WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition.

Schmidt B1, Wei L1, DePeralta DK1, Hoshida Y2, Tan PS2,3, Sun X2, Sventek JP1, Lanuti M4, Tanabe KK1, Fuchs BC1.
International journal of cancer.Int J Cancer.2016 Mar 15;138(6):1494-505. doi: 10.1002/ijc.29893. Epub 2015 Nov 9.
A recent gene expression classification of hepatocellular carcinoma (HCC) includes a poor survival subclass termed S2 representing about one-third of all HCC in clinical series. S2 cells express E-cadherin and c-myc and secrete AFP. As the expression of fibroblast growth factor receptors (FGFRs) dif
PMID 26481559

Oncogene and therapeutic target analyses in Atypical fibroxanthomas and pleomorphic dermal sarcomas.

Helbig D1, Ihle MA2, Pütz K2, Tantcheva-Poor I1, Mauch C1, Büttner R2, Quaas A2.
Oncotarget.Oncotarget.2016 Mar 2. doi: 10.18632/oncotarget.7845. [Epub ahead of print]
BACKGROUND: Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS.MATERIALS AND METHODS: We performed the world-wide most comprehensive immunohistoche
PMID 26943575

Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations.

Ross JS1,2, Wang K2, Khaira D2, Ali SM2, Fisher HA1, Mian B1, Nazeer T1, Elvin JA2, Palma N2, Yelensky R2, Lipson D2, Miller VA2, Stephens PJ2, Subbiah V3, Pal SK4.
Cancer.Cancer.2016 Mar 1;122(5):702-11. doi: 10.1002/cncr.29826. Epub 2015 Dec 9.
BACKGROUND: In the current study, the authors present a comprehensive genomic profile (CGP)-based study of advanced urothelial carcinoma (UC) designed to detect clinically relevant genomic alterations (CRGAs).METHODS: DNA was extracted from 40 µm of formalin-fixed, paraffin-embedded sections from
PMID 26651075

FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line

Li Minqi,Seki Yukie,Freitas Paulo H. L.,Nagata Masaki,Kojima Taku,Sultana Sara,Ubaidus Sobhan,Maeda Takeyasu,Shimomura Junko,Henderson Janet E.,Tamura Masato,Oda Kimimitsu,Liu Zhusheng,Guo Ying,Suzuki Reiko,Yamamoto Tsuneyuki,Takagi Ritsuo,Amizuka Norio
Journal of Electron Microscopy 59(3), 227-236, 2010
… The signaling axis comprised by the parathyroid hormone (PTH)-related peptide (PTHrP), the PTH/PTHrP receptor and the fibroblast growth factor receptor 3 (FGFR3) plays a central role in chondrocyte proliferation. … The Indian hedgehog (IHH) gene is normally expressed in early hypertrophic chondrocytes, and its negative feedback loop was shown to regulate PTH/PTHrP receptor signaling. …
NAID 120002834687

The Genome-Wide Expression Profile of Nelumbinis semen on Lipopolysaccharide-Stimulated BV-2 Microglial Cells

Sohn Sung-Hwa,Chung Hwan-Suck,Ko Eunjung,Jeong Hyuk-joon,Kim Sung-Hoon,Jeong Jin-Hyun,Kim Yangseok,Shin Minkyu,Hong Moochang,Bae Hyunsu
Biological and Pharmaceutical Bulletin 32(6), 2009
… The oligonucleotide microarray analysis revealed that mitogen activated protein kinase (MAPK) signaling pathway-related genes such as Fgfr3, Fgf12, Rasal2, Nfkb2, Map2k5, Mapk1, Map3k7, and NFatc2 were down-regulated in LPS activated BV-2 cells by pretreatment with NS. … In addition, significant decreases in Nos1ap gene expression were observed with NS pretreatment. …
NAID 130000117179

FGFR3 K650M変異が同定された severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) 症候群の日本人女性例