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WordNet

give a structure to; "I need to structure my days"
a thing constructed; a complex entity constructed of many parts; "the structure consisted of a series of arches"; "she wore her hair in an amazing construction of whirls and ribbons" (同)construction
the manner of construction of something and the arrangement of its parts; "artists must study the structure of the human body"; "the structure of the benzene molecule"
a particular complex anatomical part of a living thing; "he has good bone structure" (同)anatomical structure, complex body part, bodily structure, body structure
the complex composition of knowledge as elements and their combinations; "his lectures have no structure"
a relation between people; (`relationship is often used where `relation would serve, as in `the relationship between inflation and unemployment, but the preferred usage of `relationship is for human relations or states of relatedness); "the relationship between mothers and their children" (同)human_relationship
a state involving mutual dealings between people or parties or countries
a state of connectedness between people (especially an emotional connection); "he didnt want his wife to know of the relationship"
any specific behavior; "they avoided all recreational activity"
(chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity"
having definite and highly organized structure; "a structured environment"

PrepTutorEJDIC

{C}(建物・橋などの)建造物 / {U}(…の)構造,誠成,組織《+of~名》 / {C}構造(構成)体,組織体 / 〈思想など〉‘を'組み立てる,組織化する
=relation 1 / 血縁関係,親族関係
〈U〉『活動』,働き;活力 / 《しばしば複数形で》(種々の)『活動』,行事;(学生の)学内(外)活動,クラブ活動 / 〈U〉(商況・市場などの)活発,活気

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/18 05:07:31」(JST)

wiki en

The structure–activity relationship (SAR) is the relationship between the chemical or 3D structure of a molecule and its biological activity. The analysis of SAR enables the determination of the chemical group responsible for evoking a target biological effect in the organism. This allows modification of the effect or the potency of a bioactive compound (typically a drug) by changing its chemical structure. Medicinal chemists use the techniques of chemical synthesis to insert new chemical groups into the biomedical compound and test the modifications for their biological effects.

This method was refined to build mathematical relationships between the chemical structure and the biological activity, known as quantitative structure–activity relationships (QSAR). A related term is structure affinity relationship (SAFIR).

Structure-biodegradability relationship

The large number of synthetic organic chemicals currently in production presents a huge challenge for timely collection of detailed environmental data on each compound. The concept of structure biodegradability relationships (SBR) has been applied to explain variability in persistence among organic chemicals in the environment. Early attempts generally consisted of examining the degradation of a homologous series of structurally related compounds under identical conditions with a complex "universal" inoculum, typically derived from numerous sources.^[1] This approach revealed that the nature and positions of substituents affected the apparent biodegradability of several chemical classes, with resulting general themes, such as halogens generally conferring persistence under aerobic conditions.^[2] Subsequently, more quantitative approaches have been developed using principles of QSAR and often accounting for the role of sorption (bioavailability) in chemical fate.^[3]

References

^ Sims, Gerald; Sommers (1986). "Biodegradation of pyridine derivatives in soil suspensions". Environmental Toxicology and Chemistry. 5: 503–509. doi:10.1002/etc.5620050601.
^ Alexander, Martin; Lustigman (1966). "Effect of chemical structure on microbial degradation of substituted benzenes". J. Agric. Food Chem. 14: 410–413. doi:10.1021/jf60146a022. Retrieved 2013-04-04.
^ Mani, S.V.; D.W. Connell; R.D. Braddock (1991). "Structure activity relationships for the prediction of biodegradability of environmental pollutants". Critical Reviews in Environmental Control. 21 (3,4): 217–236. doi:10.1080/10643389109388416.

External links

Molecular Property Explorer
QSAR World

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. インスリン受容体の構造および機能 structure and function of the insulin receptor
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5. 癌生存における食事、身体活動、および体重の役割 the roles of diet physical activity and body weight in cancer survivorship

English Journal

Targeted acylation for all the hydroxyls of (+)-catechin and evaluation of their individual contribution to radical scavenging activity.

Hong S1, Liu S2.
Food chemistry.Food Chem.2016 Apr 15;197(Pt A):415-21. doi: 10.1016/j.foodchem.2015.10.134. Epub 2015 Oct 29.
The reactivity profile of all the hydroxyl groups in (+)-catechin towards acylation and their respective contribution to radical scavenging activity were systematically explored in this work. Selective acylation of the hydroxyls on different rings was carried out employing either a basic or acidic a
PMID 26616969

Antiradical and reductant activities of anthocyanidins and anthocyanins, structure-activity relationship and synthesis.

Ali HM1, Almagribi W2, Al-Rashidi MN2.
Food chemistry.Food Chem.2016 Mar 1;194:1275-82. doi: 10.1016/j.foodchem.2015.09.003. Epub 2015 Sep 3.
Eight anthocyanidins, seven anthocyanins and two synthesized 4'-hydroxy flavyliums were examined as hydrogen donors to DPPH, ABTS and hydroxyl radicals, and as electron donors in the FRAP assay. Most compounds gave better activities than trolox and catechol. A structure-activity relationship (SAR) s
PMID 26471682

Relationship between structure and immunological activity of an arabinogalactan from Lycium ruthenicum.

Peng Q1, Liu H2, Lei H2, Wang X2.
Food chemistry.Food Chem.2016 Mar 1;194:595-600. doi: 10.1016/j.foodchem.2015.08.087. Epub 2015 Aug 22.
An immunologically active arabinogalactan (LRGP3) was selectively degraded by acetolysis, mild acid hydrolysis and enzymatic digestion. After exo-α-l-arabinofuranosidase digestion, 56% of the arabinosyl chains were released. The resistant product (LRGP3-AF) had markedly increased complement fixatin
PMID 26471597

Japanese Journal

Calcitonin-typical suppression of osteoclastic activity by amphioxus calcitonin superfamily peptides and insights into the evolutionary conservation and diversity of their structures

General and Comparative Endocrinology 246, 294-300, 2017-05-15
NAID 120005973614

Picolinic Acid系オーキシン除草剤における構造変換 (殺虫剤研究/QSAR研究の進歩)

日本農薬学会誌 = Japanese journal of pesticide science 42(1), 28-32, 2017-02
NAID 40021121459

STRUCTURE-ACTIVITY RELATIONSHIP OF PHENYLETHANOID GLYCOSIDES ON THE INHIBITION OF AMYLOID Β AGGREGATION

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 92(11), 1976-1982, 2016-11-01
NAID 40021014923

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★リンクテーブル★

リンク元	「structure-activity correlation」
拡張検索	「quantitative structure-activity relationship」「3D-quantitative structure-activity relationship」
関連記事	「relationship」「structure」「activity」