血斑

WordNet

mark with a spot or spots so as to allow easy recognition; "spot the areas that one should clearly identify"
a small piece or quantity of something; "a spot of tea"; "a bit of paper"; "a bit of lint"; "I gave him a bit of my mind" (同)bit
a small contrasting part of something; "a bald spot"; "a leopards spots"; "a patch of clouds"; "patches of thin ice"; "a fleck of red" (同)speckle, dapple, patch, fleck, maculation
a business establishment for entertainment; "night spot"
a playing card with a specified number of pips on it to indicate its value; "an eight-spot"
a mark on a die or on a playing card (shape depending on the suit) (同)pip
a section of an entertainment that is assigned to a specific performer or performance; "they changed his spot on the program"
a short section or illustration (as between radio or tv programs or in a magazine) that is often used for advertising
make a spot or mark onto; "The wine spotted the tablecloth" (同)fleck, blob, blot
detect with the senses; "The fleeing convicts were picked out of the darkness by the watchful prison guards"; "I cant make out the faces in this photograph" (同)recognize, recognise, distinguish, discern, pick out, make_out, tell apart
become spotted; "This dress spots quickly"
smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
temperament or disposition; "a person of hot blood"
people viewed as members of a group; "we need more young blood in this organization"
the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea

PrepTutorEJDIC

『斑点』(はんてん),まだら,ぶち;(太陽の)黒点 / 『しみ』,よごれ;吹出物,にきび / (…に対する)汚名,汚点《+『on』+『名』》 / 『場所』,地点;部分,箇所 / (順序・組織における)位置;立場,おかれた状況 / 《a spot》《英話》(…の)少量,ちょっぴり(の…);(…の)1杯《+『of』+『名』》 / (ラジオ・テレビ番組の)構成区分 / …‘を'『しみで汚す』,‘に'汚れをつける;…‘に'斑点(はんてん)をつける,‘を'まだら(ぶち)にする;( …で)…‘に'しみ(斑点)をつける《+『名』+『with』+『名』》 / 〈人格・名声など〉‘を'汚す,傷つける / (特定の場所に)…‘を'置く,配置する / …‘を'見つける;(…だと)…‘を'見抜く《+『名』+『as』(『for』)+『名』》 / 〈インクなどが〉『しみになる』;〈布などが〉汚れる / 即座になされる,即時払いの(引き渡しの) / 現場での,現地の / (ラジオ・テレビで)番組の間に放送される / ちょうど,ぴったり(exactly)
『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す

UpToDate Contents

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1. 特発性脳出血：治療および予後 spontaneous intracerebral hemorrhage treatment and prognosis
2. 新生児スクリーニング newborn screening
3. 限局性結腸病変に対する点墨およびその他の方法 tattooing and other methods for localizing colonic lesions
4. Congenital cytomegalovirus infection: Clinical features and diagnosis
5. Acquired cytomegalovirus infection in infants, children, and adolescents

English Journal

Uptake of hepatitis C treatment among people who inject drugs attending Needle and Syringe Programs in Australia, 1999-2011.

Iversen J, Grebely J, Topp L, Wand H, Dore G, Maher L.Author information Viral Hepatitis Epidemiology and Prevention Program, The Kirby Institute University of New South Wales, Sydney, NSW, Australia.AbstractThe majority of new and existing cases of hepatitis C virus (HCV) infection occur among people who inject drugs (PWID). Despite safe and efficacious HCV antiviral therapy, uptake remains low in this population. This study examined trends in HCV treatment uptake among a large national sample of PWID attending Australian Needle and Syringe Programs between 1999 and 2011. Annual cross-sectional sero-surveys conducted among PWID since 1995 involve completion of a self-administered questionnaire and provision of a dried blood spot for HCV antibody testing. Multivariate logistic regression identified variables independently associated with HCV treatment uptake among 9478 participants with both self-reported and serologically confirmed prior HCV infection. Between 1999 and 2011, the proportion currently receiving treatment increased from 1.1% to 2.1% (P < 0.001), while the proportion having ever received treatment increased from 3.4% to 8.6% (P < 0.001). Men were significantly more likely than women to have undertaken HCV treatment (P = 0.002). Among men, independent predictors of HCV treatment uptake were homosexual identity and older age; among women, independent predictors included homosexual identity and an incarceration history. Despite increases in HCV treatment among Australian PWID between 1999 and 2011, uptake remains low. Strategies are required to increase the proportion of PWID assessed and treated for HCV infection to address the increasing burden of disease. Specific approaches that target women may also be warranted. Continued surveillance of HCV treatment uptake among PWID will be important to monitor the roll-out of simple, safe and more effective HCV treatments expected to be available in the future.
Journal of viral hepatitis.J Viral Hepat.2014 Mar;21(3):198-207. doi: 10.1111/jvh.12129. Epub 2013 Jul 1.
The majority of new and existing cases of hepatitis C virus (HCV) infection occur among people who inject drugs (PWID). Despite safe and efficacious HCV antiviral therapy, uptake remains low in this population. This study examined trends in HCV treatment uptake among a large national sample of PWID
PMID 24438681

Development of a feasible assay for the detection of GAA mutations in patients with Pompe disease.

Er TK1, Chen CC2, Chien YH3, Liang WC4, Kan TM5, Jong YJ6.Author information 1Division of Molecular Diagnostics, Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan; Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: tzekiong@totalbb.net.tw.2Institute of Bioinformatics and Systems Biology, College of Biological Science and Technology, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu 30068, Taiwan; Center for Lipid Biosciences, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 195, Sec. 4, Chung Hsing Rd., Hsinchu 31040, Taiwan. Electronic address: chieh.bi91g@nctu.edu.tw.3Department of Medical Genetics and Pediatrics, National Taiwan University Hospital, Taipei 10041, Taiwan. Electronic address: chienyh@ntu.edu.tw.4Center for Lipid Biosciences, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan. Electronic address: peggieliang@yahoo.com.tw.5Department of Pediatrics, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan. Electronic address: nekokan1983@yahoo.com.tw.6Division of Molecular Diagnostics, Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: yjjong@gap.kmu.edu.tw.AbstractBACKGROUND: Pompe disease is an inherited autosomal recessive deficiency of acid α-glucosidase (GAA) and is due to pathogenic sequence variants in the corresponding GAA gene. While the analysis of enzyme activity remains the diagnostic test of choice for individuals with Pompe disease, mutation analysis remains for establishing a definitive diagnosis.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2014 Feb 15;429:18-25. doi: 10.1016/j.cca.2013.10.013. Epub 2013 Oct 24.
BACKGROUND: Pompe disease is an inherited autosomal recessive deficiency of acid α-glucosidase (GAA) and is due to pathogenic sequence variants in the corresponding GAA gene. While the analysis of enzyme activity remains the diagnostic test of choice for individuals with Pompe disease, mutation ana
PMID 24444888

Measurement of succinyl-carnitine and methylmalonyl-carnitine on dried blood spot by liquid chromatography-tandem mass spectrometry.

Rizzo C1, Boenzi S2, Inglese R1, la Marca G3, Muraca M1, Martinez TB4, Johnson DW5, Zelli E1, Dionisi-Vici C6.Author information 1Department of Laboratory Medicine, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.2Division of Metabolism and Research Unit of Metabolic Biochemistry, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy. Electronic address: sara.boenzi@opbg.net.3NeuroFarba Department, University of Florence, Florence, Italy; Newborn Screening Lab, Clinic of Pediatric Neurology, AOU Meyer, Florence, Italy.4Bioquimica Clinica y Istituto de Genetica Medica y Molecular, Hospital Universitario La Paz, Madrid, Spain.5Department of Chemical Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.6Division of Metabolism and Research Unit of Metabolic Biochemistry, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.AbstractMethylmalonic aciduria (MMA) is one of the most frequent organic acidurias, a class of diseases caused by enzymatic defects mainly involved in the catabolism of branched-chain amino acids. Recently, mild MMA and C4-dicarboxylyl-carnitine (C4DC-C) accumulation have been reported in patients carrying mutation in genes encoding the α-subunit (SUCLG1) and the β-subunit (SUCLA2) of the ADP-forming succinyl-CoA synthetase (SCS). We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify in dried blood spot the two isobaric compounds of C4DC-C, succinyl-carnitine and methylmalonyl-carnitine, to allow the differential diagnosis between classical MMA and SCS-related defects. This method, with an easy liquid-phase extraction and derivatization procedure, has been validated to demonstrate the specificity, linearity, recovery, lowest limit of quantification (LLOQ), accuracy and precision for quantitative determination of blood succinyl-carnitine and methylmalonyl-carnitine. The assay was linear over a concentration range of 0.025-10μmol/L and achieved the LLOQ of 0.025μmol/L for both metabolites. The average slope, intercept, and coefficient of linear regression (r(2)) were respectively: 0.3389 (95% confidence interval 0.2888-0.3889), 0.0113 (95% confidence interval -0.0157 to 0.0384), 0.9995 (95% confidence interval 0.9990-1.0000) for succinyl-carnitine and 0.5699 (95% confidence interval 0.5263-0.6134), 0.0319 (95% confidence interval -0.0038 to 0.0677), 0.9997 (95% confidence interval 0.9995-1.0000) for methylmalonyl-carnitine. Within-day and between-day coefficients of variation (CV) were 1.94% and 3.19% for succinyl-carnitine and 3.21%, and 2.56 for methylmalonyl-carnitine. This method is accurate and provides a new tool to differentiate patients with classical methylmalonic acidemia from those with SCS-related defects.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2014 Feb 15;429:30-3. doi: 10.1016/j.cca.2013.11.016. Epub 2013 Nov 22.
Methylmalonic aciduria (MMA) is one of the most frequent organic acidurias, a class of diseases caused by enzymatic defects mainly involved in the catabolism of branched-chain amino acids. Recently, mild MMA and C4-dicarboxylyl-carnitine (C4DC-C) accumulation have been reported in patients carrying
PMID 24269713

Japanese Journal

Development of Endovascular Therapy for Intracranial Aneurysms

OISHI HIDENORI
順天堂醫事雑誌 61(3), 228-234, 2015
… Because the aneurysm has a weakened spot, there is a risk of rupture. … When the microcatheter has been inserted into the aneurysm, platinum coils are inserted to occupy the aneurysm cavity, which prevents blood flow into the aneurysm. …
NAID 130005103849

破裂性腹部大動脈瘤に対してEVAR およびダメージコントロールサージェリーを施行した1 例

石井廣人,中村都英,長濱博幸,松山正和,遠藤穣治,西村征憲
日本血管外科学会雑誌 advpub(0), 2015
要旨：症例は78 歳，男性．意識障害・腹痛で発症し，当院搬送後に造影CT にて破裂性腹部大動脈瘤の診断となり緊急でステントグラフト内挿術（EVAR）を施行した．術中に腹腔内への再破裂を呈したが急速輸液と大動脈閉塞バルーンの使用で重篤なショック状態は回避できた．EVAR 後，腹部コンパートメント症候群を呈していたため速やかに開腹して減圧を行った．また最終造影ではエンドリークを認めなかったが腹腔内の持 …
NAID 130005102959

タンデム型質量分析計を用いた新生児マススクリーニングの現状について（埼玉県における2年3か月間の実施報告）

三井規雅,熊谷望美,鈴木ななみ,岡田智香子,油座博文
医学検査 64(4), 405-412, 2015
埼玉県では2012年10月より母子保健事業の一環としてタンデム型質量分析計による新生児マススクリーニングを開始した。2014年12月までの2年3か月間で埼玉県内にて出生した新生児105,905人の検査を実施した。その結果，精密検査となった32例のうち専門医療機関を受診し最終的に患児と診断されたのは14例（アミノ酸代謝異常症6例，有機酸代謝異常症2例，脂肪酸代謝異常症6例）であり，患児発見率は1/7 …
NAID 130005098762