WordNet
- a nuclear reaction in which nuclei combine to form more massive nuclei with the simultaneous release of energy (同)nuclear_fusion, nuclear fusion reaction
- the merging of adjacent sounds or syllables or words
- correction of an unstable part of the spine by joining two or more vertebrae; usually done surgically but sometimes done by traction or immobilization (同)spinal_fusion
- the act of fusing (or melting) together
- an occurrence that involves the production of a union (同)merger, unification
- the combining of images from the two eyes to form a single visual percept (同)optical fusion
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- a substance that retards or stops an activity
- the 8th letter of the Roman alphabet (同)h
- infection by the human immunodeficiency virus
PrepTutorEJDIC
- 〈U〉(金属などが)溶けること,融解,融合《+『of』+『名』》 / 〈C〉融合物 / 〈C〉(政党・党派などの)連合,合同;(民族などの)融合《+『of』+『名』》 / 〈U〉〈C〉核融合(nuclear fusion)
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 抑制する人(物) / 化学反応抑制剤
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
UpToDate Contents
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- 1. HIV感染症の治療に用いる抗レトロウイルス薬の概要 overview of antiretroviral agents used to treat hiv
- 2. HIV-2感染の治療 treatment of hiv 2 infection
- 3. HIV療法に失敗した治療歴のあるHIV感染患者のための抗レトロウイルス療法の選択 selecting an antiretroviral regimen for treatment experienced hiv infected patients who are failing therapy
- 4. 未治療HIV感染患者のための抗レトロウイルス療法の選択 selecting antiretroviral regimens for the treatment naive hiv infected patient
- 5. HIV薬剤耐性検査の解釈についての手引 primer on interpretation of hiv drug resistance testing
English Journal
- Development of HIV-1 Fusion Inhibitors Targeting gp41.
- Lu K, Asyifah MR, Shao F, Zhang D1.
- Current medicinal chemistry.Curr Med Chem.2014 Jun;21(17):1976-96.
- The HIV-1 envelope protein glycoprotein 41 (gp41) is crucial in the HIV-1 infection process, therefore gp41 has emerged as an attractive target for drug design against AIDS. During the past few decades, tremendous efforts have been made on developing inhibitors that can prevent the HIV-1 entry proce
- PMID 24350848
- Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.
- Wang C1, Shi W1, Cai L1, Lu L2, Yu F3, Wang Q2, Jiang X1, Xu X1, Wang K1, Xu L1, Jiang S4, Liu K5.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2014 Jun;69(6):1537-45. doi: 10.1093/jac/dku010. Epub 2014 Feb 4.
- OBJECTIVES: To develop new HIV-1 fusion inhibitors with improved antiviral activities and resistance profiles, we designed two categories of artificial peptides, each containing four heptad repeats (m4HR) conjugated with a pocket-specific small molecule (pssm) or pssm and cholesterol (chol), designa
- PMID 24500189
- Inhibition of arenavirus infection by a glycoprotein-derived peptide with a novel mechanism.
- Spence JS1, Melnik LI1, Badani H2, Wimley WC2, Garry RF3.
- Journal of virology.J Virol.2014 May 21. pii: JVI.01133-14. [Epub ahead of print]
- The family Arenaviridae includes a number of viruses of public health importance, such as the Category A hemorrhagic fever viruses Lassa, Junin, Machupo, Guanarito, and Sabia. Current chemotherapy for arenavirus infection is limited to the nucleoside analogue ribavirin, which is characterized by con
- PMID 24850726
Japanese Journal
- インテグラーゼ阻害薬,ケモカインレセプター阻害薬、融合阻害薬 (特集 HIV/AIDS--最新の治療研究の進歩) -- (抗HIV薬・ワクチン研究の進歩)
- 潟永 博之
- 日本臨床 68(3), 520-524, 2010-03
- NAID 40016975407
- Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants
- Oishi Shinya,Watanabe Kentaro,Ito Saori,Tanaka Michinori,Nishikawa Hiroki,Ohno Hiroaki,Shimane Kazuki,Izumi Kazuki,Sakagami Yasuko,Kodama Eiichi N.,Matsuoka Masao,Asai Akira,Fujii Nobutaka
- MedChemComm 1(4), 276-281, 2010
- … Enfuvirtide is the first approved membrane fusion inhibitor against HIV-1. … Based on the high affinity of synthetic HIV-1 gp41 C-terminal heptad repeat (C-HR) peptides to the counterpart trimeric N-terminal heptad repeat (N-HR) coiled-coil structure, a novel screening approach has been established to facilitate the identification of potent fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. …
- NAID 120002484932
Related Links
- One of many classes of HIV medications, an HIV fusion inhibitor acts on the virus before it eters the CD4 cell. ... Definition: A class of antiretroviral agent that binds to the envelope protein of the human CD4 and blocks ...
- One such example is enfuvirtide, the first available and only licensed HIV fusion inhibitor. HIV fusion The scientific investigation of the life cycle of HIV has been an area of intense research since the first description of the virus in ). ...
Related Pictures
★リンクテーブル★
| リンク元 | 「HIV融合阻害剤」「HIV融合阻害薬」 |
| 関連記事 | 「inhibit」「inhibitor」「fusion」「HIV」「H」 |
「HIV融合阻害剤」
「HIV融合阻害薬」
「inhibit」
- v.
- 抑制する、阻害する、阻止する
- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
「inhibitor」
- n.
「fusion」
- n.
「HIV」
[★] human immunodeficiency virus HIVウイルス ヒト免疫不全ウイルス
「H」