WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
PrepTutorEJDIC
- carbonの化学記号
- certificate of deposit / (また『C.D.』)Civil Defense民間防衛
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/14 21:59:19」(JST)
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- 1. 小児における赤血球産生低下による貧血 anemia in children due to decreased red blood cell production
- 2. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
- 3. 鉄芽球性貧血の病態生理 pathophysiology of the sideroblastic anemias
- 4. 赤血球産生調節 regulation of erythropoiesis
- 5. 大赤血球症 macrocytosis
English Journal
- Human cytidine deaminase: A biochemical characterization of its naturally occurring variants.
- Micozzi D1, Carpi FM1, Pucciarelli S1, Polzonetti V1, Polidori P2, Vilar S3, Williams B4, Costanzi S5, Vincenzetti S6.Author information 1School of Biosciences and Biotechnology, University of Camerino, via Gentile III da Varano, 62032 Camerino, MC, Italy.2School of Pharmacy, University of Camerino, via circonvallazione 93/95, 62024 Matelica, MC, Italy.3Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.4Department of Chemistry, American University, Washington, DC 20016, USA.5Department of Chemistry, American University, Washington, DC 20016, USA. Electronic address: costanzi@american.edu.6School of Veterinary Medical Sciences, University of Camerino, via circonvallazione 93/95, 62024 Matelica, MC, Italy. Electronic address: silvia.vincenzetti@unicam.it.AbstractHuman cytidine deaminase is an enzyme of the pyrimidine salvage pathways that metabolizes several cytosine nucleoside analogs used as prodrugs in chemotherapy. We carried out a characterization of the cytidine deaminase 79A>C and 208G>A Single Nucleotide Polymorphisms, in order to highlight their functional role and provide data that could help fine-tune the chemotherapic use of cytosine nucleosides in patients carrying the above mentioned SNPs. The 79A>C SNP results in a K27Q change in a protein region not involved in the catalytic event. The 208G>A SNP produces an alanine to threonine substitution (A70T) within the conserved catalytic domain. Q27 variant is endowed with a greater catalytic efficiency toward the natural substrates and the antileukemic agent cytarabine (Ara-C), when compared to K27 variant. Molecular modeling, protein stability experiments and site-directed mutagenesis suggest that K27 variant may have an increased stability with respect to Q27 due to an ionic interaction between a lysine residue at position 27 and a glutamate residue at position 24. The T70 variant has a lower catalytic efficiency toward the analyzed substrates when compared to the A70 variant, suggesting that patients carrying the 208G>A SNP may have a greater exposure to cytosine based pro drugs, with possible toxicity consequences.
- International journal of biological macromolecules.Int J Biol Macromol.2014 Feb;63:64-74. doi: 10.1016/j.ijbiomac.2013.10.029. Epub 2013 Oct 29.
- Human cytidine deaminase is an enzyme of the pyrimidine salvage pathways that metabolizes several cytosine nucleoside analogs used as prodrugs in chemotherapy. We carried out a characterization of the cytidine deaminase 79A>C and 208G>A Single Nucleotide Polymorphisms, in order to highlight th
- PMID 24183806
- Toxoplasma gondii within skeletal muscle cells: a critical interplay for food-borne parasite transmission.
- Swierzy IJ1, Muhammad M1, Kroll J1, Abelmann A1, Tenter AM2, Lüder CG3.Author information 1Institute for Medical Microbiology, University Medical Center Göttingen, Georg-August-University, Kreuzbergring 57, 37075 Göttingen, Germany.2Institute for Parasitology, University of Veterinary Medicine Hanover, Bünteweg 17, 30559 Hanover, Germany.3Institute for Medical Microbiology, University Medical Center Göttingen, Georg-August-University, Kreuzbergring 57, 37075 Göttingen, Germany. Electronic address: clueder@gwdg.de.AbstractToxoplasma gondii infects virtually any nucleated cell type of warm-blooded animals and humans including skeletal muscle cells (SkMCs). Infection of SkMCs by T. gondii, differentiation from the highly replicative tachyzoites to dormant bradyzoites and tissue cyst formation are crucial for parasite persistence in muscle tissue. These processes are also prerequisites for one of the major routes of transmission to humans via undercooked or cured meat products. Evidence obtained in vitro and in vivo indicates that SkMCs are indeed a preferred cell type for tissue cyst formation and long-term persistence of T. gondii. This raises intriguing questions about what makes SkMCs a suitable environment for parasite persistence and how the SkMC-T. gondii interaction is regulated. Recent data from our laboratory show that differentiation of SkMCs from myoblasts to syncytial myotubes, rather than the cell type itself, is critical for parasite growth, bradyzoite formation and tissue cyst maturation. Myotube formation is accompanied by a permanent withdrawal from the cell cycle, and the negative cell cycle regulator cell division autoantigen (CDA)-1 directly or indirectly promotes T. gondii stage conversion in SkMCs. Moreover, host cell cycle regulators are specifically modulated in mature myotubes, but not myoblasts, following infection. Myotubes also up-regulate the expression of various pro-inflammatory cytokines and chemokines after T. gondii infection and they respond to IFN-γ by exerting potent anti-parasitic activity. This highlights that mature myotubes are active participants rather than passive targets of the local immune response to T. gondii which may also govern the interaction between SkMCs and the parasite.
- International journal for parasitology.Int J Parasitol.2014 Feb;44(2):91-8. doi: 10.1016/j.ijpara.2013.10.001. Epub 2013 Oct 30.
- Toxoplasma gondii infects virtually any nucleated cell type of warm-blooded animals and humans including skeletal muscle cells (SkMCs). Infection of SkMCs by T. gondii, differentiation from the highly replicative tachyzoites to dormant bradyzoites and tissue cyst formation are crucial for parasite p
- PMID 24184158
- Optimization of the fermentation conditions of Rhizopus japonicus M193 for the production of chitin deacetylase and chitosan.
- Zhang H, Yang S, Fang J, Deng Y, Wang D, Zhao Y.Author information School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China.AbstractTo improve the production of chitin deacetylase (CDA) for the bioconversion of chitin to chitosan with desirable functionality, the effect of the nutritional requirement on the CDA production from Rhizopus japonicus M193 fermentation was investigated under submerged conditions. Nutritional elements including glucose (g/L), inoculum level (%), and MgSO4·7H2O (g/L), as well as culture time (d) were identified as the most critical factors for the CDA production based on the results from Plackett-Burman design (PBD). Taguchi design with orthogonal array was further employed to optimize R. japonicus M193 fermentation conditions based on the results from PBD, in which 2.5% chitin, 5 g/L glucose, 5% inoculum level, 0.6g/L MgSO4·7H2O, and 5d culture time were identified as the optimal fermentation conditions. Under this condition, the maximum CDA production, DDA and MM of produced chitosan were 547.38 ± 12.06 U/L, 78.85 ± 1.68%, and 125.63 ± 3.74 kDa, respectively. Obtained chitosan displayed similar physicochemical and structural properties to those of commercial chitosan extracted using chemical method based on the results from Fourier transform infrared spectrometer (FT-IR), thermogravimetric analysis (TGA)-differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR) assays, while the use of chemical reagents was significantly reduced.
- Carbohydrate polymers.Carbohydr Polym.2014 Jan 30;101:57-67. doi: 10.1016/j.carbpol.2013.09.015. Epub 2013 Sep 14.
- To improve the production of chitin deacetylase (CDA) for the bioconversion of chitin to chitosan with desirable functionality, the effect of the nutritional requirement on the CDA production from Rhizopus japonicus M193 fermentation was investigated under submerged conditions. Nutritional elements
- PMID 24299749
Japanese Journal
- 溶融ジェットの微粒化に及ぼす界面固化の影響
- 日本機械学会論文集 81(830), 15-00147-15-00147, 2015
- NAID 130005105257
- 溶融ジェットの微粒化に及ぼす界面固化の影響
- 日本機械学会論文集 advpub(0), 2015
- NAID 130005096543
- Chlorhexidine-releasing orthodontic elastomerics
- Dental Materials Journal 34(3), 321-326, 2015
- NAID 130005074671
Related Links
- キャリアカウンセラーは、個人の興味、能力、価値観、その他の特性をもとに、個人 にとって望ましいキャリアの選択・開発を支援するキャリア形成の専門家です。
- 日本キャリア開発協会（JCDA）ではCDA資格試験の実施、JCDA会員へのサービス 提供,各種スキルアップ研修の実施、就職活動支援、キャリア教育支援等のキャリア カウンセリングに関わる事業に取り組んでおります。
Related Pictures
★リンクテーブル★
| リンク元 | 「先天性赤血球異形成貧血」 |
| 拡張検索 | 「DCDA」「AICDA deficiency」「CDAI」 |
| 関連記事 | 「C」「CD」 |
「先天性赤血球異形成貧血」
- 英
- congenital dyserythropoietic anemia, CDA
- 同
- 先天性赤血球系異形成貧血？？？？、先天性異常造血性貧血
- 関
- 遺伝性酸溶血試験陽性多核赤芽球症、赤血球異形成貧血
「DCDA」
[★] 未熟児の動脈管開存 delayed closure of ductus arteriosus
「AICDA deficiency」
「CDAI」
「C」
- 炭素 carbon
- シトシン cytosine
- システイン cysteine
- シチジン
- セルシウス度 摂氏 degrees Celsius degree C
- 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語
「CD」