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1. 頭頸部癌に対する治療の概要overview of treatment for head and neck cancer [show details]
…upper aerodigestive tract, and these are predominantly squamous cell carcinomas. An overview of treatment for head and neck squamous cell carcinomas will be presented here. An overview of the diagnostic …
2. 皮膚扁平上皮細胞癌および基底細胞癌における局所および遠隔転移の評価evaluation for locoregional and distant metastases in cutaneous squamous cell and basal cell carcinoma [show details]
… In the majority of patients with cutaneous squamous cell carcinoma (SCC) or basal cell carcinoma (BCC), disease remains limited to the skin and is successfully managed with local therapy, such as excision …
3. 原発不明癌の分類およびマネージメントの概要overview of the classification and management of cancers of unknown primary site [show details]
…metastases or an elevated serum prostate specific antigen (PSA), in whom treatment for metastatic prostate cancer may be useful . Squamous cell carcinoma (SCC) limited to cervical lymph nodes, which may …
4. 原発不明の頭頸部扁平上皮癌head and neck squamous cell carcinoma of unknown primary [show details]
… Head and neck squamous cell carcinoma (SCC) of unknown primary is defined as the presence of SCC in one or more lymph nodes within the head and neck region that are not solely in the supraclavicular region …
5. 高リスク (浸潤性) 皮膚扁平上皮癌の認識およびマネージメントrecognition and management of high risk aggressive cutaneous squamous cell carcinoma [show details]
… Cutaneous squamous cell carcinoma (cSCC) is a relatively common malignancy derived from epidermal keratinocytes. Although most patients with cSCC present with localized disease that is cured with local …

English Journal

Squamous cell carcinoma-related antigen 2 level is a reliable indicator of severe psoriasis involving the face.

Zhang Y, Guo D, Deng H, Li H, Chen Y, Xiao Q, Wu M, Xu R, Li B, Li F.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 2019 Jun;154(3)374-375.
PMID 31001969

Facile fabrication of visible light photoelectrochemical immunosensor for SCCA detection based on BiOBr/BiS heterostructures via self-sacrificial synthesis method.

Fan D, Bao C, Liu X, Feng J, Wu D, Ma H, Wang H, Wei Q, Du B.
Talanta. 2019 Jun;198()417-423.
A novel visible light photoelectrochemical immunosensor based on BiOBr/BiS heterostructures was fabricated to detect squamous cell carcinoma antigen (SCCA). BiS nanoparticles formed on the BiOBr microflowers by the self-sacrificial synthesis method based on the facile reaction between BiOBr and S io
PMID 30876581

Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity.

Turato C, Scarpa M, Kotsafti A, Cappon A, Quarta S, Biasiolo A, Cavallin F, Trevellin E, Guzzardo V, Fassan M, Chiarion-Sileni V, Castoro C, Rugge M, Vettor R, Scarpa M, Pontisso P.
Cancer science. 2019 May;110(5)1552-1563.
Squamous cell carcinoma antigen-1 (SCCA1) overexpression is associated with poor prognosis and chemoresistance in several tumor types, however, the underlying mechanisms remain elusive. Here, we report SCCA1 in relation to the immune and peritumoral adipose tissue microenvironment in early and advan
PMID 30825353

Japanese Journal

Characteristics and prognosis of Japanese male and female lung cancer patients : The BioBank Japan Project

Nakamura Koshi,Ukawa Shigekazu,Okada Emiko,Hirata Makoto,Nagai Akiko,Yamagata Zentaro,Ninomiya Toshiharu,Muto Kaori,Kiyohara Yutaka,Matsuda Koichi,Kamatani Yoichiro,Kubo Michiaki,Nakamura Yusuke,BioBank Japan Cooperative Hospital Group,Tamakoshi Akiko
Journal of epidemiology 27(3), S49-S57, 2017-03
… Background: In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively. …
NAID 120006219884

Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project

Nakamura Koshi,Matsuda Koichi,Kamatani Yoichiro,Kubo Michiaki,Nakamura Yusuke,BioBank Japan Cooperative Hospital Group,Tamakoshi Akiko,Ukawa Shigekazu,Okada Emiko,Hirata Makoto,Nagai Akiko,Yamagata Zentaro,Ninomiya Toshiharu,Muto Kaori,Kiyohara Yutaka
Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 27(Supplement_III), S49-S57, 2017
… In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively.</p><p><i>Methods:</i> …
NAID 130006832566

Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis

Ishihara Shunji,Matsumoto Kenji,Kinoshita Yoshikazu,Shoda Tetsuo,Ishimura Norihisa,Ohta Shoichiro,Ono Junya,Azuma Yoshinori,Okimoto Eiko,Izuhara Kenji,Nomura Ichiro
Internal Medicine 56(21), 2819-2825, 2017
… This study was conducted to examine the possible value of eosinophil-related proteins as serum biomarkers. … In contrast, the B cell-attracting chemokine (BCA)-1/chemokine (C-X-C motif) ligand (CXCL) 13 and hemofiltrate C-C chemokine (HCC)-1/CC chemokine ligand (CCL) 14α levels were significantly elevated, while the granulocyte chemotactic protein (GCP)-2/CXCL6 levels were suppressed in patients with eosinophilic esophagitis as well as in those with eosinophilic gastroenteritis. …
NAID 130006191952

「SCC抗原」

　　[★]

英: squamous cell carcinoma related antigen, SCC antigen
同: SCC ←　検査項目として省略されるが、squamous cell carcinomaの略でもある; 扁平上皮癌関連抗原 squamous cell carcinoma antigen
関: CYFRA21-1

概念

子宮頚部扁平上皮癌から精製された蛋白質
早期癌でも比較的高い陽性率を示し、経過観察にも有用である。
一般に扁平上皮の存在する部位に広範な重症疾患存在すれば血中のSCCは上昇しうる
皮膚表面、唾液中に大量に存在し、採血時に複数回穿刺する事などによるコンタミネーションの可能性がある。

子宮頚癌(扁平上皮癌)、腟扁平上皮癌、外陰癌

基準値

＜1.5 ng/ml

鑑別疾患

性疾患	陽性率	良性疾患	陽性率
子宮頸癌	20～80％	良性皮膚疾患	80～100％
外陰・膣癌	31～39%	気管支喘息、気管支炎	0.05
肺癌（扁平上皮癌）	35～57%	急性/慢性肺炎	3～18%
食道癌	43～64%	結核、サルコイドーシス	0.09
頭頸部癌	44～71%	肺良性腫瘍	0.25
皮膚癌	0.5	腎不全、透析患者	0.6
肛門癌	44～78%	肝炎	0.09
口腔・舌・上顎癌	34～64%	肝硬変	0.52
肝細胞癌	0.84