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- 1. 選択的IgE欠損症 selective ige deficiency
- 2. T細胞受容体の遺伝学 t cell receptor genetics
- 3. 小細胞肺癌の治療に対する実験的アプローチ experimental approaches to treatment for small cell lung cancer
- 4. 免疫グロブリン静脈内投与（IVIG）療法の概要 overview of intravenous immune globulin ivig therapy
- 5. ケトーシス傾向のある糖尿病症候群 syndromes of ketosis prone diabetes mellitus
English Journal
- Manipulating mIgD-expressing B cells with anti-migis-δ monoclonal antibodies.
- Chen NY, Hung AF, Lin CJ, Chen JB, Chu HM, Yu HM, Chang HY, Chang TW.SourceGenomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
- Molecular immunology.Mol Immunol.2013 Mar;53(3):187-97. doi: 10.1016/j.molimm.2012.08.010. Epub 2012 Sep 1.
- Surface IgD and IgM doubly positive cells comprise the major population of B cells in the human immune system. The heavy chain of membrane-bound IgD (mδ) differs from that of IgD (δ) in that mδ contains a C-terminal membrane-anchor peptide. Our group previously proposed that the N-terminal extrac
- PMID 22944457
- Successes, failures and new perspectives of idiotypic vaccination for B-cell non-Hodgkin lymphomas.
- Muraro E, Martorelli D, Dolcetti R.SourceCancer Bio-Immunotherapy Unit; CRO-IRCCS; National Cancer Institute; Aviano, Italy.
- Human vaccines & immunotherapeutics.Hum Vaccin Immunother.2013 Feb 13;9(6). [Epub ahead of print]
- The idiotype of B-cell non-Hodgkin lymphomas has been intensively investigated for its proven immunogenicity as a promising cancer vaccine. Indeed, available data clearly indicate that these vaccines are able to induce tumor-specific immune responses and molecular remissions in patients with follicu
- PMID 23406835
- Anti-Idiotypic Monobodies Derived from a Fibronectin Scaffold.
- Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S.AbstractMimetics of conformational protein epitopes have broad applications, but have been difficult to identify using conventional peptide phage display. The tenth type III domain of human fibronectin (FNfn10) has two extended, randomizable surface-exposed loops and might be more amenable to the identification of such mimetics. We therefore selected a library of FNfn10 clones, randomized in both loops (15 residues in all), for binding to monoclonal antibodies (MAb) that recognize the HIV-1 envelope glycoprotein. Anti-idiotypic monobodies (αIMs) mimicking both "linear" epitopes (2F5 and 4E10 MAbs) and conformational epitopes (b12 and VRC01 MAbs) were generated. αIMs selected against 2F5 and 4E10 frequently displayed sequence homology to the corresponding linear native epitopes. In the case of b12 and VRC01, we expected that the two constrained loop domains of FNfn10 would both contribute to complex conformational interactions with target antibodies. However, mutagenesis studies revealed differences from this simple model An αIM selected against b12 was found to bind its cognate antibody via only a few residues within the BC loop of FNfn10, with minimal contribution from the FG loop. Unexpectedly, this was sufficient to generate a protein that engaged its cognate antibody in a manner very similar to HIV-1 Env, and with a strong K(D) (43 nM). In contrast, an αIM selected against VRC01 engaged its cognate antibody in a manner that was dependent on both BC and FG loop sequences. Overall, these data suggest that the FNfn10 scaffold can be used to identify complex structures that mimic conformational protein epitopes. ααα
- Biochemistry.Biochemistry.2013 Feb 8. [Epub ahead of print]
- Mimetics of conformational protein epitopes have broad applications, but have been difficult to identify using conventional peptide phage display. The tenth type III domain of human fibronectin (FNfn10) has two extended, randomizable surface-exposed loops and might be more amenable to the identifica
- PMID 23394681
Japanese Journal
- 動的免疫ネットワークの多重化による創発的集団の形成(社会システムと情報技術)
- 山保 太力,松田 聖
- 電子情報通信学会技術研究報告. AI, 人工知能と知識処理 111(474), 7-12, 2012-03-06
- 人間の行動は複数の誘因の相互作用により決定されるという仮定の下,行動間の調停機構として生体の免疫系を対応させた.その中で,イディオタイプネットワークの持つ創発的性質に着目し,抗体の生成・消滅に伴った再構成や刺激・抑制の流れに変移のある動的なネットワークを構築し,エージェント群に適用させた.また,リズムを通じたユーザとの対話を抗原,それに対する反応を抗体とみなし,動的イディオタイプネットワークのエン …
- NAID 110009546056
- Different buffer effects in selecting HM-1 killer toxin single-chain fragment variable anti-idiotypic antibodies
- Krishnaswamy Senthilkumar,Kabir M. Enamul,Miyamoto Masahiko [他],FURUICHI Yasuhiro,KOMIYAMA Tadazumi
- The journal of biochemistry 147(5), 723-733, 2010-05-01
- NAID 10027875919
- Vaccination with autoreactive CD4+Th1 clones in lupus-prone MRL/Mp-Faslpr/lpr mice
- Fujii Takao,Okada Masato,Fujita Yoshimasa,Sato Takeshi,Tanaka Masao,Usui Takashi,Umehara Hisanori,Mimori Tsuneyo
- Journal of Autoimmunity 33(2), 125-134, 2009-09
- … Anti-idiotypic humoral and T cell responses against the transferred autoreactive Th1 clones were determined in parallel. … Anti-idiotypic Abs recognizing a 12 amino acid sequence of clone dna51 T cell receptor Vβ8.3-complementarity-determining region (CDR) 3 were detected in the MRL/lpr mice that received i-dna51 or s-dna51 cells. …
- NAID 120001596907
Related Links
- In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of ...
- Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody. ... If such is the case, the anti- idiotypic antibodies will be able to bind to the B lymphocyte receptor for the original ...
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