active renin concentration

活性型レニン濃度

WordNet

1. a person who is a participating member of an organization; "the club issues a list of members, both the actives and the retirees"
2. tending to become more severe or wider in scope; "active tuberculosis"
3. in operation; "keep hope alive"; "the tradition was still alive"; "an active tradition" (同)alive
4. engaged in or ready for military or naval operations; "on active duty"; "the platoon is combat-ready"; "review the fighting forces" (同)combat-ready, fighting
5. (used of verbs (e.g. `to run' (同)dynamic
6. taking part in an activity; "an active member of the club"; "he was politically active"; "the participating organizations" (同)participating
7. (of e.g. volcanos) capable of erupting
8. (of e.g. volcanos) erupting or liable to erupt; "active volcanos"
9. (of the sun) characterized by an increased occurrence of sunspots and flares and radio emissions
10. characterized by energetic activity; "an active toddler"; "active as a gazelle"; "an active man is a man of action"
11. disposed to take action or effectuate change; "a director who takes an active interest in corporate operations"; "an active antagonism"; "he was active in drawing attention to their grievances"
12. engaged in full-time work; "active duty"; "though past retirement age he is still active in his profession"
13. exerting influence or producing a change or effect; "an active ingredient"
14. expressing that the subject of the sentence has the semantic function of actor: "Hemingway favors active constructions"
15. full of activity or engaged in continuous activity; "an active seaport"; "an active bond market"; "an active account"
16. the spatial property of being crowded together (同)density, denseness, tightness, compactness
17. bringing together military forces
18. strengthening the concentration (as of a solute in a mixture) by removing diluting material
19. the strength of a solution; number of molecules of a substance in a given volume
20. complete attention; intense mental effort (同)engrossment, absorption, immersion
21. increase in density
22. a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure

PrepTutorEJDIC

1. 『活動的な』,活発な,活気のある / 『有効な』,(薬の効力などが)まだ働いている,機能している / (軍務で)現役の / 『積極的な』,実際的な / 能動態の
2. 〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度

UpToDate Contents

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• 1. 副腎疾患におけるレニン-アンギオテンシン-アルドステロン系の評価 assays of the renin angiotensin aldosterone system in adrenal disease
• 2. 高血圧治療におけるレニン・アンギオテンシン系阻害 renin angiotensin system inhibition in the treatment of hypertension
• 3. Chapter 2B：レニン－アンギオテンシン系 chapter 2b renin angiotensin system
• 4. 低カリウム血症を合併した高血圧症へのアプローチ approach to the patient with hypertension and hypokalemia
• 5. 低レニン性原発性（本態性）高血圧 low renin primary essential hypertension

English Journal

• Measurement of plasma renin concentration instead of plasma renin activity decreases the positive aldosterone-to-renin ratio tests in treated patients with essential hypertension.

• Lonati C1, Bassani N, Gritti A, Biganzoli E, Morganti A.Author information 1aDepartment of Internal Medicine and Hypertension Center, Ospedale San Giuseppe, Istituto Ricovero e Cura a Carattere Scientifico (IRCCS) Multimedica, Department of Clinical Sciences and Community Health bUnit of Medical Statistics, Biometry and Bioinformatics, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.AbstractBACKGROUND: The plasma aldosterone-to-renin ratio (ARR) for the diagnosis of primary aldosteronism is normally calculated with plasma renin activity (PRA) as denominator. However, new direct renin assays that measure plasma renin concentration (PRC) are progressively replacing PRA because these are faster, simpler, and more reproducible.
• Journal of hypertension.J Hypertens.2014 Mar;32(3):627-34. doi: 10.1097/HJH.0000000000000076.
• BACKGROUND: The plasma aldosterone-to-renin ratio (ARR) for the diagnosis of primary aldosteronism is normally calculated with plasma renin activity (PRA) as denominator. However, new direct renin assays that measure plasma renin concentration (PRC) are progressively replacing PRA because these are
• PMID 24445391

• Efficacy and Safety Profile of Aliskiren: Practical Implications for Clinicians.

• Angeli F, Reboldi G, Poltronieri C, Angeli E, De Filippo V, Crocetti A, Bartolini C, D'Ambrosio C, Verdecchia P1.Author information 1Division of Cardiology and Cardiovascular Pathophysiology, Teaching Hospital "S.M. della Misericordia", Perugia, Italy. fangeli@cardionet.it.AbstractRenin-angiotensin-system (RAS) is an enzymatic cascade that plays a pivotal role in the development of arterial hypertension, kidney disease and cardiovascular disease. Inhibition of the RAS with angiotensin converting enzyme (ACE) inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) has proved to be a successful strategy for the treatment of hypertension and related cardiovascular disorders. However, by reducing feedback inhibition of renin release, the effects of ACE-Is and ARBs lead to an increase in plasma renin concentration (PRC) and activity (PRA), limiting a complete inhibition of the RAS. Consequently the effects of a different pharmacological strategy that completely blocks the RAS upstream has been assessed in the last years. In this context, aliskiren is the first representative of a new class of non-peptide orally active renin inhibitor that blocks the RAS at its rate-limiting step and induces a net reduction in PRA, angiotensin II and aldosterone levels. Aliskiren effectively reduces blood pressure as a monotherapy as well in combination therapy. In addition, aliskiren has a placebo-like tolerability profile at the licensed doses of 150 mg and 300 mg. Aliskiren also exhibits additive effects on blood pressure reduction when combined with drugs that lead to a reactive increase in the PRA, such as diuretics, ACE-Is or ARBs. In previous studies, aliskiren showed beneficial effects in patients with arterial hypertension and associated clinical conditions. However, later trials indicated that the use of aliskiren should be avoided in patients with renal failure or receiving ACE-Is or ARBs. The main aim of this review is to summarize the available data on its efficacy and safety profile, highlighting clinical implications from recent trials.
• Current drug safety.Curr Drug Saf.2014 Feb 10. [Epub ahead of print]
• Renin-angiotensin-system (RAS) is an enzymatic cascade that plays a pivotal role in the development of arterial hypertension, kidney disease and cardiovascular disease. Inhibition of the RAS with angiotensin converting enzyme (ACE) inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) has prov
• PMID 24517108

• End-organ damage in urbanized Africans with low plasma renin levels: the SABPA study.

• van Rooyen JM1, Schutte AE, Huisman HW, Schutte R, Fourie CM, Malan NT, Malan L.Author information 1Hypertension in Africa Research Team (HART), North-West University , Potchefstroom , South Africa.AbstractThe purpose of this study was to evaluate whether active renin concentration is associated with markers of end-organ damage in urbanized Africans. This study forms part of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. For this study, 81 men and 74 women were divided into low- and high-renin groups. Ambulatory blood pressure measurements were conducted. A resting 12-lead ECG was determined in order to determine the gender-specific Cornell voltage. Cardiovascular variables were continuously recorded with the Finometer. Carotid-dorsalis pedis pulse wave velocity was obtained with the Complior acquisition system. The carotid intima-media thickness (CIMT) was obtained with the SonoSite MicroMaxx. Blood samples were collected; serum and plasma were stored at -80 °C for analysis. Anthropometric measurements were taken using standard methods. A general health questionnaire was also completed. The urinary creatinine was determined with a calorimetric method and albumin with a turbidimetric method. The serum sodium and potassium were determined by making use of the Konelab TM 20i Sequential Multiple Analyzer Computer (SMAC). The concentration of active renin in the plasma was analyzed by making use of a high-sensitivity radio-immunometric assay. A negative association (r=-0.29, p<0.01) exists between renal function (ACR) and plasma renin in the low-renin group (<6.18 pg/mL), which was not observed in Africans with high-renin levels. It seems evident that low renin in black South Africans may result in sub-clinical renal damage and impaired vascular function in a group of urbanized black South Africans.
• Clinical and experimental hypertension (New York, N.Y. : 1993).Clin Exp Hypertens.2014;36(1):70-5. doi: 10.3109/10641963.2013.789044. Epub 2013 Jun 20.
• The purpose of this study was to evaluate whether active renin concentration is associated with markers of end-organ damage in urbanized Africans. This study forms part of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. For this study, 81 men and 74 women were divid
• PMID 23786427

Japanese Journal

• 血漿レニン活性(PRA)と活性型レニン濃度(ARC) (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (内分泌学的検査 その他)

• 田村 功一,前田 晃延
• 日本臨床 68(-), 601-607, 2010-07
• NAID 40017200820

• Decreased Expression of Angiotensin-Converting Enzyme 2 in Pancreatic Ductal Adenocarcinoma Is Associated with Tumor Progression

• , , , , , , ,
• The Tohoku Journal of Experimental Medicine 217(2), 123-131, 2009
• … Angiotensin II (ANG II), the biologically active peptide of the renin-angiotensin system (RAS), is generated by angiotensin-converting enzyme (ACE) and is a regulator of cardiovascular homeostasis. … The ANG II concentration in homogenates of pancreatic tissues was measured with ELISA, and ACE2 protein was detected by Western blot analysis in BxPC3 and SW1990 human pancreatic ductal cancer cells. …
• NAID 130004822148

• 11β-HSD2活性阻害による鉱質コルチコイド過剰症と考えられる87歳女性

• 稲田 満夫
• 日本老年医学会雑誌 44(4), 513-516, 2007-07-25
• 87歳の女性．四肢筋力低下のため，起立歩行は不可能，食事に介助が必要となり入院した．高血圧，低K血症(2.7mEq/l），代謝性アルカローシスを認め，一方，尿中K排泄量は20mEq/日以上で，鉱質コルチコイド過剰症と考えられた．甘草配合漢方薬の服用中止約3カ月後も低K血症は持続し，血漿レニン活性0.2ng/ml/時以下，アルドステロン32pg/ml，尿中アルドステロン1.1μg/日と著明に低下して …
• NAID 10019832434

Related Links

• 活性型レニン定量, ARC （active renin concentration）

活性型レニン定量, ARC （active renin concentration） 測定法： IRMA法（ビーズ固相法） 外注会社： LSIM（平成26年4月1日より社名変更）MCM(平成18年6月27日よりMBC；平成19年4月1日より社名変更）（平成18年6月26日 ...

• Active renin mass concentration to determine aldosterone-to ...

Active renin mass concentration (ARC) is independent of the endogenous level of angiotensinogen, and less variable and more reproducible than plasma renin activity. Reference values for the aldosterone-to-renin ratio ...

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★リンクテーブル★

リンク元	「活性型レニン濃度」
関連記事	「active」「concentration」

「活性型レニン濃度」

　　[★]

英

active renin concentration, ARC

関

レニン活性測定

「active」

　　[★]

• adj.

• 活動性の、活動期の、活動的な、行動的な、積極的な、活発な、能動的な、有効な、アクティブな

関

active stage、actively、activity、aggressive、behaviorally、brisk、briskly、effective、efficacious、offensive、positive、positively、valid、vigorous、vigorously

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「concentration」

　　[★]

• n.

• 濃度、濃縮、(精神の)集中

関

attention、attentive、centralize、conc.、concentrate、concentrated、condensation、enrich、enrichment、focus