- 関
- CSF-1 receptor、M-CSF receptor
WordNet
- a geographical area politically controlled by a distant country (同)dependency
- a body of people who settle far from home but maintain ties with their homeland; inhabitants remain nationals of their home state but are not literally under the home states system of government; "the American colony in Paris" (同)settlement
- (microbiology) a group of organisms grown from a single parent cell
- a group of organisms of the same type living or growing together
- a place where a group of people with the same interest or occupation are concentrated; "a nudist colony"; "an artists colony"
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the basic unit of money in Costa Rica; equal to 100 centimos (同)Costa Rican colon
- the basic unit of money in El Salvador; equal to 100 centavos (同)El Salvadoran colon
- a punctuation mark (:) used after a word introducing a series or an example or an explanation (or after the salutation of a business letter)
- the part of the large intestine between the cecum and the rectum; it extracts moisture from food residues before they are excreted
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『植民地』 / 植民団,居留民;(外国人の)集団居留地 / (同ど人種・宗教・職業などの人たちが住む)『集団』,部落 / (動物・鳥・虫などの)集団;(生物の)群体,群落《+『of』+『名』》 / 《the Colonies》アメリカ合衆国を形成した13州のイギリス植民地
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- コロン(:)(句読点の一種で,文中においてセミコロン以上を分離を示すほか,対照,例証,引用文などを示すのに用いる)
- (大腸の)結腸[部]
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/26 00:24:18」(JST)
[Wiki en表示]
| Colony stimulating factor 1 receptor |
Rendering based on PDB 2I0V. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7
|
|
|
| Identifiers |
| Symbols |
CSF1R; C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R |
| External IDs |
OMIM: 164770 MGI: 1339758 HomoloGene: 3817 ChEMBL: 1844 GeneCards: CSF1R Gene |
| EC number |
2.7.10.1 |
| Gene Ontology |
| Molecular function |
• macrophage colony-stimulating factor receptor activity
• ATP binding
• cytokine binding
• protein homodimerization activity
|
| Cellular component |
• plasma membrane
• integral to plasma membrane
• cell surface
• receptor complex
|
| Biological process |
• positive regulation of protein phosphorylation
• inflammatory response
• signal transduction
• transmembrane receptor protein tyrosine kinase signaling pathway
• multicellular organismal development
• cell proliferation
• positive regulation of cell proliferation
• regulation of cell shape
• peptidyl-tyrosine phosphorylation
• cytokine-mediated signaling pathway
• hemopoiesis
• monocyte differentiation
• macrophage differentiation
• osteoclast differentiation
• positive regulation of cell migration
• ruffle organization
• cellular response to macrophage colony-stimulating factor stimulus
• macrophage colony-stimulating factor signaling pathway
• positive regulation of tyrosine phosphorylation of Stat3 protein
• innate immune response
• regulation of bone resorption
• cell-cell junction maintenance
• phosphatidylinositol metabolic process
• protein autophosphorylation
• phosphatidylinositol-mediated signaling
• mammary gland duct morphogenesis
• positive regulation of protein tyrosine kinase activity
• positive regulation of ERK1 and ERK2 cascade
• cellular response to cytokine stimulus
• positive regulation of protein serine/threonine kinase activity
• positive regulation of chemokine secretion
• positive regulation of cell motility
• regulation of actin cytoskeleton reorganization
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
1436 |
12978 |
|
| Ensembl |
ENSG00000182578 |
ENSMUSG00000024621 |
|
| UniProt |
P07333 |
P09581 |
|
| RefSeq (mRNA) |
NM_005211 |
NM_001037859 |
|
| RefSeq (protein) |
NP_005202 |
NP_001032948 |
|
| Location (UCSC) |
Chr 5:
149.43 – 149.49 Mb |
Chr 18:
61.11 – 61.13 Mb |
|
| PubMed search |
[1] |
[2] |
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Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene.[1][2] It is a receptor for a cytokine called colony stimulating factor 1.
Contents
- 1 Genomics
- 2 Function
- 3 Clinical significance
- 4 Interactions
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Genomics[edit]
The gene is located on long arm of chromosome 5 (5q32) on the Crick (minus) strand. It is 60.002 kilobases in length. The encoded protein has 972 amino acids and a predicted molecular weight of 107.984 kiloDaltons. The first intron of the CSFR1 gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene, oriented in the opposite direction to the CSFR1 gene.[1]
Function[edit]
The encoded protein is a single pass type I membrane protein and acts as the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Clinical significance[edit]
Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.[3] Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active.[4] Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.[5][6][7] Mutations in the tyrosine kinase domain have been associated with hereditary diffuse leukoencephalopathy with spheroids.
Interactions[edit]
Colony stimulating factor 1 receptor has been shown to interact with:
- Cbl gene,[8]
- FYN,[9]
- Grb2,[10]
- Suppressor of cytokine signaling 1,[11] This receptor is also linked with the cells of MPS.
See also[edit]
- Cluster of differentiation
References[edit]
- ^ a b EntrezGene 1436
- ^ Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15→q23". Cytogenet. Cell Genet. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- ^ Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA (February 1990). "FMS mutations in myelodysplastic, leukemic, and normal subjects". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1377–80. doi:10.1073/pnas.87.4.1377. JSTOR 2353838. PMC 53478. PMID 2406720.
- ^ Mitrasinovic OM, Grattan A, Robinson CC, Lapustea NB, Poon C, Ryan H, Phong C, Murphy GM (April 2005). "Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system". J. Neurosci. 25 (17): 4442–51. doi:10.1523/JNEUROSCI.0514-05.2005. PMID 15858070.
- ^ Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE (January 2008). "Circulating colony stimulating factor-1 and breast cancer risk". Cancer Res. 68 (1): 18–21. doi:10.1158/0008-5472.CAN-07-3234. PMC 2821592. PMID 18172291.
- ^ Pollard JW, Hennighausen L (September 1994). "Colony stimulating factor 1 is required for mammary gland development during pregnancy". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9312–6. doi:10.1073/pnas.91.20.9312. PMC 44802. PMID 7937762.
- ^ Sapi E (January 2004). "The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update". Exp. Biol. Med. (Maywood) 229 (1): 1–11. PMID 14709771.
- ^ Mancini A, Koch A, Wilms R, Tamura T (April 2002). "c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms". J. Biol. Chem. 277 (17): 14635–40. doi:10.1074/jbc.M109214200. PMID 11847211.
- ^ Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF (March 1993). "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor". EMBO J. 12 (3): 943–50. PMC 413295. PMID 7681396.
- ^ Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T (September 1997). "Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene 15 (13): 1565–72. doi:10.1038/sj.onc.1201518. PMID 9380408.
- ^ Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560.
Further reading[edit]
- Rettenmier CW, Roussel MF, Sherr CJ (1988). "The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand". J. Cell Sci. Suppl. 9: 27–44. PMID 2978516.
- Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). "Biology and action of colony--stimulating factor-1". Mol. Reprod. Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
- Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. 288 ( Pt 2): 395–405. PMC 1132024. PMID 1334406.
- Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi AY, Wang LM, Oscier DG, Buckle VJ, Wainscoat JS (July 1991). "Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6176–80. doi:10.1073/pnas.88.14.6176. PMC 52045. PMID 1829836.
- Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ (September 1991). "Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling". Nature 353 (6342): 361–3. doi:10.1038/353361a0. PMID 1833648.
- Reedijk M, Liu XQ, Pawson T (November 1990). "Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor". Mol. Cell. Biol. 10 (11): 5601–8. PMC 361316. PMID 2172781.
- Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (July 1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1". Cell 41 (3): 665–76. doi:10.1016/S0092-8674(85)80047-7. PMID 2408759.
- Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A (1986). "Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus". Nature 320 (6059): 277–80. doi:10.1038/320277a0. PMID 2421165.
- Hampe A, Shamoon BM, Gobet M, Sherr CJ, Galibert F (1989). "Nucleotide sequence and structural organization of the human FMS proto-oncogene". Oncogene Res. 4 (1): 9–17. PMID 2524025.
- Visvader J, Verma IM (March 1989). "Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes". Mol. Cell. Biol. 9 (3): 1336–41. PMC 362728. PMID 2524648.
- Roberts WM, Look AT, Roussel MF, Sherr CJ (November 1988). "Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes". Cell 55 (4): 655–61. doi:10.1016/0092-8674(88)90224-3. PMID 2846185.
- Xu DQ, Guilhot S, Galibert F (May 1985). "Restriction fragment length polymorphism of the human c-fms gene". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2862–5. doi:10.1073/pnas.82.9.2862. JSTOR 25278. PMC 397666. PMID 2986142.
- Sherr CJ, Rettenmier CW (1986). "The fms gene and the CSF-1 receptor". Cancer Surv. 5 (2): 221–32. PMID 3022923.
- Le Beau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (February 1986). "Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders". Science 231 (4741): 984–7. doi:10.1126/science.3484837. PMID 3484837.
- Wheeler EF, Roussel MF, Hampe A, Walker MH, Fried VA, Look AT, Rettenmier CW, Sherr CJ (August 1986). "The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences". J. Virol. 59 (2): 224–33. PMC 253070. PMID 3525854.
- Verbeek JS, Roebroek AJ, van den Ouweland AM, Bloemers HP, Van de Ven WJ (February 1985). "Human c-fms proto-oncogene: comparative analysis with an abnormal allele". Mol. Cell. Biol. 5 (2): 422–6. PMC 366728. PMID 3974576.
- Lee AW, Nienhuis AW (September 1990). "Mechanism of kinase activation in the receptor for colony-stimulating factor 1". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7270–4. doi:10.1073/pnas.87.18.7270. PMC 54725. PMID 2169623.
External links[edit]
- CSF1R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Protein kinases: tyrosine kinases (EC 2.7.10)
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Receptor tyrosine kinases (EC 2.7.10.1)
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| Growth factor receptors |
| EGF receptor family |
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| Insulin receptor family |
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| PDGF receptor family |
- CSF1R
- FLT3
- KIT
- PDGFR (PDGFRA
- PDGFRB)
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| FGF receptor family |
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| VEGF receptors family |
- VEGFR1
- VEGFR2
- VEGFR3
- VEGFR4
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| HGF receptor family |
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| Trk receptor family |
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| EPH receptor family |
- EPHA1
- EPHA2
- EPHA3
- EPHA4
- EPHA5
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB5
- EPHB6
- EPHX
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| LTK receptor family |
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| TIE receptor family |
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| ROR receptor family |
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| DDR receptor family |
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| PTK7 receptor family |
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| RYK receptor family |
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| MuSK receptor family |
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| ROS receptor family |
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| AATYK receptor family |
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| AXL receptor family |
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| RET receptor family |
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| uncatagorised |
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Non-receptor tyrosine kinases (EC 2.7.10.2)
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| ABL family |
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| ACK family |
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| CSK family |
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| FAK family |
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| FES family |
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| FRK family |
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| JAK family |
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| SRC-A family |
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| SRC-B family |
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| TEC family |
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| SYK family |
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Cytokine receptors
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Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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| Other |
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| TNF receptor |
| 1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
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| 11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
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| 21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
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| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
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| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
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| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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| Other |
- hormone receptor: GH
- prolactin
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| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
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| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
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| IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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| S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Fibroblasts Regulate Variable Aggressiveness of Syndromic Keratocystic and Non-syndromic Odontogenic Tumors.
- Hong YY1, Yu FY1, Qu JF1, Chen F2, Li TJ3.
- Journal of dental research.J Dent Res.2014 Sep;93(9):904-10. doi: 10.1177/0022034514542108. Epub 2014 Jun 27.
- Keratocystic odontogenic tumors (KCOTs) are jaw lesions that can be either sporadic or associated with nevoid basal cell carcinoma syndrome, which typically occurs as multiple, aggressive lesions that can lead to large areas of bone destruction and resorption and cause major impairment and even jaw
- PMID 24972872
- Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition.
- Payne TL1, Blackinton J2, Frisbee A3, Pickeral J4, Sawant S3, Vandergrift NA3, Freel SA5, Ferrari G5, Keene JD2, Tomaras GD6.
- Journal of virology.J Virol.2014 Sep 1;88(17):9514-28. doi: 10.1128/JVI.00802-14. Epub 2014 Jun 4.
- The ability of CD8(+) T cells to effectively limit HIV-1 replication and block HIV-1 acquisition is determined by the capacity to rapidly respond to HIV-1 antigens. Understanding both the functional properties and regulation of an effective CD8(+) response would enable better evaluation of T cell-di
- PMID 24899193
- Serum levels of M-CSF, RANKL and OPG in rats fed with Kashin-Beck disease-affected diet.
- Yan D, Pei F, Song Y.
- Journal of orthopaedic surgery and research.J Orthop Surg Res.2014 Aug 20;9(1):78. [Epub ahead of print]
- ObjectiveThere were no studies on the macrophage colony-stimulating factor (M-CSF), receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) in the pathogenesis of Kashin-Beck disease (KBD). The objective of the present study was to investigate the serum M-CSF, RANKL and OPG in rats
- PMID 25138985
Japanese Journal
- Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB.
- Tanaka Takeshi,Motoi Natsuki,Tsuchihashi Yoshiko,Tazawa Ryushi,Kaneko Chinatsu,Nei Takahito,Yamamoto Toshiyuki,Hayashi Tomayoshi,Tagawa Tsutomu,Nagayasu Takeshi,Kuribayashi Futoshi,Ariyoshi Koya,Nakata Koh,Morimoto Konosuke
- Journal of medical genetics 48(3), 205-209, 2011-03
- … Background Disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signalling causes pulmonary alveolar proteinosis (PAP). … Signalling and genetic defects in GM-CSF receptor were screened. …
- NAID 120002695916
- Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization
- Nakamoto Yasunari,Mizukoshi Eishiro,Kitahara Masaaki,Arihara Fumitaka,Sakai Yoshio,Kakinoki Kaheita,Fujita Yui,Marukawa Yohei,Arai Kuniaki,Yamashita Tatsuya,Mukaida Naofumi,Matsushima Kouji,Matsui Osamu,Kaneko Shuichi
- Clinical and Experimental Immunology 163(2), 165-177, 2011-02
- … DCs were derived from peripheral blood monocytes of patients with hepatitis C virus-related cirrhosis and HCC in the presence of interleukin (IL)-4 and granulocyte-macrophage colony-stimulating factor and stimulated with 0.1 KE/ml OK432 for 2 days. …
- NAID 120003141443
Related Links
- Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α-chain, the first member of the GM-CSF/interleukin (IL)–3/IL-5 family of hemopoietic cytokine ...
- 1. Blood. 2009 Aug 13;114(7):1289-98. doi: 10.1182/blood-2008-12-164004. Epub 2009 May 12. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.
★リンクテーブル★
[★]
- 英
- macrophage colony-stimulating factor receptor
- 関
- マクロファージコロニー刺激因子レセプター、CSF-1受容体、M-CSF受容体
[★]
CSF-1受容体、CSF-1レセプター
- 関
- M-CSF receptor、macrophage colony-stimulating factor receptor
[★]
M-CSF受容体、M-CSFレセプター
- 関
- CSF-1 receptor、macrophage colony-stimulating factor receptor
[★]
- 英
- macrophage colony-stimulating factor receptor
- 関
- マクロファージコロニー刺激因子受容体
[★]
- 関
- GM-CSF receptor
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
- 関
- exciting、irritant
[★]
[★]
結腸