Physiology & behavior.Physiol Behav.2014 Jun 10;132:1-9. doi: 10.1016/j.physbeh.2014.03.033. Epub 2014 May 5.
When tested on the treadmill mice do not display a graded increase of heart rate (HR), but rather a sharp shift of cardiovascular indices to high levels at the onset of locomotion. We hypothesized that under test conditions cardiovascular reaction to physical load in mice is masked with stress-assoc
A new activity of N-cholinolytic drug benzohexonium.
Khnychenko LK1, Okunevich IV, Losev NA, Sapronov NS, Yakovleva EE.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Aug;153(4):487-9.
We have found that N-cholinolytic drug benzohexonium produces a hypolipidemic effect: it reduces dyslipoproteinemia, fatty infiltration of the liver, and risk of atherosclerotic lesions.
Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice.
Socała K1, Nieoczym D, Wyska E, Poleszak E, Wlaź P.
Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm.2012 Jun;119(6):645-52. doi: 10.1007/s00702-011-0756-9. Epub 2012 Jan 4.
The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine receptors in the neurobiology of mood disorders. The present study was designed to investigate the effect of sildenafil, a phosphodiesterase type 5 inhibitor which exhibits cholinomimetic properties, alone an
Molecular Orbital Interpretations for Cholinergic Activities of Some Alkyltrialkylammonium Derivatives
木村 郁子,森島 績,米沢 貞次郎,木村 正康
Chemical & pharmaceutical bulletin 22(2), 429-432, 1974-02-25
… The electronic structures of alkyltrialkylammonium derivatives were studied by the CNDO/2 method, and cholinomimetic and cholinolytic activities of these compounds were discussed. …
cholinolytic /cho·li·no·lyt·ic/ (-lit´ik). 1. blocking the action of acetylcholine, or of cholinergic agents. 2. an agent that blocks the action of acetylcholine in cholinergic areas, i.e., organs supplied by parasympathetic nerves, and voluntary muscles.