WordNet

extremely; "he was enormously popular" (同)tremendously, hugely, staggeringly
precisely so; "on the very next page"; "he expected the very opposite"
used as intensifiers; `real is sometimes used informally for `really; `rattling is informal; "she was very gifted"; "he played very well"; "a really enjoyable evening"; "Im real sorry about it"; "a rattling good yarn" (同)really, real, rattling
precisely as stated; "the very center of town"
unusually great in size or amount or degree or especially extent or scope; "huge government spending"; "huge country estates"; "huge popular demand for higher education"; "a huge wave"; "the Los Angeles aqueduct winds like an immense snake along the base of the mountains"; "immense numbers of birds"; "at vast (or immense) expense"; "the vast reaches of outer space"; "the vast accumulation of knowledge...which we call civilization"- W.R.Inge (同)immense, vast, Brobdingnagian
to an extreme degree; "extremely cold"; "extremely unpleasant" (同)exceedingly, super, passing
to an extraordinary extent or degree; "he improved greatly"
extraordinarily large in size or extent or amount or power or degree; "an enormous boulder"; "enormous expenses"; "tremendous sweeping plains"; "a tremendous fact in human experience; that a whole civilization should be dependent on technology"- Walter Lippman; "a plane took off with a tremendous noise" (同)tremendous

PrepTutorEJDIC

《副詞・形容詞・分詞形容詞を強めて》『非常に』,とても,たいへん,きわめて / 《否定語と共に用いて》『あまり』,さほど,たいして(…でない) / 《same, opposite, [one's]ownなどの前で》『真に,まったく』,ほんとうに / 《古》まったくの,本物の,真の / 《the(this,that,one's)~》『まさにその』,ちょうどその / 《the(one's)~》ただ…だけで(mere);(…)でさえ,までも(even)
(かさ・量・程度などが)『巨大な』,ばく大な;《話》たいへんな
『極端に』,非常に過度に
悲常に,大いに,とても
『大いに,非常に』
『巨大な』,ばく大な

UpToDate Contents

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1. 先天性腎盂尿管移行部閉塞 congenital ureteropelvic junction obstruction
2. HIVヌクレオシド系逆転写酵素阻害剤のミトコンドリア毒性 mitochondrial toxicity of hiv nucleoside reverse transcriptase inhibitors
3. 自己免疫性溶血性貧血の病因：寒冷凝集素症 pathogenesis of autoimmune hemolytic anemia cold agglutinin disease
4. 肺移植：レシピエント選定のための一般的ガイドライン lung transplantation general guidelines for recipient selection
5. 中長期的な機械循環補助 intermediate and long term mechanical circulatory support

English Journal

Nanotoxicology using the sea anemone Nematostella vectensis: from developmental toxicity to genotoxicology.

Ambrosone A1, Marchesano V, Mazzarella V, Tortiglione C.Author information 1Istituto di Cibernetica "E.Caianiello", Consiglio Nazionale delle Ricerche , Pozzuoli , Italy.AbstractConcomitant with the fast-growing advances in the synthesis and engineering of colloidal nanocrystals, an urgent evaluation of their toxicity on human beings and environment is strongly encouraged by public health organisations. Despite the in vitro approaches employed for toxicological screening of hazardous compounds, the use of simple and cost-effective living organisms may enormously contribute to solve unanswered questions related to embryotoxic and teratogenic effects of nanomaterials. Here, the sea anemone Nematostella vectensis (Cnidaria, Anthozoa) is presented as a novel model organism to profile bio/non-bio interactions and to show a comprehensive toxicological analysis performed on embryos, larvae and adults treated with fluorescent cadmium-based nanocrystals. Spanning from in vivo biodistribution to molecular investigations, different behaviours and effects depending on the composition and surface coatings are showed. Rod-shaped cadmium selenide/cadmium sulfide (CdSe/CdS) nanocrystals resulted in excellent imaging probes to track N. vectensis development with negligible adverse effects, while spherical CdTe nanocrystals severely impaired embryogenesis, resulting in aberrant phenotypes and deregulation of developmental genes, which raise severe worries for a safe use of this type of nanoparticles for human purposes and environmental contamination.
Nanotoxicology.Nanotoxicology.2014 Aug;8(5):508-20. doi: 10.3109/17435390.2013.802386. Epub 2013 Jun 3.
Concomitant with the fast-growing advances in the synthesis and engineering of colloidal nanocrystals, an urgent evaluation of their toxicity on human beings and environment is strongly encouraged by public health organisations. Despite the in vitro approaches employed for toxicological screening of
PMID 23641943

Renal aquaporins and water balance disorders.

Kortenoeven ML1, Fenton RA2.Author information 1Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Interactions of Proteins in Epithelial Transport (InterPrET), Aarhus University, Aarhus, Denmark. Electronic address: mkor@ana.au.dk.2Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Interactions of Proteins in Epithelial Transport (InterPrET), Aarhus University, Aarhus, Denmark. Electronic address: rofe@ana.au.dk.AbstractBACKGROUND: Aquaporins (AQPs) are a family of proteins that can act as water channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body water homeostasis. Eight AQPs are expressed in the kidney of which five have been shown to play a role in body water balance; AQP1, AQP2, AQP3, AQP4 and AQP7. AQP2 in particular is regulated by vasopressin.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1840(5):1533-49. doi: 10.1016/j.bbagen.2013.12.002. Epub 2013 Dec 15.
BACKGROUND: Aquaporins (AQPs) are a family of proteins that can act as water channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body water homeostasis. Eight AQPs are expressed in the kidney of which five have been shown to play a role in body water balance; AQP1, AQP2
PMID 24342488

Socio-demographic and fertility-related characteristics and motivations of oocyte donors in eleven European countries.

Pennings G1, de Mouzon J, Shenfield F, Ferraretti AP, Mardesic T, Ruiz A, Goossens V.Author information 1Bioethics Institute Ghent (BIG), Ghent University, Blandijnberg 2, B-9000 Ghent, Belgium.AbstractSTUDY QUESTION: Do the socio-demographic and fertility-related characteristics and motivations of oocyte donors differ in European countries?
Human reproduction (Oxford, England).Hum Reprod.2014 May;29(5):1076-89. doi: 10.1093/humrep/deu048. Epub 2014 Mar 13.
STUDY QUESTION: Do the socio-demographic and fertility-related characteristics and motivations of oocyte donors differ in European countries SUMMARY ANSWER: The socio-demographic and fertility-related characteristics and motivations of oocyte donors differ considerably across countries.WHAT IS KNOWN
PMID 24626802

Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera.

Votavova P1, Tomala J1, Kovar M2.Author information 1Laboratory of Tumor Immunology, Institute of Microbiology of Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.2Laboratory of Tumor Immunology, Institute of Microbiology of Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic. Electronic address: makovar@biomed.cas.cz.AbstractIL-2 and IL-15 are structurally relative cytokines that share two receptor subunits, CD132 (γc chain) and CD122 (β chain). However, the expression pattern and physiological role of IL-2 and IL-15 private receptor α chains CD25 and IL-15Rα, respectively, are strikingly different. CD25, together with CD122 and CD132, forms a trimeric high affinity IL-2 receptor that is expressed and functions on cells acquiring an IL-2 signal. Conversely, IL-15Rα is expressed and binds IL-15 with high affinity per se already in the endoplasmic reticulum of the IL-15 producing cells and it presents IL-15 to cells expressing CD122/CD132 dimeric receptor in trans. Thus, while IL-2 is secreted almost exclusively by activated T cells and acts as a free molecule, IL-15 is expressed mostly by myeloid cells and works as a cell surface-associated cytokine. Interestingly, the in vivo biological activity of IL-2 can be dramatically increased through complexing with certain anti-IL-2 mAbs; such IL-2/anti-IL-2 mAbs immunocomplexes selectively stimulate the proliferation of a distinct population of immune cells, depending on the clone of the anti-IL-2 mAb used. IL-2/S4B6 mAb immunocomplexes are highly stimulatory for CD122high populations (memory CD8+ T and NK cells) and intermediately also for CD25high populations (Treg and activated T cells), while IL-2/JES6-1 mAb immunocomplexes enormously expand only CD25high cells. Although IL-2 immunocomplexes are much more potent than IL-2 in vivo, they show comparable to slightly lower activity in vitro. The in vivo biological activity of IL-15 can be dramatically increased through complexing with recombinant IL-15Rα-Fc chimera; however, IL-15/IL-15Rα-Fc complexes are significantly more potent than IL-15 both in vivo and in vitro. In this review we summarize and discuss the features and biological relevance of IL-2/anti-IL-2 mAbs and IL-15/IL-15Rα-Fc complexes, and try to foreshadow their potential in immunological research and immunotherapy.
Immunology letters.Immunol Lett.2014 May - June;159(1-2):1-10. doi: 10.1016/j.imlet.2014.01.017. Epub 2014 Feb 7.
IL-2 and IL-15 are structurally relative cytokines that share two receptor subunits, CD132 (γc chain) and CD122 (β chain). However, the expression pattern and physiological role of IL-2 and IL-15 private receptor α chains CD25 and IL-15Rα, respectively, are strikingly different. CD25, together w
PMID 24512738

Japanese Journal

Beyond Measuring the Voice of the People: The Evolving Role of Political Polling in Indonesia's Local Leader Elections

Agus Trihartono
Southeast Asian Studies 3(1), 151–182, 2014-04-24
… Since 2005, political polling and the application of polls-based candidacy have been enormously influential and, in fact, have become vital for local leader elections(Pilkada), particularly in Indonesia's districts and municipalities. …
NAID 110009759625

<Articles>Beyond Measuring the Voice of the People: The Evolving Role of Political Polling in Indonesia's Local Leader Elections

Trihartono Agus
Southeast Asian Studies 3(1), 151-182, 2014-04
… Since 2005, political polling and the application of polls-based candidacy have been enormously influential and, in fact, have become vital for local leader elections (Pilkada), particularly in Indonesia's districts and municipalities. …
NAID 120005434962

TPMのルーツを探る : TPMの温故知新(<特集>『品質管理事始め(ルーツを探る)』第3報)

久保田洋志
品質 44(1), 19-24, 2014-01-15
… This article shows key activities and roles of pioneers and organizations such as JIPM and the TPM Excellent Award Committee which have contributed enormously to the evolution and/or development processes of the TPM, and then clarifies core concepts and backgrounds for basic ways of thinking such as definitions on TPM, organizational deployment such as step approach and overlap small group activity, and methodology and techniques such as PM analysis and approach to minor stoppage loss. …
NAID 110009688734

アナログレコードのオークション価格 : 価格形成要因としての神話と象徴

横川潤
文教大学国際学部紀要 24(2), 65-79, 2014-01
… It is the same as in Classical music and record with myth and symbol would be bought at enormously high price. …
NAID 120005378802

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★リンクテーブル★

リンク元	「exceedingly」「extraordinarily」「very」「extremely」「immensely」
関連記事	「enormous」

「exceedingly」

　　[★]

adv.

きわめて、非常に、すこぶる

Diarrhea and constipation are exceedingly common and together exact an enormous toll in terms of mortality, morbidity, social inconvenience, loss of work productivity, and consumption of medical resources.(HIM.245)