WordNet

a piece broken off or cut off of something else; "a fragment of rock"
an incomplete piece; "fragments of a play"
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin
the 6th letter of the Roman alphabet (同)f

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(…の)『破片』,断片《+『of』+『名』》 / (特に詩文などの)未完の部分,断章《+『of』+『名』》 / ばらばらになる,砕ける / …‘を'ばらばらに壊す

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1. 免疫グロブリンの構造 structure of immunoglobulins
2. 免疫グロブリンの機能および臨床応用 function and clinical applications of immunoglobulins
3. 血液疾患における免疫グロブリンの静脈内投与 intravenous immune globulin in hematologic disorders
4. 体液性免疫応答 the humoral immune response
5. 腫瘍壊死因子受容体-1関連周期性発熱症候群（TRAPS） tumor necrosis factor receptor 1 associated periodic syndrome traps

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

Gurbaxani B, Dostalek M, Gardner I.SourceChronic Viral Diseases Branch, Division of High-Consequence Pathogens and Pathology, National Centre for Emerging and Zoonotic Infectious Diseases, Centres for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: brian.gurbaxani@cdc.hhs.gov.
Molecular immunology.Mol Immunol.2013 Dec 31;56(4):660-74. doi: 10.1016/j.molimm.2013.05.008. Epub 2013 Aug 2.
F.W.R. Brambell deduced the existence of a protective receptor for IgG, the neonatal Fc receptor (FcRn), long before its discovery in the early to mid-1990s. With the coincident, explosive development of IgG-based drugs, FcRn became a popular target for tuning the pharmacokinetics of monoclonal anti
PMID 23917469

Teplyakov A, Zhao Y, Malia TJ, Obmolova G, Gilliland GL.SourceBiologics Research, Biotechnology Center of Excellence, Janssen R&D LLC, Spring House, PA 19477, United States. ateplyak@its.jnj.com
Molecular immunology.Mol Immunol.2013 Nov;56(1-2):131-9. doi: 10.1016/j.molimm.2013.03.018. Epub 2013 Apr 28.
The analyses of two human IgG2 Fc structures, determined in different crystal forms, and the comparison with IgG1 Fc structures reveals molecular features that are involved in accommodating and stabilizing structural conformations. In the IgG2 Fc structures relative positions of the CH2 domains with
PMID 23628091

Immunoglobulin-mediated neuro-cognitive impairment: new data and a comprehensive review.

Menachem A, Chapman J, Deri Y, Pick CG, Katzav A.SourceDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 66978, Israel.
Clinical reviews in allergy & immunology.Clin Rev Allergy Immunol.2013 Oct;45(2):248-55. doi: 10.1007/s12016-013-8357-z.
Excessive influx of immunoglobulin (IgG) into the brain has been reported to induce central nervous system (CNS) dysfunction. Depressed patients may exhibit immune activation manifested by elevated inflammatory markers and pro-inflammatory cytokines. The brain and especially the limbic system contai
PMID 23325332

Cloning of a soluble isoform of the SgIGSF adhesion molecule that binds the extracellular domain of the membrane-bound isoform.

Koma Yu-ichiro,Ito Akihiko,Wakayama Tomohiko,Watabe Kenji,Okada Morihito,Tsubota Noriaki,Iseki Shoichi,Kitamura Yukihiko
Oncogene 23(33), 5687-5692, 2004-07
… SgIGSF (spermatogenic immunoglobulin superfamily) is a recently identified intercellular adhesion molecule of the immunoglobulin superfamily. … We constructed a plasmid expressing sSgIGSF fused to the human IgG Fc fragment at its C-terminus (sSgIGSF-Fc), and transfected it into COS-7 cells. … Addition of sSgIGSF-Fc inhibited the aggregation of L cells overexpressing mSgIGSF in a dose-dependent manner. …
NAID 120001597078

加藤晃一
藥學雜誌 121(5), 345-354, 2001-05-01
… Fcγ Receptors(FcγR) are membrane glycoproteins that bind the Fc portion of immunoglobulin G(IgG). … The cross linking of FcγR-bound IgG by multivalent antigens allows clustering of the FcγR and initiates a variety of effector mechanisms which play a key role in immune defenses against pathogens. …
NAID 110003648523