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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/14 16:29:04」(JST)
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| SLC1A7 |
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| Identifiers |
| Aliases |
SLC1A7, AAAT, EAAT5, solute carrier family 1 member 7 |
| External IDs |
OMIM: 604471 MGI: 2444087 HomoloGene: 21327 GeneCards: SLC1A7 |
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| Targeted by Drug |
| DL-TBOA[1] |
| Gene ontology |
| Molecular function |
• symporter activity
• L-glutamate transmembrane transporter activity
• amino acid transmembrane transporter activity
• high-affinity glutamate transmembrane transporter activity
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| Cellular component |
• integral component of membrane
• plasma membrane
• membrane
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| Biological process |
• glutamate secretion
• ion transport
• transport
• dicarboxylic acid transport
• transmembrane transport
• L-glutamate transmembrane transport
• amino acid transmembrane transport
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| Sources:Amigo / QuickGO |
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| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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NM_001287595
NM_001287596
NM_001287597
NM_006671
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| RefSeq (protein) |
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NP_001274524
NP_001274525
NP_001274526
NP_006662
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| Location (UCSC) |
Chr 1: 53.09 – 53.14 Mb |
Chr 4: 107.97 – 108.01 Mb |
| PubMed search |
[2] |
[3] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[4][5]
EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[5]
References
- ^ "Drugs that physically interact with Solute carrier family 1 member 7 view/edit references on wikidata".
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ "Entrez Gene: solute carrier family 1 (glutamate transporter)".
- ^ a b Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. doi:10.1073/pnas.94.8.4155. PMC 20584. PMID 9108121.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412.
- Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
- Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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| Symporter, Cotransporter |
- Na+/K+,Cl−
- Na+/Pi3
- Na+/Cl−
- Na+/glucose
- Na+/I−
- Cl−/K+
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| Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
- Cl−-formate
- Cl−-oxalate
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see also solute carrier disorders
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English Journal
- Distribution of Na,K-ATPase α subunits in rat vestibular sensory epithelia.
- Schuth O1, McLean WJ, Eatock RA, Pyott SJ.
- Journal of the Association for Research in Otolaryngology : JARO.J Assoc Res Otolaryngol.2014 Oct;15(5):739-54. doi: 10.1007/s10162-014-0479-3. Epub 2014 Aug 5.
- The afferent encoding of vestibular stimuli depends on molecular mechanisms that regulate membrane potential, concentration gradients, and ion and neurotransmitter clearance at both afferent and efferent relays. In many cell types, the Na,K-ATPase (NKA) is essential for establishing hyperpolarized m
- PMID 25091536
- Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
- Tse DY1, Chung I2, Wu SM3.
- Vision research.Vision Res.2014 Oct;103:49-62. doi: 10.1016/j.visres.2014.07.020. Epub 2014 Aug 22.
- To maintain reliable signal transmission across a synapse, free synaptic neurotransmitters must be removed from the cleft in a timely manner. In the first visual synapse, this critical task is mainly undertaken by glutamate transporters (EAATs). Here we study the differential roles of the EAAT1, EAA
- PMID 25152321
- Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses.
- Tse DY1, Chung I2, Wu SM3.
- Vision research.Vision Res.2014 Oct;103:63-74. doi: 10.1016/j.visres.2014.06.005. Epub 2014 Jun 24.
- A remarkable feature of neuronal glutamate transporters (EAATs) is their dual functions of classical carriers and ligand-gated chloride (Cl(-)) channels. Cl(-) conductance is rapidly activated by glutamate in subtype EAAT5, which mediates light responses in depolarizing bipolar cells (DBC) in retina
- PMID 24972005
Related Links
- Complete information for SLC1A7 gene (Protein Coding), Solute Carrier Family 1 (Glutamate Transporter), Member 7, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... A ...
- MBLのおすすめAnti-SLC1A7 (EAAT5) (Human) pAb（Polyclonal, Polyclonal）。 使用法：Western Blotting, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Other 交差性：Human ... データ Western Blotting Flow ...
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