excitatory amino acid transporter 5

興奮性アミノ酸トランスポーター5、5型興奮性アミノ酸輸送体

関

EAAT5

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
6. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
7. having the characteristics of an acid; "an acid reaction"
8. a long truck for carrying motor vehicles (同)car transporter
9. a crane for moving material with dispatch as in loading and unloading ships
10. pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
11. the radical -NH2 (同)amino_group

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
3. 自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/04 07:13:51」(JST)

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SLC1A7
Identifiers
Aliases	SLC1A7, AAAT, EAAT5, solute carrier family 1 member 7
External IDs	OMIM: 604471 MGI: 2444087 HomoloGene: 21327 GeneCards: SLC1A7
Gene ontology Molecular function • symporter activity • L-glutamate transmembrane transporter activity • amino acid transmembrane transporter activity • high-affinity glutamate transmembrane transporter activity Cellular component • integral component of membrane • plasma membrane • membrane Biological process • glutamate secretion • ion transport • dicarboxylic acid transport • transmembrane transport • L-glutamate transmembrane transport • amino acid transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6512	242607
Ensembl	ENSG00000162383	ENSMUSG00000008932
UniProt	O00341	Q8JZR4
RefSeq (mRNA)	NM_001287595 NM_001287596 NM_001287597 NM_006671	NM_146255
RefSeq (protein)	NP_001274524 NP_001274525 NP_001274526 NP_006662	NP_666367
Location (UCSC)	Chr 1: 53.09 – 53.14 Mb	Chr 4: 107.97 – 108.01 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412. 
• Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. PMID 15737648. doi:10.1016/j.bbrc.2005.02.035. 
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. PMID 19086053. doi:10.1002/ajmg.b.30902. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 遺伝性運動失調の概要 overview of the hereditary ataxias
• 2. 先天性代謝異常：分類 inborn errors of metabolism classification
• 3. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis
• 4. 先天性代謝異常：代謝性救急疾患 inborn errors of metabolism metabolic emergencies
• 5. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children

English Journal

• Distribution of Na,K-ATPase α subunits in rat vestibular sensory epithelia.

• Schuth O1, McLean WJ, Eatock RA, Pyott SJ.
• Journal of the Association for Research in Otolaryngology : JARO.J Assoc Res Otolaryngol.2014 Oct;15(5):739-54. doi: 10.1007/s10162-014-0479-3. Epub 2014 Aug 5.
• The afferent encoding of vestibular stimuli depends on molecular mechanisms that regulate membrane potential, concentration gradients, and ion and neurotransmitter clearance at both afferent and efferent relays. In many cell types, the Na,K-ATPase (NKA) is essential for establishing hyperpolarized m
• PMID 25091536

• Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.

• Tse DY1, Chung I2, Wu SM3.
• Vision research.Vision Res.2014 Oct;103:49-62. doi: 10.1016/j.visres.2014.07.020. Epub 2014 Aug 22.
• To maintain reliable signal transmission across a synapse, free synaptic neurotransmitters must be removed from the cleft in a timely manner. In the first visual synapse, this critical task is mainly undertaken by glutamate transporters (EAATs). Here we study the differential roles of the EAAT1, EAA
• PMID 25152321

• Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses.

• Tse DY1, Chung I2, Wu SM3.
• Vision research.Vision Res.2014 Oct;103:63-74. doi: 10.1016/j.visres.2014.06.005. Epub 2014 Jun 24.
• A remarkable feature of neuronal glutamate transporters (EAATs) is their dual functions of classical carriers and ligand-gated chloride (Cl(-)) channels. Cl(-) conductance is rapidly activated by glutamate in subtype EAAT5, which mediates light responses in depolarizing bipolar cells (DBC) in retina
• PMID 24972005

Japanese Journal

• Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood–Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina

• Biological and Pharmaceutical Bulletin 38(7), 1087-1091, 2015
• NAID 130005086298

• <i>In Vitro</i> Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 2

• Biological and Pharmaceutical Bulletin 38(6), 901-908, 2015
• NAID 130005072672

• 多様化形質細胞間の神経アミノ酸シグナルの普遍性

• YAKUGAKU ZASSHI 134(8), 879-887, 2014
• NAID 130004677652

Related Pictures

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★リンクテーブル★

リンク元	「EAAT5」「5型興奮性アミノ酸輸送体」「興奮性アミノ酸トランスポーター5」「SLC1A7」
関連記事	「transport」「excitatory」「transporter」

「EAAT5」

　　[★] 興奮性アミノ酸トランスポーター5、5型興奮性アミノ酸輸送体 excitatory amino acid transporter 5

「5型興奮性アミノ酸輸送体」

　　[★]

英

excitatory amino acid transporter 5、EAAT5

関

興奮性アミノ酸トランスポーター5

「興奮性アミノ酸トランスポーター5」

　　[★]

英

excitatory amino acid transporter 5、EAAT5

関

5型興奮性アミノ酸輸送体

「SLC1A7」

　　[★]

• excitatory amino acid transporter 5

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「excitatory」

　　[★]

• 興奮性の、興奮の

関

excitability、excitable、excitation、excite、excitement、exciting、excito、fire

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein