無作為プラセボ非継続試験 RDT
WordNet
- (law) the determination of a persons innocence or guilt by due process of law; "he had a fair trial and the jury found him guilty"; "most of these complaints are settled before they go to trial"
- trying something to find out about it; "a sample for ten days free trial"; "a trial of progesterone failed to relieve the pain" (同)trial_run, test, tryout
- an annoying or frustrating or catastrophic event; "his mother-in-laws visits were a great trial for him"; "life is full of tribulations"; "a visitation of the plague" (同)tribulation, visitation
- (sports) a preliminary competition to determine qualifications; "the trials for the semifinals began yesterday"
- set up or distributed in a deliberately random way (同)randomised
- arrange in random order; "Randomize the order of the numbers" (同)randomise
PrepTutorEJDIC
- 〈U〉〈C〉『裁判』,公判,審理 / 〈U〉〈C〉(…の)『試験』,ためし《+of+名》 / 〈C〉企て,試み;努力 / 〈C〉(忍耐・徳・信仰などをためす)試練,苦難 / 〈C〉困りもの,迷惑な(やっかいな)人(もの)
UpToDate Contents
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English Journal
- A Randomized Controlled Trial of Risperidone, Lithium, or Divalproex Sodium for Initial Treatment of Bipolar I Disorder, Manic or Mixed Phase, in Children and Adolescents.
- Geller B, Luby JL, Joshi P, Wagner KD, Emslie G, Walkup JT, Axelson DA, Bolhofner K, Robb A, Wolf DV, Riddle MA, Birmaher B, Nusrat N, Ryan ND, Vitiello B, Tillman R, Lavori P.SourceWashington University in St Louis, Missouri (Drs Geller and Luby and Mss Bolhofner and Tillman); Department of Psychiatry and Behavioral Sciences, Children's National Medical Center, Washington, DC (Drs Joshi, Robb, and Nusrat); Department of Psychiatry, University of Texas Medical Branch, Galveston (Drs Wagner and Wolf), and Department of Psychiatry, University of Texas Southwestern, Dallas (Dr Emslie); Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland (Drs Walkup and Riddle); National Institute of Mental Health, Bethesda, Maryland (Dr Vitiello); Department of Psychiatry, University of Pittsburgh, Pennsylvania (Drs Axelson, Birmaher, and Ryan); and Department of Health Research and Policy, Stanford University, California (Dr Lavori). Dr Walkup is now with the Department of Psychiatry, Weill Cornell Medical College, New York, New York.
- Archives of general psychiatry.Arch Gen Psychiatry.2012 Jan 2. [Epub ahead of print]
- CONTEXT: There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents.OBJECTIVE: To investigate which medication to administer first to antimanic medication-naive subjects. Design, Setting, andPARTICIPANTS:
- PMID 22213771
- Dasatinib combined with docetaxel for castration-resistant prostate cancer: Results from a phase 1-2 study.
- Araujo JC, Mathew P, Armstrong AJ, Braud EL, Posadas E, Lonberg M, Gallick GE, Trudel GC, Paliwal P, Agrawal S, Logothetis CJ.SourceThe University of Texas MD Anderson Cancer Center, Houston, Texas. johna@mdanderson.org.
- Cancer.Cancer.2012 Jan 1;118(1):63-71. doi: 10.1002/cncr.26204. Epub 2011 Jul 25.
- BACKGROUND: To determine the potential efficacy of targeting both the tumor and bone microenvironment in patients with castration-resistant prostate cancer (PC), the authors conducted a phase 1-2 trial combining docetaxel with dasatinib, an oral SRC inhibitor.METHODS: In phase 1, 16 men received das
- PMID 21976132
- The Effect of a 12-Week Course of Omega-3 Polyunsaturated Fatty Acids on Lipid Parameters in Hypertriglyceridemic Adult HIV-infected Patients Undergoing HAART: A Randomized, Placebo-Controlled Pilot Trial.
- Peters BS, Wierzbicki AS, Moyle G, Nair D, Brockmeyer N.SourceDepartment of Infectious Diseases, King's College London, London, United Kingdom.
- Clinical therapeutics.Clin Ther.2011 Dec 31. [Epub ahead of print]
- BACKGROUND: Hypertriglyceridemia is common in patients with HIV treated with highly active antiretroviral therapy (HAART).OBJECTIVE: The goal of this study was to investigate the effect of the polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) 460 mg/eicosapentaenoic acid (EPA) 380 mg on
- PMID 22212377
Japanese Journal
- Impact of Positive Peri-Stent Vascular Remodeling After Sirolimus-Eluting and Paclitaxel-Eluting Stent Implantation on 5-Year Clinical Outcomes : Intravascular Ultrasound Analysis From the Poststent Optimal Stent Expansion Trial Multicenter Randomized Trial
- , , , , , , , , , , ,
- Circulation journal : official journal of the Japanese Circulation Society 76(5), 1102-1108, 2012-04-25
- … paclitaxel-eluting stent [PES], n=121) from the Poststent Optimal Stent Expansion Trial who underwent a post-intervention and 9-month follow-up intravascular ultrasound were followed clinically for 5 years. … Early discontinuation (<1 year) of dual antiplatelet therapy (DAPT; …
- NAID 10030132280
- CLopidogrel Trial in Patients With Elective Percutaneous Coronary Intervention for Stable ANgina and Old Myocardial Infarction (CLEAN):Safety and Efficacy of Clopidogrel Compared to Ticlopidine in Japanese Patients
- , , , , , , ,
- International Heart Journal 53(2), 91-101, 2012
- … However, the benefit to Japanese patients with stable angina (SA) or old myocardial infarction (OMI) undergoing percutaneous coronary intervention (PCI) still remains unclear.The aim of this multicenter, randomized, double-blind, clinical study was to evaluate the safety of a clopidogrel 300 mg loading dose followed by a 75 mg maintenance dose compared to ticlopidine 100 mg twice daily in patients with SA or OMI undergoing PCI who were on aspirin (81 to 100 mg once daily). …
- NAID 130001914134
- Randomized controlled study investigating viral suppression and serological response following pre-S1/pre-S2/S vaccine therapy combined with lamivudine treatment in HBeAg-positive patients with chronic hepatitis B.
- Hoa Pham Thi Le,Huy Nguyen Tien,Thu Le The,Nga Cao Ngoc,Nakao Kazuhiko,Eguchi Katsumi,Chi Nguyen Huu,Hoang Bui Huu,Hirayama Kenji
- Antimicrobial agents and chemotherapy 53(12), 5134-5140, 2009-12
- … We established a randomized, controlled clinical trial to compare the responses of three different treatment groups: those receiving vaccine monotherapy, lamivudine monotherapy, or combination treatment. … This enhanced suppression effect in the combination group was reversed after the discontinuation of vaccine treatment, suggesting that booster doses are required for a sustained viral response. …
- NAID 120001759344
Related Links
- 1. J Clin Epidemiol. 1993 Sep;46(9):959-71. Randomized discontinuation trials: utility and efficiency. Kopec JA, Abrahamowicz M, Esdaile JM. The randomized discontinuation trial (RDT) is a two-phase trial. In phase I all ...
- 1. J Clin Oncol. 2013 Feb 1;31(4):412-9. doi: 10.1200/JCO.2012.45.0494. Epub 2012 Nov 19. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. Smith DC(1 ...
★リンクテーブル★
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randomized discontinuation trial RDT
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- ランダム化治療中止試験
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Randomized Discontinuation Trial randomized discontinuation trial
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- assessment、attempt、clinical research、clinical study、clinical test、clinical trial、effort、exam、examination、examine、investigation、investigational、tentative、tentatively、test、testing
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- abort、break、discontinuance、discontinue、discontinuity、interrupt、interruption、pause、stop、suspend、withdraw、withdrawal
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- random sampling、randomisation、randomise、randomization、randomize
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- randomisation、randomise、randomization、randomized
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