- 同
- activation-induced cytidine deaminase
PrepTutorEJDIC
- 〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 高IgM症候群 hyperimmunoglobulin m syndromes
- 2. 原発性の体液性免疫不全：概要 primary humoral immunodeficiencies an overview
English Journal
- Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.
- Lindsley AW1, Saal HM2, Burrow TA2, Hopkin RJ2, Shchelochkov O3, Khandelwal P4, Xie C5, Bleesing J4, Filipovich L4, Risma K6, Assa'ad AH6, Roehrs PA7, Bernstein JA8.
- The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2015 Jul 17. pii: S0091-6749(15)00788-5. doi: 10.1016/j.jaci.2015.06.002. [Epub ahead of print]
- BACKGROUND: Kabuki syndrome (KS) is a complex multisystem developmental disorder associated with mutation of genes encoding histone-modifying proteins. In addition to craniofacial, intellectual, and cardiac defects, KS is also characterized by humoral immune deficiency and autoimmune disease, yet no
- PMID 26194542
- Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.
- Hu W1, Begum NA1, Mondal S1, Stanlie A1, Honjo T2.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 May 5;112(18):5791-6. doi: 10.1073/pnas.1506167112. Epub 2015 Apr 20.
- Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1
- PMID 25902538
- B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.
- Pone EJ1, Lam T2, Lou Z1, Wang R3, Chen Y4, Liu D4, Edinger AL5, Xu Z6, Casali P6.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Apr 1;194(7):3065-78. doi: 10.4049/jimmunol.1401896. Epub 2015 Mar 4.
- Class switch DNA recombination (CSR) is central to the maturation of the Ab response because it diversifies Ab effector functions. Like somatic hypermutation, CSR requires activation-induced cytidine deaminase (AID), whose expression is restricted to B cells, as induced by CD40 engagement or dual TL
- PMID 25740947
Related Links
- ... reported genetic variant of AICDA gene and the development of Common variable immunodeficiency or selective IgA deficiency demonstrates that intensity of malaria transmission correlates with AID expression levels in the ...
- 1. Cell. 2000 Sep 1;102(5):565-75. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Revy P(1), Muto T, Levy Y, Geissmann F, Plebani A ...
★リンクテーブル★
[★]
- 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
- 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの
- 関
- absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve
[★]
- 関
- activation-induced cell death
[★]
赤池の情報量基準
- 関
- Akaike information criterion