- 関
- accelerated phase myeloid leukemia、aggressive-phase myeloid leukemia
WordNet
- arrange in phases or stages; "phase a withdrawal"
- (physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; "the reaction occurs in the liquid phase of the system" (同)form
- a particular point in the time of a cycle; measured from some arbitrary zero and expressed as an angle (同)phase_angle
- any distinct time period in a sequence of events; "we are in a transitional stage in which many former ideas must be revised or rejected" (同)stage
- adjust so as to be in a synchronized condition; "he phased the intake with the output of the machine"
- (astronomy) the particular appearance of a bodys state of illumination (especially one of the recurring shapes of the part of Earths moon that is illuminated by the sun); "the full phase of the moon"
- being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
- of long duration; "chronic money problems" (同)continuing
- habitual; "a chronic smoker" (同)inveterate
- cause to move faster; "He accelerated the car" (同)speed, speed up
- move faster; "The car accelerated" (同)speed up, speed, quicken
- of or relating to the spinal cord
- of or relating to bone marrow
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
PrepTutorEJDIC
- (変化・発達の)『段階』,『局面』 / (物事の)『面』,様相《+『of』+『名』》 / (月・惑星などの)相 / …‘を'段階的に調整(整理)する
- (病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
- …‘の'速度を速める,加速する / 〈ある状態〉'を'早く起こさせる / 速くなる,速度を増す
- 白血病
UpToDate Contents
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English Journal
- Dasatinib: A Guide to Its Use in Chronic Myeloid Leukemia in the EU.
- Keating GM, Lyseng-Williamson KA, McCormack PL, Keam SJ.SourceAdis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, demail@springer.com.
- BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.BioDrugs.2013 Apr 3. [Epub ahead of print]
- Oral dasatinib (Sprycel®) is effective in the treatment of patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML) or imatinib-resistant or imatinib-intolerant chronic-phase, accelerated-phase, or blast-phase CML. In particular, dasatinib is associated with better and faster resp
- PMID 23549840
- Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia.
- Stein AM, Martinelli G, Hughes TP, Müller MC, Beppu L, Gottardi E, Branford S, Soverini S, Woodman RC, Hochhaus A, Kim DW, Saglio G, Radich JP.AbstractBACKGROUND: We evaluated BCR-ABL1 kinetics in patients treated with nilotinib and analyzed whether a dynamic model of changes in BCR-ABL1 levels over time could be used to predict long-term responses.
- BMC cancer.BMC Cancer.2013 Apr 2;13(1):173. [Epub ahead of print]
- BACKGROUND: We evaluated BCR-ABL1 kinetics in patients treated with nilotinib and analyzed whether a dynamic model of changes in BCR-ABL1 levels over time could be used to predict long-term responses.METHODS: Patients from the nilotinib registration trial (CAMN107A2101; registered at www.clinicaltri
- PMID 23547655
- Evaluation of T315I mutation frequency in chronic myeloid leukemia patients after imatinib resistance.
- Chahardouli B, Zaker F, Mousavi SA, Kazemi A, Ostadali M, Nadali F, Rostami S, Alimoghaddam K, Ghavamzade A.AbstractThe occurrence of resistance mutations in the Abl kinase domain plays a central role in drug treatment failure in chronic myeloid leukemia (CML) patients. Among them, the T315I mutation at the gatekeeper position affects a common Abl kinase contact residue and confers complete resistance to all known ATP-competitive BCR-ABL inhibitors. In the present study, an allele-specific oligonucleotide reverse transcriptase polymerase chain reaction assay was used to detect T315I mutation in a cohort of 60 imatinib-resistant CML patients. In terms of disease phase, 43 patients (71%) were in late chronic phase, 4 (7%) in accelerated phase, and 13 (22%) in blastic phase. The prevalence of the T315I mutation was found to be 7% (4/60). All four patients with mutation were in advance phases and had previously lost all their responses. The results of the study confirmed that this method is low cost and easy tool to operate for T315I mutation screening and direct sequencing should be performed in positive cases for confirmation.
- Hematology (Amsterdam, Netherlands).Hematology.2013 Mar 27. [Epub ahead of print]
- The occurrence of resistance mutations in the Abl kinase domain plays a central role in drug treatment failure in chronic myeloid leukemia (CML) patients. Among them, the T315I mutation at the gatekeeper position affects a common Abl kinase contact residue and confers complete resistance to all know
- PMID 23540562
Japanese Journal
- チロシンキナーゼ阻害剤による細胞遺伝学的部分寛解期にPh陰性急性骨髄性白血病を発症したminor-BCR/ABL陽性慢性骨髄性白血病
- 藤井 総一郎,三浦 偉久男,田中 英夫
- 臨床血液 56(6), 681-686, 2015
- 症例は78歳，男性。CKDと慢性心不全の治療中に白血球増多を指摘され当科を受診した。Ph染色体と付加的染色体異常を持ち芽球が12%, FISH検査でBCR/ABL融合シグナルを認め，RT-PCR法ではm-BCR/ABLが高値であったためm-BCR/ABL陽性CML（移行期）と診断した。Imatinibに治療抵抗性であったため治療をnilotinibへ変更した。貧血と心不全が悪化したためniloti …
- NAID 130005093102
- Successful treatment with nilotinib for molecular relapse of chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation in the accelerated phase
- Ota Shuichi,Imai Kiyotoshi,Ara Takahide,Ogasawara Reiki,Minauchi Koichiro,Hirano Teiichi,Ogasawara Masahiro,Kiyama Yoshio,Kobayashi Naoki,Imamura Masahiro
- 日本造血細胞移植学会雑誌 2(2), 56-60, 2013
- … Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended for patients with chronic myeloid leukemia (CML) in the advanced phase, but the prognosis of patients who relapsed after allo-HSCT has been poor. …
- NAID 130003379440
- Identification of copy number alterations by array comparative genomic hybridization in patients with late chronic or accelerated phase chronic myeloid leukemia treated with imatinib mesylate
- NADARAJAN Veera S.,PHAN Chin-Lee,ANG Chow-Hiang,LIANG Kai-Ling,GAN Gin-Gin,BEE Ping-Chong,ZAKARIA Zubaidah
- International journal of hematology 93(4), 465-473, 2011-04-01
- NAID 10029534477
Related Links
- Treatment options for people with chronic myeloid leukemia (CML) depend on the phase of their disease (chronic, accelerated, or blast phase), their age, other prognostic factors, and the availability of a stem cell donor ...
- If you're in the later stages of chronic myelogenous leukemia (CML), there's a wide variety of ways you may feel. Some people have fever, lose their appetite, and drop a few pounds. But others don't have any symptoms. No matter ...
★リンクテーブル★
[★]
骨髄性白血病移行期、移行期骨髄性白血病
- 関
- accelerated phase myeloid leukemia、accelerated-phase chronic myeloid leukemia
[★]
移行期骨髄性白血病、骨髄性白血病移行期
- 関
- accelerated-phase chronic myeloid leukemia、aggressive-phase myeloid leukemia
[★]
- 英
- accelerated-phase chronic myeloid leukemia
- 関
- 移行期慢性骨髄性白血病、移行期骨髄性白血病
[★]
- 英
- accelerated-phase chronic myeloid leukemia
- 関
- 慢性骨髄性白血病移行期
[★]
- 関
- aspect、grade、period、phased、phasic、situation、stage、step、time
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- 関
- acceleration、expedite、facilitate、facilitation、further、hasten、promote、promotion
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- 関
- BM、bone marrow、myelo、myelocytic、myelogenous
[★]
- 関
- accelerating、acceleratingly、acceleratory、facilitatory、promotional
[★]
- 関
- chronically、chronicity