eosinophil major basic protein

好酸球主要塩基性タンパク質

WordNet

1. of the field of academic study in which one concentrates or specializes; "his major field was mathematics"
2. a commissioned military officer in the United States Army or Air Force or Marines; below lieutenant colonel and above captain
3. a university student who is studying a particular field as the principal subject; "she is a linguistics major"
4. the principal field of study of a student at a university; "her major is linguistics"
5. greater in number or size or amount; "a major portion (a majority) of the population"; "Ursa Major"; "a major portion of the winnings"
6. greater in scope or effect; "a major contribution"; "a major improvement"; "a major break with tradition"; "a major misunderstanding"
7. have as ones principal field of study; "She is majoring in linguistics"
8. of a scale or mode; "major scales"; "the key of D major"
9. of full legal age
10. of greater importance or stature or rank; "a major artist"; "a major role"; "major highways"
11. of greater seriousness or danger; "a major earthquake"; "a major hurricane"; "a major illness"
12. of the elder of two boys with the same family name; "Jones major"
13. pertaining to or constituting a base or basis; "a basic fact"; "the basic ingredients"; "basic changes in public opinion occur because of changes in priorities"
14. (usually plural) a necessary commodity for which demand is constant (同)staple
15. reduced to the simplest and most significant form possible without loss of generality; "a basic story line"; "a canonical syllable pattern" (同)canonic, canonical
16. serving as a base or starting point; "a basic course in Russian"; "basic training for raw recruits"; "a set of basic tools"; "an introductory art course" (同)introductory
17. of or denoting or of the nature of or containing a base
18. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
19. a popular programming language that is relatively easy to learn; an acronym for beginners all-purpose symbolic instruction code; no longer in general use
20. a statement of fundamental facts or principles (同)rudiments

PrepTutorEJDIC

1. 『大きい』(『多い』)『ほうの』,いっそう重要な / (音階が)長調の,長音階の / 《英》《昔の学校で同姓または兄弟生徒を区別するために姓の後につけて》年長の,兄の / 《しばしばM-》陸軍(空軍)少佐 / 《米》専攻科目;専攻学生 / 《the majors》《米》=major leagues / (科目を)専攻する《+『in』+『名』》
2. 『基礎の』,基本的な(fundamental) / 塩基性(アルカリ性)の
3. 蛋白(たんばく)質
4. 基本,基礎

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/17 20:08:50」(JST)

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Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1H8U, 2BRS
Identifiers
Symbols	PRG2 ; BMPG; MBP; MBP1
External IDs	OMIM: 605601 MGI: 103294 HomoloGene: 2044 GeneCards: PRG2 Gene
Gene Ontology Molecular function • heparin binding • carbohydrate binding Cellular component • extracellular region • transport vesicle Biological process • immune response • defense response to bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5553	19074
Ensembl	ENSG00000186652	ENSMUSG00000027073
UniProt	P13727	Q61878
RefSeq (mRNA)	NM_001243245	NM_008920
RefSeq (protein)	NP_001230174	NP_032946
Location (UCSC)	Chr 11: 57.15 – 57.16 Mb	Chr 2: 84.98 – 84.98 Mb
PubMed search	[1]	[2]

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene.

Function

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.

PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.

Structure

Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins (those that bind various carbohydrates in the presence of calcium), MBP does not bind either calcium or any of the other carbohydrates that this family recognize.

Instead, MBP recognises heparan sulfate proteoglycans. Two crystallographic structures of MBP have been determined.

Interactions

Major basic protein has been shown to interact with Pregnancy-associated plasma protein A.

See also

arylsulfatase

References

External links

• Eosinophil Major Basic Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Vanhaesebroeck B, Alessi DR (2000). "The PI3K-PDK1 connection: more than just a road to PKB". Biochem. J. 346 (3): 561–76. doi:10.1042/0264-6021:3460561. PMC 1220886. PMID 10698680. 
• Yoshimatsu K, Ohya Y, Shikata Y et al. (1992). "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins". Mol. Immunol. 29 (4): 537–546. doi:10.1016/0161-5890(92)90012-M. PMID 1565101. 
• Barker RL, Loegering DA, Arakawa KC et al. (1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene 86 (2): 285–289. doi:10.1016/0378-1119(90)90292-Y. PMID 2323577. 
• Gabay JE, Scott RW, Campanelli D et al. (1989). "Antibiotic proteins of human polymorphonuclear leukocytes". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5610–5614. doi:10.1073/pnas.86.14.5610. PMC 297672. PMID 2501794. 
• Wasmoen TL, McKean DJ, Benirschke K et al. (1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6): 2051–2063. doi:10.1084/jem.170.6.2051. PMC 2189540. PMID 2584934. 
• Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp. Med. 168 (4): 1493–1498. doi:10.1084/jem.168.4.1493. PMC 2189086. PMID 3171483. 
• McGrogan M, Simonsen C, Scott R et al. (1989). "Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein". J. Exp. Med. 168 (6): 2295–2308. doi:10.1084/jem.168.6.2295. PMC 2189145. PMID 3199069. 
• Wasmoen TL, Bell MP, Loegering DA et al. (1988). "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein". J. Biol. Chem. 263 (25): 12559–63. PMID 3410852. 
• Weller PF, Ackerman SJ, Smith JA (1988). "Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. Leukoc. Biol. 43 (1): 1–4. PMID 3422083. 
• Kristensen T, Oxvig C, Sand O et al. (1994). "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA". Biochemistry 33 (6): 1592–1598. doi:10.1021/bi00172a040. PMID 7508748. 
• Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L (1994). "Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum". Biochem. Mol. Biol. Int. 33 (2): 329–36. PMID 7524900. 
• Bonno M, Oxvig C, Kephart GM et al. (1994). "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta". Lab. Invest. 71 (4): 560–6. PMID 7526035. 
• Li MS, Sun L, Satoh T et al. (1995). "Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters". Biochem. J. 305 (3): 921–7. PMC 1136346. PMID 7531438. 
• Oxvig C, Haaning J, Kristensen L et al. (1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma". J. Biol. Chem. 270 (23): 13645–13651. doi:10.1074/jbc.270.23.13645. PMID 7539791. 
• Oxvig C, Sand O, Kristensen T et al. (1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17): 12243–6. PMID 7685339. 
• Levi-Schaffer F, Lacy P, Severs NJ et al. (1995). "Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils". Blood 85 (9): 2579–86. PMID 7727786. 
• Oxvig C, Gleich GJ, Sottrup-Jensen L (1994). "Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein". FEBS Lett. 341 (2–3): 213–217. doi:10.1016/0014-5793(94)80459-1. PMID 8137941. 
• Shikata Y, Hayashi Y, Yoshimatsu K et al. (1993). "Pro-major basic protein has three types of sugar chains at the pro-portion". Biochim. Biophys. Acta 1163 (3): 243–9. doi:10.1016/0167-4838(93)90158-N. PMID 8507662. 
• Nittoh T, Watanabe M, Okayama H et al. (1996). "Cloning of cDNA for rat eosinophil major basic protein". Biochim. Biophys. Acta 1264 (3): 261–4. PMID 8547309. 
• Delcommenne M, Tan C, Gray V et al. (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11211–11216. doi:10.1073/pnas.95.19.11211. PMC 21621. PMID 9736715. 

UpToDate Contents

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• 1. 喘息の病因 pathogenesis of asthma
• 2. 好酸球増加症候群の臨床症状、病態生理、および診断 clinical manifestations pathophysiology and diagnosis of the hypereosinophilic syndromes
• 3. 好酸球性食道炎の病因、臨床症状、および診断 pathogenesis clinical manifestations and diagnosis of eosinophilic esophagitis
• 4. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
• 5. 好酸球性胃腸炎 eosinophilic gastroenteritis

English Journal

• Formation of high-molecular weight angiotensinogen during pregnancy is a result of competing redox reactions with proform of eosinophil major basic protein.

• Kløverpris S, Skov LL, Glerup S, Pihl K, Christiansen M, Oxvig C.AbstractThe plasma concentration of placentally derived proform of eosinophil major basic protein (proMBP) increases in pregnancy, and three different complexes containing proMBP have been isolated from pregnancy plasma and serum: A 2:2 complex with the metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A), a 2:2 complex with angiotensinogen (AGT), and a 2:2:2 complex with AGT and complement C3dg. We show that during human pregnancy, all of circulating proMBP exists in covalent complexes, bound to either PAPP-A or AGT. We also show that the proMBP/AGT complex constitutes the major fraction of circulating high-molecular weight (HMW) AGT in late pregnancy, and that this complex is able to further associate with complement C3 derivatives post-sampling. Clearance experiments in mice suggest that complement C3-based complexes are removed faster from the circulation compared to monomeric AGT and the proMBP/AGT complex. Furthermore, we have used recombinant proteins to analyze formation of the proMBP/PAPP-A and the proMBP/AGT complexes, and we demonstrate that they are competing reactions, depending on the same cysteine residue of proMBP, but differentially on the redox potential, potentially important for the relative amounts of the complexes in vivo. These findings may be important physiologically, since the biochemical properties of the proteins change as a consequence of complex formation.
• The Biochemical journal.Biochem J.2012 Oct 4. [Epub ahead of print]
• The plasma concentration of placentally derived proform of eosinophil major basic protein (proMBP) increases in pregnancy, and three different complexes containing proMBP have been isolated from pregnancy plasma and serum: A 2:2 complex with the metalloproteinase, pregnancy-associated plasma protein
• PMID 23033876

• Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis.

• Dellon ES, Chen X, Miller CR, Woosley JT, Shaheen NJ.Source1] Center for Esophageal Diseases and Swallowing, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA [2] Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
• The American journal of gastroenterology.Am J Gastroenterol.2012 Oct;107(10):1503-11. doi: 10.1038/ajg.2012.202. Epub 2012 Jul 10.
• OBJECTIVES: Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap. We aimed to determine whether staining for tissue biomarkers would differentiate EoE from GERD, suggesting utility for diagnosis of EoE.METHODS: In this case-control study, EoE patients defined
• PMID 22777338

Japanese Journal

• Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein

• Hara Tomoya,Yamaguchi Koji,Iwase Takashi,Kadota Muneyuki,Bando Mika,Ogasawara Kozue,Bando Sachiko,Ise Takayuki,Niki Toshiyuki,Ueda Yuka,Tomita Noriko,Taketani Yoshio,Yamada Hirotsugu,Soeki Takeshi,Wakatsuki Tetsuzo,Sata Masataka
• International Heart Journal 54(1), 51-53, 2013
• … Laboratory data showed leukocytosis, hypereosinophilia (10,450/<I>μ</I>L), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> … Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. …
• NAID 130003364440

• Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation

• LIU Qingquan,DONG Fan
• International journal of hematology 95(6), 640-647, 2012-06-01
• NAID 10030793557

• Production and Regulation of Eotaxin-2/CCL24 in a Differentiated Human Leukemic Cell Line, HT93(Biochemistry)

• Yoshida Naomi,Aizu-Yokota Eriko,Sonoda Yoshiko [他],MORIWAKI Yasuhiro,KISHI Kenji,KASAHARA Tadashi
• Biological & pharmaceutical bulletin 30(10), 1826-1832, 2007-10-01
• … When a human leukemic cell line, HT93 was incubated with all-trans retinoic acid (ATRA), IL-5, or both, this cell line was differentiated into eosinophic lineage, in that an eosinophilic specific granule proteins, major basic protein (MBP) and eosinophil peroxidase (EPO) appeared. …
• NAID 110006436358

Related Links

• Major basic protein - Wikipedia, the free encyclopedia

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) ... The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar ...

• Eosinophil major basic protein: first identified natural heparanase ...

J Allergy Clin Immunol. 2004 Apr;113(4):703-9. Eosinophil major basic protein: first identified natural heparanase-inhibiting protein. Temkin V, Aingorn H, Puxeddu I, Goldshmidt O, Zcharia E, Gleich GJ, Vlodavsky I, Levi-Schaffer F. Department ...

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リンク元	「好酸球主要塩基性タンパク質」
関連記事	「basic」「major」「basic protein」

「好酸球主要塩基性タンパク質」

　　[★]

英

eosinophil major basic protein

「basic」

　　[★]

• adj.

• 基礎の、基礎的な、基本の、基本的な、(化学)塩基の、塩基性の、ベーシックな

関

basal、base、bases、basically、basicity、basis、cardinal、element、elemental、elementary、essential、essentially、fundamental、fundamentally、fundamentals

　 　 　 　 　 　

「major」

　　[★]

• adj.

• 主要な、主な、専攻する、メジャーな

関

cardinal、chief、chiefly、foremost、main、mainly、master、mostly、predominant、predominantly、primarily、primary、principal、principally

　 　 　 　 　 　 　 　 　 　 　 　 　

「basic protein」

　　[★]

• 塩基性タンパク質、塩基性蛋白質、塩基性蛋白