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English Journal

Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice.

Nehar-Belaid D1, Courau T1, Dérian N1, Florez L1, Ruocco MG1, Klatzmann D2.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Jan 15;196(2):678-90. doi: 10.4049/jimmunol.1501834. Epub 2015 Dec 7.
Embryos and tumors are both masses of dividing cells expressing foreign Ags, but they are not rejected by the immune system. We hypothesized that similar tolerogenic mechanisms prevent their rejection. Global comparison of fetal and tumor microenvironments through transcriptomics in mice revealed st
PMID 26643476

Downregulation of GABAA Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia.

Mele M1,2, Aspromonte MC1,3, Duarte CB4,5.
Molecular neurobiology.Mol Neurobiol.2016 Jan 5. [Epub ahead of print]
Downregulation of GABAergic synaptic transmission contributes to the increase in overall excitatory activity in the ischemic brain. A reduction of GABAA receptor (GABAAR) surface expression partly accounts for this decrease in inhibitory activity, but the mechanisms involved are not fully elucidated
PMID 26732589

Molecular imaging of aurora kinase A (AURKA) expression: Synthesis and preclinical evaluation of radiolabeled alisertib (MLN8237).

Goos JA1, Verbeek J2, Geldof AA3, Hiemstra AC4, van de Wiel MA5, Adamzek KA3, Delis-Van Diemen PM4, Stroud SG6, Bradley DP6, Meijer GA7, Hoekstra OS3, Fijneman RJ7, Windhorst AD3.
Nuclear medicine and biology.Nucl Med Biol.2016 Jan;43(1):63-72. doi: 10.1016/j.nucmedbio.2015.08.007. Epub 2015 Sep 11.
INTRODUCTION: Survival of patients after resection of colorectal cancer liver metastasis (CRCLM) is 36%-58%. Positron emission tomography (PET) tracers, imaging the expression of prognostic biomarkers, may contribute to assign appropriate management to individual patients. Aurora kinase A (AURKA) ex
PMID 26432753