WordNet

of or related to the anus; "anal thermometer"
a stage in psychosexual development when the childs interest is concentrated on the anal region; fixation at this stage is said to result in orderliness, meanness, stubbornness, compulsiveness, etc. (同)anal retentive

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肛門(こうもん)(anus)の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/07 19:17:55」(JST)

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A gonadotropin-releasing hormone analogue (GnRH analogue or analog), also known as a luteinizing hormone releasing hormone agonist (LHRH agonist) or LHRH analogue is a synthetic peptide drug modeled after the human hypothalamic gonadotropin-releasing hormone (GnRH). A GnRH analogue is designed to interact with the GnRH receptor and modify the release of pituitary gonadotropins FSH and LH for therapeutic purposes. Shortly after the discovery of GnRH by Nobel laureates Guillemin and Schally researchers tried to modify the GnRH decapeptide with the intent to synthesize stimulating and blocking variants.

Two types of analogues have to be distinguished:

Agonists

A gonadotropin-releasing hormone agonist (GnRH agonist) is an analogue that activates the GnRH receptor resulting in increased secretion of FSH and LH. Initially it was thought that agonists could be used as potent and prolonged stimulators of pituitary gonadotropin release, but it was soon recognized that agonists, after their initial stimulating action – termed a “flare” effect - eventually caused a paradoxical and sustained drop in gonadotropin secretion. This second effect was termed “downregulation” and can be observed after about 10 days. While this phase is reversible upon stopping the medication, it can be maintained when GnRH agonists use is continued for a long time.

Antagonists

A gonadotropin-releasing hormone antagonist (GnRH antagonist) is an analogue that blocks the GnRH receptor resulting in an immediate drop in gonadotropin (FSH, LH) secretion. The GnRH antagonist is primarily used in IVF treatments to block natural ovulation.

All GnRH analogues are contraindicated in pregnancy (pregnancy category X).

References

Speroff L, Glass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility. Fifth Edition. Willimas 7 Wilkins, Baltimore. 1994. Pages 160-161.
History of GnRH agonist and antagonist development

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1. 子宮内膜症の長期治療を目的としたゴナドトロピン放出ホルモンアゴニスト gonadotropin releasing hormone agonists for long term treatment of endometriosis
2. 去勢感受性前立腺癌の初期全身療法 initial systemic therapy for castration sensitive prostate cancer
3. アンドロゲン過剰症および男性型多毛症治療におけるGnRHアゴニストの使用 use of gnrh agonists in the treatment of hyperandrogenism and hirsutism
4. 子宮内膜症の治療の概要 overview of the treatment of endometriosis
5. 思春期早発症の治療 treatment of precocious puberty

English Journal

Expression of hypoxia-inducible factors and vascular endothelial growth factor during pregnancy in the feline uterus.

Agaoglu OK1, Agaoglu AR2, Guzeloglu A3, Kurar E3, Kayis SA4, Ozmen O5, Schäfer-Somi S6, Aslan S7.
Theriogenology.Theriogenology.2015 Jul 1;84(1):24-33. doi: 10.1016/j.theriogenology.2015.02.009. Epub 2015 Feb 16.
Hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) have critical roles during the development of the fetomaternal unit. The HIFs regulate placentation and vascularization by stimulation of VEGF gene expression. This study aimed to investigate the expression profiles of HI
PMID 25794839

Puberty suppression and executive functioning: An fMRI-study in adolescents with gender dysphoria.

Staphorsius AS1, Kreukels BP2, Cohen-Kettenis PT2, Veltman DJ3, Burke SM4, Schagen SE5, Wouters FM6, Delemarre-van de Waal HA7, Bakker J8.
Psychoneuroendocrinology.Psychoneuroendocrinology.2015 Jun;56:190-9. doi: 10.1016/j.psyneuen.2015.03.007. Epub 2015 Mar 11.
Adolescents with gender dysphoria (GD) may be treated with gonadotropin releasing hormone analogs (GnRHa) to suppress puberty and, thus, the development of (unwanted) secondary sex characteristics. Since adolescence marks an important period for the development of executive functioning (EF), we dete
PMID 25837854

Efficacy and Safety of Domestic Leuprorelin in Girls with Idiopathic Central Precocious Puberty: A Multicenter, Randomized, Parallel, Controlled Trial.

Li WJ, Gong CX1, Guo MJ, Xing J, Li T, Song WH, Luo XP, Wu D, Liang JP, Cao BY, Gu Y, Su C, Liang XJ, Liu M, Wang R, Li FT.
Chinese medical journal.Chin Med J (Engl).2015 20th May;128(10):1314-1320. doi: 10.4103/0366-6999.156773.
BACKGROUND: In central precocious puberty (CPP), the pulse secretion and release of gonadotropin-releasing hormone (GnRH) are increased due to early activation of the hypothalamic-pituitary-gonadal axis, resulting in developmental abnormalities with gonadal development and appearance of secondary se
PMID 25963350

Japanese Journal

Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.

Misu Ryosuke,Noguchi Taro,Ohno Hiroaki,Oishi Shinya,Fujii Nobutaka
Bioorganic & medicinal chemistry 21(8), 2413-2417, 2013-04-15
… Neurokinin B (NKB) is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R). … The corresponding substitutions to NKB provided an NK3R selective analog. …
NAID 120005244454

Differential Effects of Continuous Exposure to the Investigational Metastin/Kisspeptin Analog TAK-683 on Pulsatile and Surge Mode Secretion of Luteinizing Hormone in Ovariectomized Goats

, , [他], , , , , , ,
Journal of Reproduction and Development 59(6), 563-568, 2013
… The aim of the present study was to determine if the estradiol-induced luteinizing hormone (LH) surge is influenced by the constant exposure to TAK-683, an investigational metastin/kisspeptin analog, that had been established to depress the pulsatile gonadotropin-releasing hormone (GnRH) and LH secretion in goats. …
NAID 130003361063

GnRHアナログによるうつ病の1例

栗田郁,宮坂尚幸,吉田卓功 [他],羅ことい,鬼塚真由美,田丸陽子,塚田貴史,後藤亮子,市川麻以子,遠藤誠一,坂本雅恵,島袋剛二
日本農村医学会雑誌 60(5), 627-630, 2012-01-31
NAID 10030401001

「性腺刺激ホルモン放出ホルモンアナログ化合物」

　　[★]

英: gonadotropin-releasing hormone analog GnRHa
同: GnRHアナログ GnRH analog
関: 性腺刺激ホルモン放出ホルモン誘導体、性腺刺激ホルモン放出ホルモン拮抗物

「analog」

　　[★]

n.

類似体、類似物、類縁体、アナログ、類似化合物、誘導体

関: analogue、derivate、derivative、relative

linux

analogのオプション

1	YEARLY	年別レポート
Q	QUARTERLY	4半期別レポート
m	MONTHLY	月別レポート
W	WEEKLY	週別レポート	ON
D	DAILYREP	日別レポート	ON
d	DAILYSUM	曜日別集計
H	HOURLYREP	時間別レポート	ON
h	HOURLYSUM	時間別集計	ON
w	WEEKHOUR	曜日別時間集計
4	QUARTERREP	15分間隔レポート	ON
6	QUARTERSUM	15分間隔集計	ON
5	FIVEREP	5分間隔レポート
7	FIVESUM	5分間隔集計
S	HOST	ホストレポート	ON
l	REDIRHOST	ホストリダイレクションレポート	ON
L	FAILHOST	ホスト不成功レポート	ON
Z	ORGANISATION	組織レポート	ON
o	DOMAIN	ドメインレポート	ON
r	REQUEST	リクエストレポート	ON
i	DIRECTORY	ディレクトリレポート	ON
t	FILETYPE	ファイル種類別レポート	ON
z	SIZE	ファイルサイズレポート	ON
P	PROCTIME	処理時間レポート	ON
E	REDIR	リダイレクトレポート	ON
I	FAILURE	不成功レポート	ON
f	REFERRER	リンク元レポート	ON
s	REFSITE	リンク元サイトレポート	ON
N	SEARCHQUERY	検索語句レポート	ON
n	SEARCHWORD	検索語レポート	ON
Y	INTSEARCHQUERY	内部検索語句レポート	ON
y	INTSEARCHWORD	内部検索単語レポート	ON
k	REDIRREF	リダイレクトされたリンク元URLレポート	ON
K	FAILREF	不成功リンク元レポート	ON
B	FULLBROWSER	ブラウザーレポート	ON
b	BROWSER	ブラウザーの概要	ON
p	OSREP	OSレポート	ON
v	VHOST	仮想ホストレポート	ON
R	REDIRVHOST	仮想ホストリダイレクションレポート	ON
M	FAILVHOST	仮想ホスト不成功レポート	ON
u	USER	ユーザレポート	ON
j	REDIRUSER	ユーザリダイレクションレポート	ON
J	FAILUSER	不成功ユーザレポート	ON
c	STATUS	状態コードレポート	ON