 34785–94. doi:10.1074/jbc.274.49.34785. ISSN 0021-9258. PMID 10574949.
Further reading
- Schweitzer DN, Graham JM, Lachman RS et al. (2001). "Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3.". Am. J. Med. Genet. 98 (1): 75–91. doi:10.1002/1096-8628(20010101)98:1<75::AID-AJMG1010>3.0.CO;2-6. PMID 11426459.
- Horton WA, Lunstrum GP (2003). "Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism.". Reviews in endocrine & metabolic disorders 3 (4): 381–5. PMID 12424440.
- Bonaventure J, Silve C (2006). "[Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways]". Med Sci (Paris) 21 (11): 954–61. doi:10.1051/medsci/20052111954. PMID 16274647.
- Hernández S, Toll A, Baselga E et al. (2007). "Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors.". J. Invest. Dermatol. 127 (7): 1664–6. doi:10.1038/sj.jid.5700705. PMID 17255960.
- Olsen SK et al. (2004). "Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.". Pnas USA 101 (4): 935–40. doi:10.1073/pnas.0307287101. PMC 327120. PMID 14732692.
|
PDB gallery
|
|
|
|
|
1ry7: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
|
|
|
|
External links
- GeneReviews/NIH/NCBI/UW entry on FGFR-Related Craniosynostosis Syndromes
- GeneReviews/NIH/NCBI/UW entry on Muenke Syndrome
- GeneReviews/NIH/NCBI/UW entry on Achondroplasia
- GeneReviews/NIH/NCBI/UW entry on Hypochondroplasia
- GeneReviews/NIH/NCBI/UW entry on Thanatophoric Dysplasia
- FGFR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
Protein kinases: tyrosine kinases (EC 2.7.10)
|
|
|
Receptor tyrosine kinases (EC 2.7.10.1)
|
|
| Growth factor receptors |
| EGF receptor family |
|
|
| Insulin receptor family |
|
|
| PDGF receptor family |
- CSF1R
- FLT3
- KIT
- PDGFR (PDGFRA
- PDGFRB)
|
|
| FGF receptor family |
|
|
| VEGF receptors family |
|
|
| HGF receptor family |
|
|
| Trk receptor family |
|
|
|
| EPH receptor family |
- EPHA1
- EPHA2
- EPHA3
- EPHA4
- EPHA5
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB5
- EPHB6
- EPHX
|
|
| LTK receptor family |
|
|
| TIE receptor family |
|
|
| ROR receptor family |
|
|
| DDR receptor family |
|
|
| PTK7 receptor family |
|
|
| RYK receptor family |
|
|
| MuSK receptor family |
|
|
| ROS receptor family |
|
|
| AATYK receptor family |
|
|
| AXL receptor family |
|
|
| RET receptor family |
|
|
| uncatagorised |
|
|
|
|
|
Non-receptor tyrosine kinases (EC 2.7.10.2)
|
|
| ABL family |
|
|
| ACK family |
|
|
| CSK family |
|
|
| FAK family |
|
|
| FES family |
|
|
| FRK family |
|
|
| JAK family |
|
|
| SRC-A family |
|
|
| SRC-B family |
|
|
| TEC family |
|
|
| SYK family |
|
|
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Receptors: growth factor receptors
|
|
| Type I cytokine receptor |
- Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
|
|
| Receptor protein serine/threonine kinase |
- TGF pathway: TGF-beta
- Activin
- Bone morphogenetic protein
|
|
| Receptor tyrosine kinase |
|
|
|
- Nerve growth factors: high affinity Trk
|
|
|
|
|
- Somatomedin
- Insulin-like growth factor 1
|
|
- ErbB/Epidermal growth factor
|
|
|
|
|
|
| Tumor necrosis factor receptor |
- Nerve growth factors: Low affinity/p75
|
|
| Ig superfamily |
- Platelet-derived growth factor
- Stem cell factor
|
|
| Other/ungrouped |
- Somatomedin
- Insulin-like growth factor 2
|
|
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Outcomes of a bladder cancer screening program using home hematuria testing and molecular markers.
- Bangma CH, Loeb S, Busstra M, Zhu X, El Bouazzaoui S, Refos J, Van Der Keur KA, Tjin S, Franken CG, van Leenders GJ, Zwarthoff EC, Roobol MJ.SourceDepartment of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands.
- European urology.Eur Urol.2013 Jul;64(1):41-7. doi: 10.1016/j.eururo.2013.02.036. Epub 2013 Mar 4.
- BACKGROUND: We previously reported the preliminary findings from a feasibility study of bladder cancer (BCa) screening with urinary molecular markers (Bladder Cancer Urine Marker Project [BLU-P]) that has now been terminated.OBJECTIVE: To report the final results from BLU-P to determine whether mass
- PMID 23478169
- Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.
- Majewski IJ, Mittempergher L, Davidson NM, Bosma A, Willems SM, Horlings HM, de Rink I, Greger L, Hooijer GK, Peters D, Nederlof PM, Hofland I, de Jong J, Wesseling J, Kluin RJ, Brugman W, Kerkhoven R, Nieboer F, Roepman P, Broeks A, Muley TR, Jassem J, Niklinski J, van Zandwijk N, Brazma A, Oshlack A, van den Heuvel M, Bernards R.SourceDivision of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Division of Cancer and Haematology, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia.
- The Journal of pathology.J Pathol.2013 Jul;230(3):270-6. doi: 10.1002/path.4209.
- Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic approaches required to identify these events are struggling to keep pace with the diverse array of genetic alterations that occur in cancer. Diagnosti
- PMID 23661334
- The Pathogenic A391E Mutation in FGFR3 Induces a Structural Change in the Transmembrane Domain Dimer.
- Mudumbi KC, Julius A, Herrmann J, Li E.SourceDepartment of Biology, Saint Joseph's University, Philadelphia, PA, 19107, USA.
- The Journal of membrane biology.J Membr Biol.2013 Jun;246(6):487-93. doi: 10.1007/s00232-013-9563-6. Epub 2013 Jun 1.
- Fibroblast growth factor receptor 3 (FGFR3) is a single-pass membrane protein and a member of the receptor tyrosine kinase family of proteins that is involved in the regulation of skeletal growth and development. FGFR3 has three distinct domains: the ligand binding extracellular domain, the cytosoli
- PMID 23727984
Japanese Journal
- Roles of FGF20 in dopaminergic neurons and Parkinson's disease.
- Itoh Nobuyuki,Ohta Hiroya
- Frontiers in molecular neuroscience 6, 2013-05
- … The fibroblast growth factor (FGF) family comprises 22 members with diverse functions in development and metabolism. … Fgf20, which acts on proximal cells, significantly enhanced the survival of cultured dopaminergic neurons by activating the mitogen-activated protein kinase (MAPK) pathway through Fgf receptor 1c. …
- NAID 120005289845
- The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans
- Ishigami Takeshi,Hida Yasutoshi,Matsudate Yoshihiro,Murao Kazutoshi,Kubo Yoshiaki
- The journal of medical investigation : JMI 60(1-2), 106-113, 2013-02
- … Fibroblast growth factors (FGFs) and their receptors (FGFRs) control a wide range of biological functions ; …
- NAID 120005380904
- Prostaglandin D2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor
- Ayabe Shinya,Kida Taiki,Hori Masatoshi,Ozaki Hiroshi,Murata Takahisa
- Journal of Pharmacological Sciences 121(4), 312-317, 2013
- … Pretreatment with PGD2 (0.1 - 10 μM, 1 h) significantly attenuated type I collagen secretion to the cell supernatant induced by transforming growth factor-β (TGF-β). … Although an agonist on chemoattractant receptorhomologous molecule expressed on Th2 cells (CRTH2) did not have any effect, the prostanoid DP-receptor agonist BW245C (0.01 - 1 μM) suppressed TGF-β-induced collagen secretion. …
- NAID 130003382584
Related Links
- TEXT Description Fibroblast growth factors (FGFs; see 131220) are a family of polypeptide growth factors involved in a variety of activities, including ...
- fibroblast growth-factor receptor-3 One of the three (FGFR3a, FGFR3b, FGFR3c) mitogenic signalling molecules with roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. They are up ...
★リンクテーブル★
[★]
- 同
- fibroblast growth factor receptor 3
[★]
- (過去: grew-過去分詞: grown)
- 関
- extend、growth、outgrow、outgrowth、stretch
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
線維芽細胞
- 同
- fibroblasts, scleroderma phenotype
[★]