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the most powerful female hormone that occurs naturally; synthesized and used to treat estrogen deficiency and breast cancer (同)oestradiol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/04 06:36:54」(JST)

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Estradiol dipropionate (BAN, JAN; brand names Agofollin, Diovocyclin, Progynon-DP, others) is a synthetic ester, specifically the 3,17-dipropanoyl ester, of the natural estrogen, estradiol.^[1]^[2] Alongside estradiol benzoate, estradiol dipropionate was one of the first estradiol esters to be developed, having been patented in 1937,^[3] and has been marketed since at least the 1940s.^[4]

References

^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 406. ISBN 978-3-88763-075-1. Retrieved 20 May 2012.
^ States2233025 United States 2233025, Karl Miescher, Riehen, & Caesar Scholz, "Estradiol-17-monoesters", published 1941-02-25, assigned to Ciba Pharmaceutical Products, Inc.
^ Reece RP, Leathem, JH (June 1945). "Growth of mammary glands of hypophysectomized rats following estrogen and lactogen administration". Experimental Biology and Medicine 59 (2): 122–124. doi:10.3181/00379727-59-15001.

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1. エストロゲン・プロゲスチン避妊剤の使用に関する概要 overview of the use of estrogen progestin contraceptives
2. 閉経期のホルモン療法で用いる製剤 preparations for menopausal hormone therapy
3. 緊急避妊剤 emergency contraception
4. 経皮吸収避妊パッチ transdermal contraceptive patch
5. 月経抑制のためのホルモン避妊法 hormonal contraception for suppression of menstruation

English Journal

The effects of sex steroids on thyroid C cells and trabecular bone structure in the rat model of male osteoporosis.

Filipović B, Sošić-Jurjević B, Ajdžanović V, Pantelić J, Nestorović N, Milošević V, Sekulić M.SourceInstitute for Biological Research, University of Belgrade, Belgrade, Serbia. brankof@ibiss.bg.ac.rs
Journal of anatomy.J Anat.2013 Mar;222(3):313-20. doi: 10.1111/joa.12013. Epub 2012 Nov 21.
Androgen deficiency is one of the major factors leading to the development of osteoporosis in men. Since calcitonin (CT) is a potent antiresorptive agent, in the present study we investigated the effects of androgen deficiency and subsequent testosterone and estradiol treatment on CT-producing thyro
PMID 23171170

Reproductive hormone profiles in sows on estrus synchronization using estradiol dipropionate and prostaglandin F(2α)-analogue and the reproductive performance in female pigs on commercial farms.

Noguchi M, Kashiwai S, Itoh S, Okumura H, Kure K, Suzuki C, Yoshioka K.SourcePathology and Pathophysiology Research Division, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2013;75(3):343-8. Epub 2012 Nov 5.
Changes in ovarian structures and hormonal profiles in estradiol dipropionate (EDP)-induced pseudopregnant sows following PGF2α-analogue (PGF2α-A) administration and practicality of the estrus synchronization protocol using EDP and PGF2α-A on estrus expression and reproductive performance in comm
PMID 23131781

The effect of estrogen administration during early pregnancy upon the survival of single implanted pig embryos.

Kawarasaki T, Enya S, Otsu Y.SourceSwine and Poultry Research Center, Shizuoka Prefectural Research Institute of Animal Industry, Kikugawa, Shizuoka, 439-0037, Japan. kawarasaki@tokai-u.jp
Journal of animal science.J Anim Sci.2012 Dec;90(13):4781-7. doi: 10.2527/jas.2012-5178. Epub 2012 Jul 24.
In the present study, we investigated the influence of exogenous estrogen on embryo survival after transfer into prepubertal gilts in which estrus had been induced. In the first experiment, estrus was induced in prepubertal gilts by the administration of 1,000 IU of eCG and 750 IU of hCG every 72 h.
PMID 22829621

Japanese Journal

Reproductive Hormone Profiles in Sows on Estrus Synchronization Using Estradiol Dipropionate and Prostaglandin F2α-Analogue and the Reproductive Performance in Female Pigs on Commercial Farms

NOGUCHI Michiko,KASHIWAI Shinsuke,ITOH Seigo,OKUMURA Hanako,KURE Katsumasa,SUZUKI Chie,YOSHIOKA Koji
Journal of Veterinary Medical Science, 2012
… Changes in ovarian structures and hormonal profiles in estradiol dipropionate (EDP)-induced pseudopregnant sows following PGF2α-analogue (PGF2α-A) administration and practicality of the estrus synchronization protocol using EDP and PGF2α-A on estrus expression and reproductive performance in commercial conditions were investigated. …
NAID 130001879627

Estrus Synchronization with Pseudopregant Gilts Induced by a Single Treatment of Estradiol Dipropionate

Noguchi Michiko,Yoshioka Koji,Suzuki Chie [他],ARAI Sachiko,ITOH Seigo,WADA Yasunori
The Journal of reproduction and development 56(4), 421-427, 2010-08-01
… The aims of this study were to determine whether a single treatment of estradiol dipropionate (EDP) could induce pseudopregnancy in gilts and to determine the effectiveness of PGF2α treatment on estrus synchronization in EDP-induced pseudopregnant gilts. … The plasma estradiol-17β level was significantly higher in the EDP-treated gilts than in the control gilts until Day 29. …
NAID 10026621686

Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta

Yamaguchi Kiyoshi,Honda Hideo,Wakisaka Chiaki [他],TOHEI Atsushi,KOGO Hiroshi
The Japanese journal of pharmacology 87(1), 67-73, 2001-09-01
… Estrogen replacement (17β-estradiol dipropionate, 300 μg/kg per week, for 1 month) completely restored the impaired ACh- and ISO-induced vasodilation caused by ovariectomy. …
NAID 130000078341

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★リンクテーブル★

リンク元	「エストラジオール」
関連記事	「dipropionate」「estradiol」

「エストラジオール」

Estradiol dipropionate
Systematic (IUPAC) name
	(17β)-estra-1,3,5(10)-triene-3,17-diyl dipropanoate
Clinical data
Legal status	℞ (Prescription only);
Routes of; administration	IM
Identifiers
CAS Registry Number	113-38-2
ATC code	None
PubChem	CID 8225
ChemSpider	7932
UNII	NIG5418BXB
Synonyms	17β-Estradiol-3,17-dipropionate
Chemical data
Formula	C24H32O4
Molecular mass	384.509 g/mol
	SMILES O=C(Oc1cc3c(cc1)[C@H]2CC[C@@]4([C@@H](OC(=O)CC)CC[C@H]4[C@@H]2CC3)C)CC;
	InChI InChI=1S/C24H32O4/c1-4-22(25)27-16-7-9-17-15(14-16)6-8-19-18(17)12-13-24(3)20(19)10-11-21(24)28-23(26)5-2/h7,9,14,18-21H,4-6,8,10-13H2,1-3H3/t18-,19-,20+,21+,24+/m1/s1; Key:JQIYNMYZKRGDFK-RUFWAXPRSA-N ;