WordNet
- to a lower intensity; "he slowly phased down the light until the stage was completely black"
- soft fine feathers (同)down feather
- (American football) a complete play to advance the football; "you have four downs to gain ten yards"
- fine soft dense hair (as the fine short hair of cattle or deer or the wool of sheep or the undercoat of certain dogs) (同)pile
- (usually plural) a rolling treeless highland with little soil
- understood perfectly; "had his algebra problems down" (同)down pat, mastered
- extending or moving from a higher to a lower place; "the down staircase"; "the downward course of the stream" (同)downward
- spatially or metaphorically from a higher to a lower level or position; "dont fall down"; "rode the lift up and skied down"; "prices plunged downward" (同)downwards, downward, downwardly
- cause to come or go down; "The policeman downed the heavily armed suspect"; "The mugger knocked down the old lady after she refused to hand over her wallet" (同)knock down, cut_down, push down, pull down
- shoot at and force to come down; "the enemy landed several of our aircraft" (同)shoot down, land
- away from a more central or a more northerly place; "was sent down to work at the regional office"; "worked down on the farm"; "came down for the wedding"; "flew down to Florida"
- becoming progressively lower; "the down trend in the real estate market"
- being or moving lower in position or less in some value; "lay face down"; "the moon is down"; "our team is down by a run"; "down by a pawn"; "the stock market is down today"
- being put out by a strikeout; "two down in the bottom of the ninth"
- bring down or defeat (an opponent)
- from an earlier time; "the story was passed down from father to son"
- in an inactive or inoperative state; "the factory went down during the strike"; "the computer went down again"
- not functioning (temporarily or permanently); "we cant work because the computer is down"
- paid in cash at time of purchase; "put ten dollars down on the necklace"
- shut; "the shades were down"
- travel or traverse (a distance); "This car does 150 miles per hour"; "We did 6 miles on our hike every day"
- the syllable naming the first (tonic) note of any major scale in solmization (同)doh, ut
- proceed or get along; "How is she doing in her new job?"; "How are you making out in graduate school?"; "Hes come a long way" (同)fare, make_out, come, get along
- create or design, often in a certain way; "Do my room in blue"; "I did this piece in wood to express my love for the forest" (同)make
- carry on or function; "We could do with a little more help around here" (同)manage
- get (something) done; "I did my job" (同)perform
- prescribed by or according to regulation; "regulation army equipment"
- (embryology) the ability of an early embryo to continue normal development after its structure has been somehow damaged or altered
- the state of being controlled or governed
- the act of bringing to uniformity; making regular (同)regularization, regularisation
- the act of controlling or directing according to rule; "fiscal regulations are in the hands of politicians" (同)regulating
- an authoritative rule (同)ordinance
- English physician who first described Downs syndrome (1828-1896) (同)John L. H. Down
PrepTutorEJDIC
- (高い所から)『下へ』,降りて,地面へ / (地理・地図上)南へ,下町へ;(風・流れなどが)『下(しも)手へ』;《英》(都会・大学から)地方へ,離れて / (価格・品質・温度などが)『下がって』,(数量・スピードなどが)少なく,減じて,(濃度が)薄く / (健康・風の勢いなどが)『衰えて』,気分が沈んで / (時代などが)下がって,…に至るまで / (身分・地位が)下がって / (紙面に)書き留めて,記録して / (頭金を)現金で,即金で / 最後まで,徹底的に / しっかりと,動けないように / (高い所から)…『を下がって』;…『に沿って』;…の向こうに / …の下流に / …以来 / 《名詞の前にのみ用いて》『下りの』,下への / 《名詞の前にのみ用いて》(列車・バスなどが)下りの / 《補語にのみ用いて》下に,下がって / 《補語にのみ用いて》弱まった,おさまった;落胆した,元気のない / 《補語にのみ用いて》(勝負で)負けて,すって / 《補語にのみ用いて》《おもに米話》(野球で)アウト / …‘を'打倒する,負かす,撃ち落とす / …‘を'飲み干す,飲み込む / 下り,下降 / 《複数形で》不運,逆境
- (鳥の)綿毛,うぶ毛,下羽 / (植物・果実の表面の)柔らかい毛
- なだらかな草原地,丘陵地帯(特にイングランド南部の小高い白亜質の草原地the Downsを言う)
- 《疑問文・否定文を作る》 / 《否定命令文を作る》 / 《助動詞とbe動詞のどちらも含まない文に用いて付加疑問を作る》 / 《強意語として》 / 《文》《助動詞とbe動詞のどちらも含まない文に用いて倒置文を作る》 / 《あいづちを打つ場合に》 / 《先行する動詞またはそれを含む述部の代用》 / 《so,nor,neitherで始まる簡略文で》 / …‘を'『する』,行う,果たす / 《通例have done,時にbe doneの形で》…‘を'『終える』,済ませる / …‘を'作る,作り出す / …‘を'『処理する』,整える,片付ける / 〈学課〉‘を'『勉強する』,専攻する / 〈利益・害など〉‘を'与える,もたらす / 〈人〉‘に'『役立つ』,用が足りる(serve) / …の速度で進む,距離を行く / …‘を'見物する / 〈劇〉‘を'上演する;…‘の'役を演じる / …の役目(仕事)をする / 《おもに英》…‘を'だます,かつぐ / 《話》…をへとへとにさせる / 『する』;活動する / 《通例have done,時にbe doneの形で》(…を)『終える』,済ます《+『with』+『名』》 / 〈事が〉『運ぶ』;〈人が〉暮らしていく,健康である / 〈物が〉(…に)『間に合う』,十分である;〈人が〉(…に)役に立つ,向く《+『for』+『名』》 / 《複数形で》すべきこと / 〈C〉《おもに英》大宴会,大パーティー / 〈C〉《英話》詐欺,ぺてん
- ド(全音階の第1音)
- 〈C〉『規則』,『規定』;法規,条例 / 〈U〉(…の)『規制』,『調整』《+『of』+『名』》 / 正規の,規定どおりの
UpToDate Contents
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English Journal
- Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.
- Pereira-Caro G, Mateos R, Traka MH, Bacon JR, Bongaerts R, Sarriá B, Bravo L, Kroon PA.SourceInstitute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK; IFAPA, Centro Venta del Llano, Road Bailén-Motril, Km 18.5, 23620 Mengibar (Jaén), Spain.
- Food chemistry.Food Chem.2013 Jun 1;138(2-3):1172-82. doi: 10.1016/j.foodchem.2012.11.118. Epub 2012 Dec 5.
- The anticarcinogenic activity of hydroxytyrosyl ethyl ether (HTy-Et) compared to its precursor hydroxytyrosol (HTy) has been studied in human Caco-2 colon adenocarcinoma cells. 451 and 977 genes were differentially expressed in Caco-2 cells exposed to HTy or HTy-Et for 24h, respectively, compared wi
- PMID 23411228
- miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin.
- Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Egawa S, Motoi F, Unno M, Shimosegawa T.SourceDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan. hamadas@med.tohoku.ac.jp.
- Journal of cellular physiology.J Cell Physiol.2013 Jun;228(6):1255-63. doi: 10.1002/jcp.24280.
- Invasive ductal adenocarcinoma (IDA) of the pancreas manifests poor prognosis due to the early invasion and distant metastasis. In contrast, intraductal papillary mucinous adenoma or carcinoma (IPMA or IPMC) reveals better clinical outcomes. Various molecular mechanisms contribute to these differenc
- PMID 23139153
Japanese Journal
- Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.
- Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling
- The ERF transcription factor EPI1 is a negative regulator of dark-induced and jasmonate-stimulated senescence in Arabidopsis
Related Links
- Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation. An example of ...
- down-regulation /down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent.
★リンクテーブル★
[★]
- 英
- down-regulation, down regulation
- 同
- 下向き調節
[★]
- 関
- decline、decrease、diminish、diminution、down-regulate、downmodulation、downregulate、downregulation、fall、loss、receptor down-regulation、reduce、reduction
[★]
- 関
- down-regulation、downregulation
[★]
- 関
- accommodation、accommodative、adjust、adjustment、baffle、control、modulate、modulation、regulate、regulatory
[★]
- 関
- carry out、conduct、execute、make、perform、practice、undertake
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