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1. 軟骨無形成症achondroplasia [show details]
… death. Homozygous achondroplasia results from transmission of the FGFR3 mutation from both parents who have achondroplasia. Clinically, this presents as a severe form of achondroplasia resembling the bone …
2. ランバートイートン筋無力症候群：臨床的特徴および診断lambert eaton myasthenic syndrome clinical features and diagnosis [show details]
… reduced acetylcholine (ACh) release from the presynaptic nerve terminals. Antibodies directed against the voltage-gated calcium channel (VGCC) interfere with the… a variety of clinical situations where LEMS is not present. If these studies are not definitive, single-fiber electromyography (SFEMG) can be diagnostic for a neuromuscular junction disorder but is less …
3. 血管攣縮性狭心症vasospastic angina [show details]
… injection of acetylcholine (ACh) . After six months, in which all patients received calcium channel blocker therapy, the percentage of patients with ACh-induced coronary artery… suggesting that a single receptor pathway cannot explain the phenomenon .… This interesting concept requires further investigation since the current data are limited to isolated case reports.…
4. 骨系統疾患：特定の疾患skeletal dysplasias specific disorders [show details]
… caused by heterozygous mutations in the chloride channel 7 (CLCN7) gene .…contributed to the development of treatment options for specific skeletal dysplasias, such as achondroplasia, hypophosphatasia, and osteogenesis imperfecta. A few of the most common conditions are reviewed …
5. 多発神経根症：脊柱管狭窄症、感染症、癌、および炎症性神経根症候群polyradiculopathy spinal stenosis infectious carcinomatous and inflammatory nerve root syndromes [show details]
… 60 to 90 percent of single-level radiculopathies occur in the lumbosacral levels.… characterized by an aching that begins in the buttocks and descends into the knees,… such as tricyclic agents, dual reuptake inhibitors of serotonin and norepinephrine, or calcium channel alpha 2-delta ligands (gabapentin and pregabalin). Our preferred agents are gabapentin titrated …

English Journal

Atrial-selective K channel blockers: potential antiarrhythmic drugs in atrial fibrillation?

, R R, U U, U U, .
Canadian journal of physiology and pharmacology. 2017 Nov;95(11)1313-1318.
In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medications, atrial-selective drugs that specifically target atrial ov
PMID 28738160

Chloroform Extract of L. Relaxes Mouse Airway Smooth Muscle.

Huang J, Ma LQ, Yang Y, Wen N, Zhou W, Cai C, Liu QH, Shen J.
Evidence-based complementary and alternative medicine : eCAM. 2017 ;2017()9870414.
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PMID 29259649

Effects of tertiapin-Q and ZD7288 on changes in sinoatrial pacemaker rhythm during vagal stimulation.

Han SY, Bolter CP.
Autonomic neuroscience : basic & clinical. 2015 Dec;193()117-26.
Heart rate slowing produced by cardiac parasympathetic (vagal) stimulation is thought to be the result of modulation of the acetylcholine-activated K(+) current (IK,ACh) and the pacemaker current (If) in sinoatrial (SAN) pacemaker cells. However, the contribution of these and other ion currents to v
PMID 26549880

Japanese Journal

SINGLE CHANNEL RECORDING AND SYNAPTIC TRANSMISSION

Kojima Hiroshi
玉川大学脳科学研究所紀要 (6), 15-37, 2013
NAID 40019696281

アメフラシ神経節シナプスにおける伝達物質放出過程解析

小島比呂志,ヤンユムー,塚田稔,ベルナールプーラン
日本生理学会大会発表要旨集 2005(0), S152-S152, 2005
… On the other hand, nonstationary noise analysis were developed to estimate the single channel conductances both in the excitable and postsynaptic membrane of the neurons. … Furthermore, this analysis for estimating single channel conductances has been extended to the amplitude-variance of synaptic responses around the mean-value of synaptic currents. …
NAID 130005447605

Nonselective Cation Channels Activated by the Stimulation of Muscarinic Receptors in Mammalian Gastric Smooth Muscle

SO Insuk,KIM Ki Whan
Journal of smooth muscle research = 日本平滑筋学会機関誌 39(6), 231-247, 2003-12-01
… Single cell RT-PCR experiments showed that all five subtypes of muscarinic receptors were present in circular smooth muscle cells of the guinea-pig gastric antrum. … Nonselective cation channels (NSCC) activated by ACh or CCh are coupled to pertussis toxin (PTX)-sensitive Go protein through m4 subtype as well as m2 and m3 subtypes in guinea-pig stomach. …
NAID 110002912884