- 関
- vesicular glutamate transport protein、VGLUT
WordNet
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
- a long truck for carrying motor vehicles (同)car transporter
- a crane for moving material with dispatch as in loading and unloading ships
- of or relating to or involving vesicles; "normal vesicular breathing"
- a salt or ester of glutamic acid
PrepTutorEJDIC
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
- 自動車運搬用大型トラック
- 小嚢の小胞の,小嚢(小胞)状の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/05/27 23:10:51」(JST)
[Wiki en表示]
SLC17A7 |
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Identifiers |
Aliases |
SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7 |
External IDs |
MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7 |
Gene ontology |
Molecular function |
• inorganic phosphate transmembrane transporter activity
• sodium:inorganic phosphate symporter activity
• extracellular-glutamate-gated chloride channel activity
• symporter activity
• L-glutamate transmembrane transporter activity
• sodium-dependent phosphate transmembrane transporter activity
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Cellular component |
• postsynapse
• integral component of membrane
• membrane
• synaptic vesicle
• plasma membrane
• synapse
• excitatory synapse
• synaptic vesicle membrane
• cerebellar mossy fiber
• presynaptic active zone
• cell junction
• intracellular organelle
• neuron projection
• clathrin-sculpted glutamate transport vesicle membrane
• cytoplasmic vesicle
• integral component of synaptic vesicle membrane
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Biological process |
• phosphate ion transport
• synaptic transmission, glutamatergic
• sodium-dependent phosphate transport
• sodium ion transport
• chloride transmembrane transport
• ion transport
• glutamate secretion
• synaptic vesicle lumen acidification
• brain development
• long-term memory
• excitatory postsynaptic potential
• transport
• neurotransmitter transport
• neural retina development
• L-glutamate import
• sequestering of neurotransmitter
• sodium ion transmembrane transport
• transmembrane transport
• chemical synaptic transmission
• phosphate ion transmembrane transport
• L-glutamate transmembrane transport
• neurotransmitter loading into synaptic vesicle
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Sources:Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) |
Chr 19: 49.43 – 49.44 Mb |
Chr 7: 45.16 – 45.18 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
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Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[3][4][5]
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[5]
See also
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143.
- ^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226.
- ^ a b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".
Further reading
- Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.". Science. 289 (5481): 957–60. doi:10.1126/science.289.5481.957. PMID 10938000.
- Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.". Nature. 407 (6801): 189–94. doi:10.1038/35025070. PMID 11001057.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons.". Schizophrenia Research. 73 (2-3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259.
- Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex.". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236.
- Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis.". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361.
- Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968 . PMID 17660252.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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Symporter, Cotransporter |
- Na+/K+,Cl−
- Na+/Pi3
- Na+/Cl−
- Na+/glucose
- Na+/I−
- Cl−/K+
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Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
- Cl−-formate
- Cl−-oxalate
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see also solute carrier disorders
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UpToDate Contents
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English Journal
- Localization of the M2 muscarinic cholinergic receptor in dendrites, cholinergic terminals, and noncholinergic terminals in the rat basolateral amygdala: An ultrastructural analysis.
- Muller JF1, Mascagni F1, Zaric V1, Mott DD1, McDonald AJ1.
- The Journal of comparative neurology.J Comp Neurol.2016 Aug 15;524(12):2400-17. doi: 10.1002/cne.23959. Epub 2016 Feb 8.
- Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basolateral nucleus (BLa) is critical for the consolidation of memories of emotionally arousing events. The present investigation used immunocytochemistry at the electron microscopic level to determine which structures in the BLa expre
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- Microconnectomics of the pretectum and ventral thalamus in the chicken (Gallus gallus).
- Vega-Zuniga T1, Marín G2,3, González-Cabrera C2, Planitscher E1, Hartmann A1, Marks V1, Mpodozis J2, Luksch H1.
- The Journal of comparative neurology.J Comp Neurol.2016 Aug 1;524(11):2208-29. doi: 10.1002/cne.23941. Epub 2015 Dec 23.
- The avian pretectal and ventrothalamic nuclei, encompassing the griseum tectale (GT), n. lentiformis mesencephali (LM), and n. geniculatus lateralis pars ventralis (GLv), are prominent retinorecipient structures related to optic flow operations and visuomotor control. Hence, a close coordination of
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- Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons.
- Silva JN1, Lucena EV2, Silva TM2, Damasceno RS2, Takakura AC1, Moreira TS3.
- Neuroscience.Neuroscience.2016 Jul 22;328:9-21. doi: 10.1016/j.neuroscience.2016.04.028. Epub 2016 Apr 26.
- The Kölliker-Fuse (KF) region, located in the dorsolateral pons, projects to several brainstem areas involved in respiratory regulation, including the chemoreceptor neurons within the retrotrapezoid nucleus (RTN). Several lines of evidence indicate that the pontine KF region plays an important role
- PMID 27126558
Japanese Journal
- P2Y4 Nucleotide Receptor in Neuronal Precursors Induces Glutamatergic Subtype Markers in Their Descendant Neurons
- The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways
- Expression of Vesicular Nucleotide Transporter in the Mouse Retina
Related Links
- Glutamate, the major neurotransmitter in the retina, is loaded into synaptic vesicles by a family of proteins known as vesicular glutamate transporters (VGLUTs) [1]. This protein family consists of three distinct yet highly ...
- Before exocytotic release, classical (nonpeptide) neurotransmitters, such as L-glutamate, are stored into synaptic vesicles by proton-driven membrane transporters. Either of two vesicular glutamate transporters, VGLUT1 and VGLUT2, is expressed in classical glutamatergic nerve terminals establishing ...
★リンクテーブル★
[★]
- 英
- vesicular glutamate transporter、VGLUT
- 関
- 小胞グルタミン酸輸送タンパク質、小胞グルタミン酸トランスポーター
[★]
- 関
- vesicular glutamate transport protein、vesicular glutamate transporter
[★]
- 英
- vesicular glutamate transporter
- 関
- 小胞グルタミン酸輸送体
[★]
- 関
- vesicular glutamate transport protein 1、VGLUT1
[★]
- 関
- vesicular glutamate transport protein 2、VGLUT2
[★]
- 関
- bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation
[★]
- 関
- amino acid transport system X-AG、glutamate-aspartate transporter
[★]
グルタミン酸、グルタメート、グルタメイト、(化合物)グルタミン酸塩
[★]
トランスポーター
- 関
- translocator、transport protein、transporter protein
[★]
- 関
- vesicle