小胞グルタミン酸輸送体1、小胞グルタミン酸トランスポーター1

関: vesicular glutamate transport protein 1、VGLUT1

WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
of or relating to or involving vesicles; "normal vesicular breathing"
a salt or ester of glutamic acid

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
自動車運搬用大型トラック
小嚢の小胞の,小嚢(小胞)状の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/23 10:07:46」(JST)

wiki en

[Wiki en表示]

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5]^[6]^[7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104888 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070570 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143.
^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226.
^ ^a ^b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

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English Journal

Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801.

Farley S, Dumas S, El Mestikawy S, Giros B.SourceINSERM U952 Physiopathologie des Maladies du Système nerveux Central, 9 Quai St Bernard, 75005 Paris, France.
Neuropharmacology.Neuropharmacology.2012 Jan;62(1):503-17. Epub 2011 Sep 17.
Major depression is a chronic psychiatric illness that is highly prevalent and disabling. The available medications are ineffective for many patients suggesting that differents molecular pathways could be specifically altered in the unresponsive patients. Recently, the glutamatergic system has emerg
PMID 21945287

Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice.

Broadstock M, Lewinsky R, Jones EL, Mitchelmore C, Howlett DR, Francis PT.SourceKing's College London, Wolfson Centre for Age-Related Diseases, London, SE1 1UL, UK.
Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm.2011 Nov 5. [Epub ahead of print]
Dietary factors may play a role in Alzheimer's disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet
PMID 22057511

Japanese Journal

Development of an anatomical technique for visualizing the mode of climbing fiber innervation in Purkinje cells and its application to mutant mice lacking GluRδ2 and Cav2.1

Miyazaki Taisuke,Watanabe Masahiko
Anatomical Science International 86(1), 10-18, 2011-03
… Soon after the identification of type 2 vesicular glutamate transporter (VGluT2) that selectively detects CF terminals in the molecular layer, we developed a novel method of combined anterograde tracer labeling and VGluT2 immunohistochemistry. …
NAID 80021570304

Possible Involvement of Glutamatergic Signaling Machineries in Pathophysiology of Rheumatoid Arthritis

Hinoi Eiichi,Yoneda Yukio
Journal of Pharmacological Sciences 116(3), 248-256, 2011
… The prevailing view is that L-glutamate (Glu) functions as an excitatory amino acid neurotransmitter through a number of molecular machineries required for the neurocrine signaling at synapses in the brain. … These include Glu receptors for signal input, Glu transporters for signal termination, and vesicular Glu transporters for signal output through exocytotic release. …
NAID 130001014455

「VGLUT1」

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,442,360 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,176,142 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• inorganic phosphate transmembrane transporter activity; • sodium:inorganic phosphate symporter activity; • extracellular-glutamate-gated chloride channel activity; • symporter activity; • L-glutamate transmembrane transporter activity; • sodium-dependent phosphate transmembrane transporter activity;
Cellular component	• postsynapse; • integral component of membrane; • membrane; • synaptic vesicle; • plasma membrane; • synapse; • excitatory synapse; • synaptic vesicle membrane; • cerebellar mossy fiber; • presynaptic active zone; • cell junction; • intracellular organelle; • neuron projection; • clathrin-sculpted glutamate transport vesicle membrane; • cytoplasmic vesicle; • integral component of synaptic vesicle membrane;
Biological process	• phosphate ion transport; • synaptic transmission, glutamatergic; • sodium-dependent phosphate transport; • sodium ion transport; • chloride transmembrane transport; • ion transport; • glutamate secretion; • synaptic vesicle lumen acidification; • brain development; • long-term memory; • excitatory postsynaptic potential; • neurotransmitter transport; • neural retina development; • L-glutamate import; • sequestering of neurotransmitter; • sodium ion transmembrane transport; • transmembrane transport; • chemical synaptic transmission; • phosphate ion transmembrane transport; • L-glutamate transmembrane transport; • neurotransmitter loading into synaptic vesicle;
	Sources:Amigo / QuickGO
Orthologs
	57030
	72961
	ENSG00000104888
	ENSMUSG00000070570
	Q9P2U7
	Q3TXX4
	NM_020309
	NM_182993
	NP_064705
	NP_892038
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★] 小胞グルタミン酸輸送体1

関: vesicular glutamate transport protein 1、vesicular glutamate transporter 1

「小胞グルタミン酸輸送体1」

　　[★]

英: vesicular glutamate transporter 1、VGLUT1
関: 小胞グルタミン酸トランスポーター1

「小胞グルタミン酸トランスポーター1」

　　[★]

英: vesicular glutamate transporter 1
関: 小胞グルタミン酸輸送体1

「transport」

　　[★]

n.

輸送、運搬

v.

輸送する、運搬する、運ぶ

関: bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

「glutamate transporter」

　　[★]

グルタミン酸トランスポーター、グルタミン酸輸送体

関: amino acid transport system X-AG、glutamate-aspartate transporter

「glutamate」

　　[★]

グルタミン酸、グルタメート、グルタメイト、(化合物)グルタミン酸塩

「transporter」

　　[★] トランスポーター

関: translocator、transport protein、transporter protein

「vesicular」

　　[★]

adj.

小胞の

関: vesicle

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104888 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070570 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8632143-5] Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143.

[pmid10820226-6] Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226.

[entrez-7] "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

リンク元	「VGLUT1」「小胞グルタミン酸輸送体1」「小胞グルタミン酸トランスポーター1」
関連記事	「transport」「glutamate transporter」「glutamate」「transporter」「vesicular」

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案内

案内

vesicular glutamate transporter 1