KCNQ5/Kv7.5 is a low-threshold non-inactivating voltage-gated potassium channel preferentially targeted to excitatory endings in brain neurons. The M-type current is mediated by KCNQ5 channel subunits in monkey retinal pigment epithelium cells and in brain neurons. This study was undertaken to analy
Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell.
Truitt WA1, Hauser SR, Deehan GA Jr, Toalston JE, Wilden JA, Bell RL, McBride WJ, Rodd ZA.
Psychopharmacology.Psychopharmacology (Berl).2015 Feb;232(3):639-49. doi: 10.1007/s00213-014-3702-3. Epub 2014 Aug 26.
RATIONALE: Ethanol and nicotine are frequently co-abused. The biological basis for the high co-morbidity rate is not known. Alcohol-preferring (P) rats will self-administer EtOH or nicotine directly into the posterior ventral tegmental area (pVTA).OBJECTIVE: The current experiments examined whether
Delaying the onset of treadmill exercise following peripheral nerve injury has different effects on axon regeneration and motoneuron synaptic plasticity.
Brandt J1, Evans JT1, Mildenhall T1, Mulligan A1, Konieczny A1, Rose SJ, English AW2.
Journal of neurophysiology.J Neurophysiol.2015 Jan 28:jn.00892.2014. doi: 10.1152/jn.00892.2014. [Epub ahead of print]
Transection of a peripheral nerve results in withdrawal of synapses from motoneurons. Some of the withdrawn synapses are restored spontaneously, but those containing the vesicular glutamate transporter 1 (VGLUT1), and arising mainly from primary afferent neurons, are withdrawn permanently. If animal
Measurement of saturation processes in glutamatergic and GABAergic synapse densities during long-term development of cultured rat cortical networks
Ito Daisuke,Komatsu Takumi,Gohara Kazutoshi
Brain research 1534, 22-32, 2013-10-09
… During this culture period, we labeled glutamatergic and GABAergic synapses separately using antibodies against vesicular glutamate transporter 1 (VGluT1) and vesicular transporter of gamma-aminobutyric acid (VGAT). …
Vesicular Glutamate Transporter 2 Expression in the Rat Pineal Gland: Detailed Analysis of Expression Pattern and Regulatory Mechanism
YOSHIDA Sachine,HISANO Setsuji
Kansei Engineering International Journal 11, 133-137, 2012
… Under circadian control, melatonin secretion is modulated via nocturnal autonomic (adrenergic) stimulation to the gland, which expresses vesicular glutamate transporter (VGLUT) 1, VGLUT2 and a VGLUT1 splice variant (VGLUT1v), glutamatergic markers. … Stimulation of either β-adrenergic receptor or cAMP production to the pineal cells was shown to increase mRNA level of VGLUT2, but not VGLUT1 and VGLUT1v. …