WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
in or near a center or constituting a center; the inner area; "a central position"
a workplace that serves as a telecommunications facility where lines from telephones can be connected together to permit communication (同)telephone exchange, exchange
easily agitated; "a nervous addict"; "a nervous thoroughbred"
of or relating to the nervous system; "nervous disease"; "neural disorder" (同)neural
severe respiratory disease of birds that takes the form of an acute rapidly fatal pneumonia in young chickens and turkeys (同)brooder pneumonia
an opportunistic infection by a fungus of the genus Aspergillus; characterized by inflammation and lesions of the ear and other organs
disease especially in agricultural workers caused by inhalation of Aspergillus spores causing lumps in skin and ears and respiratory organs

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
『中心の』,中央の,中心からの / 『主要な』,中心的な(main) / (音声が)中舌音の / 電話交換局(《英》[telephone]exchange)
『神経の』 / 『神経質な』,神経過敏な / 『心配な』,不安な

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1. 侵襲性アスペルギルス症の疫学および臨床症状 epidemiology and clinical manifestations of invasive aspergillosis
2. 中枢神経系病変を有するHIV感染患者に対するアプローチ approach to hiv infected patients with central nervous system lesions
3. 成人における中枢神経系の原発性血管炎 primary angiitis of the central nervous system in adults
4. ノカルジア症の臨床症状および診断 clinical manifestations and diagnosis of nocardiosis
5. 脳膿瘍の病因、臨床症状、および診断 pathogenesis clinical manifestations and diagnosis of brain abscess

English Journal

Dose-independent confusion induced by voriconazole in a patient with Asian ancestry after allogeneic hematopoietic stem cell transplant.

Hui J1.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.J Oncol Pharm Pract.2016 Feb;22(1):175-8. doi: 10.1177/1078155214549491. Epub 2014 Sep 1.
This is the case of a 71-year-old man with Asian ancestry who had myelodysplastic syndrome admitted for allogeneic hematopoietic stem cell transplant. This case suggests that voriconazole-induced confusion is probably dose-independent and reversible with no residual symptoms after discontinuation of
PMID 25178697

Chronic Invasive Aspergillus Sinusitis and Otitis with Meningeal Extension Successfully Treated with Voriconazole.

Morgand M1, Rammaert B1, Poirée S2, Bougnoux ME3, Tran H4, Kania R4, Chrétien F5, Jouvion G6, Lortholary O7.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Dec;59(12):7857-61. doi: 10.1128/AAC.01506-15. Epub 2015 Sep 21.
Invasive aspergillosis (IA) is a severe disseminated fungal disease that occurs mostly in immunocompromised patients. However, central nervous system IA, combining meningitis and skull base involvement, does not occur only in groups with classic risk factors for IA; patients with chronic renal failu
PMID 26392507

VORICONAZOLE TOXICITY IN MULTIPLE PENGUIN SPECIES.

Hyatt MW, Georoff TA, Nollens HH, Wells RL, Clauss TM, Ialeggio DM, Harms CA, Wack AN.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.J Zoo Wildl Med.2015 Dec;46(4):880-8. doi: 10.1638/2015-0128.1.
Aspergillosis is a common respiratory fungal disease in penguins managed under human care. Triazole antifungal drugs, including itraconazole, are most commonly used for treatment; however, itraconazole treatment failures from drug resistance are becoming more common, requiring newer treatment option
PMID 26667545

Japanese Journal

侵襲型アスペルギルス症による眼窩先端症候群を発症し頭蓋内へ病巣の拡大がみられた2型糖尿病の1例

横田純子,佐藤淳子,荒川敦 [他],栗﨑愛子,大村千恵,金澤昭雄,弘世貴久,藤谷与士夫,綿田裕孝
糖尿病 57(9), 699-705, 2014
症例は58歳の女性．右眼瞼下垂を主訴に近所の脳神経内科専門医を受診し2型糖尿病と糖尿病による動眼神経麻痺と診断され内服加療が開始された．その後，右眼の視力低下がありMRIで眼窩内の腫瘍を認めたが生検を拒否したため経過観察となった．3か月後，視力低下により食事摂取量が低下，全身状態不良で当院に緊急入院した．入院時のMRIで眼窩内の腫瘍の頭蓋内浸潤を認めたため入院直後は脳浮腫や，肉芽腫などの炎症性疾患 …
NAID 130004696300

深在性真菌感染症に腫瘍関連血球貪食症候群を合併した難治性急性骨髄性白血病

山田愛,盛武浩,澤大介,下之段秀美,児嶋ひとみ,上村幸代,布井博幸
臨床血液 54(4), 383-387, 2013
症例は2歳女児。髄外浸潤を伴うMLL遺伝子再構成陽性急性骨髄性白血病(AML)を発症した。MLL遺伝子の融合相手としてMLLT10を分離した。治療終了2ヵ月後に骨髄と中枢神経系の複合再発をきたし，再寛解導入療法を施行するも血球貪食症候群(HLH)と侵襲性肺アスペルギルス症(IPA)を合併した。抗真菌剤投与で感染コントロール良好となってもHLHは改善せず，骨髄生検検体でMLL-MLLT10遺伝子が検 …
NAID 130004501805