Fcε receptor I

FcεRI

同

FcεRI

WordNet

1. the 9th letter of the Roman alphabet (同)i
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
3. the 6th letter of the Roman alphabet (同)f

PrepTutorEJDIC

1. 『私は』私が
2. iodineの化学記号
3. =sense organ / 受信装置

UpToDate Contents

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• 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 2. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 3. T細胞受容体の遺伝学 t cell receptor genetics
• 4. T細胞受容体シグナル伝達 t cell receptor signaling
• 5. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention

Japanese Journal

• Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

• KARASAWA Koji,OTANI Hajime
• Journal of Nutritional Science and Vitaminology 58(4), 272-277, 2012
• … The serum total and mite antigen-specific immunoglobulin (Ig) E levels, and the number of spleen interleukin-4+CD4+, IgE+B220+ and FcεRIα+CD117+ cells was significantly lower in mice given the date extract-added diet than in those given the control diet. … Chlorogenic acid, pelargonin and ferulic acid significantly reduced the number of IgE+B220+ cells, while chlorogenic acid and pelargonin significantly decreased the number of FcεRIα+CD117+ cells in mouse spleen cell cultures. …
• NAID 130002103018

• Measurement for Canine IgE Using Canine Recombinant High Affinity IgE Receptor α Chain (FcεRIα)

• TSUKUI Toshihiro,SAKAGUCHI Masahiro,KURATA Keigo [他],MAEDA Sadatoshi,OHMORI Keitaro,MASUDA Kenichi,TSUJIMOTO Hajime,IWABUCHI Shigehiro
• Journal of Veterinary Medical Science 74(7), 851-856, 2012
• … To detect allergen-specific IgE in dogs with allergic diseases, we developed a recombinant canine high affinity IgE receptor α chain (FcεRIα)-based IgE detection system. … Using the recombinant protein of canine FcεRIα expressed by an Escherichia coli expression system, we could detect house dust mite (Dermatophagoides farinae) allergen-specific IgE in sera from dogs naturally and experimentally sensitized to this allergen with ELISA and western blotting. …
• NAID 130001879766

• Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells

• Li Xian,Lu Yue,Yang Ju Hye [他],Jin Ye,Hwang Seung-Lark,Chang Hyeun Wook
• Biological and Pharmaceutical Bulletin 35(2), 216-222, 2012
• … The high-affinity receptor for immunoglobulin E (IgE) (FcεRI)-mediated activation of mast cells plays an important role in various allergic diseases. …
• NAID 130001872296

Related Links

• High affinity immunoglobulin gamma Fc receptor I Antibodies ...

Mouse Anti-High affinity immunoglobulin gamma Fc receptor I antibody, Monoclonal[10.1] 100 ug Hu, Pr FA, FACS, ICC, IHC-F, IHC-P, IP, WB Datasheet 1F-644-T100 Mouse Anti-High affinity immunoglobulin gamma Fc receptor ...

• High affinity immunoglobulin gamma Fc receptor I Antibodies ...

LS-C112618 Mouse Anti-High affinity immunoglobulin gamma Fc receptor I antibody, Monoclonal[10.1] 100 ug Hu, Pr FACS, ICC, IHC-F, IHC-F, IP, WB Datasheet LS-C21927 Mouse Anti-High affinity immunoglobulin gamma Fc ...

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★リンクテーブル★

リンク元	「FcεRI」
関連記事	「I」「Fc」「Id」「F」

「FcεRI」

　　[★]

同

Fcε receptor I

関

FcεRII

• I型アレルキーに関与

構造

• 3量体4分子からなる
• αx1：
• βx1：4回膜貫通
• γx2：シグナル伝達に関わる。TCRのシグナル伝達サブユニットであるζに似ており、Fc受容体のαサブユニットと非共役的に結合している。

発現細胞

• 肥満細胞、好酸球(not constitutive but inducible)、好塩基球 (IMM.410)

(免疫学 080526)

FcεRI	肥満細胞	I型アレルギーに関与
	好酸球
FcεRII	T細胞	花粉のシーズンのアトピーにおいて1%のT細胞でFcεRII(+)となる
	B細胞	花粉のシーズンのアトピーにおいて30%のB細胞でFcεRII(+)となる
	単球	ある20%のアレルギー性疾患で2%の単球でFcεRII(+)となる
	肺胞マクロファージ	IgEを介した酵素放出
	好酸球	寄生虫に対するIgEを介したエフェクター細胞
	血小板

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「Fc」

　　[★]

• 免疫グロブリン結晶化可能断片

関

Fc fragment、immunoglobulin Fc fragment

「Id」

　　[★]

• イディオタイプ idiotype idiotypic
• inhibitor of DNA binding

「F」

　　[★] フェニルアラニン phenylalanine