"Pyramidal tract" redirects here. This page refers to the nerve fibres underlying the pyramids. For the actual area of the brain, Pyramids, see Pyramid of medulla oblongata.
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (May 2013) |
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| Brain: Corticospinal tract |
Deep dissection of brain-stem. Lateral view. ("pyramidal tract" visible in red, and "pyramidal decussation" labeled at lower right.)
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Spinal cord tracts, with pyramidal tracts labeled at upper left
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| Latin |
tractus corticospinalis |
| Gray's |
p.759 |
| NeuroNames |
ancil-373 |
| MeSH |
Pyramidal+Tracts |
| NeuroLex ID |
birnlex_1464 |
The pyramidal tracts refer to both the corticospinal and corticobulbar tracts of the nervous system.
The corticospinal tract conducts impulses from the brain to the spinal cord. It contains mostly axons originated from the motor cortex. The corticospinal tract is made up of two separate tracts in the spinal cord: the lateral corticospinal tract and the anterior corticospinal tract. The corticospinal tract also contains betz cells (the largest pyramidal cells), which are not found in any other region of the body. An understanding of these tracts leads to an understanding of why one side of the body is controlled by the opposite side of the brain. The corticospinal tract is concerned specifically with discrete voluntary skilled movements, such as precise movement of the fingers and toes. The brain sends impulses to the spinal cord relaying the message. This is imperative in understanding that the left hemisphere of the brain controls the right side of the body, while the right hemisphere of the brain controls the left side of the body. The tracts cross in the medulla oblongata in a process also known as decussation.
The corticobulbar tract carries information to motor neurons of the cranial nerve nuclei, rather than the spinal cord.[1] These nerves control the muscles of the face and neck and are involved in facial expression, mastication, swallowing, and other functions.
Contents
- 1 Structure
- 1.1 Motor pathway
- 1.1.1 Decussation and synapses
- 1.1.2 From cerebral to motor neurons
- 1.1.3 Lower motor neurons
- 1.2 Sensory
- 1.3 Neurons
- 1.4 Extrapyramidal motor pathways
- 2 Function
- 3 Clinical significance
- 4 Additional images
- 5 References
- 6 External links
Structure[edit]
Motor pathway[edit]
The corticospinal tract originates from pyramidal cells in layer V of the cerebral cortex. About 31% of its fibers arise from the primary motor cortex. Other contributions come from the supplementary motor area and the premotor cortex which constitute 29% of fibers while the somatosensory cortex, parietal lobe, and cingulate gyrus supplies the rest.[2] The average fiber diameter is in the region of 10μm; around 3% of fibres are extra-large (20μm) and arise from Betz cells, mostly in the leg area of the primary motor cortex.
The neuronal cell bodies in the motor cortex, together with their axons that travel down through the brain stem and spinal cord are commonly referred to as upper motor neurons.
Decussation and synapses[edit]
Some of the neuronal cell bodies in the motor cortex send long axons to the motor cranial nerve nuclei mainly of the contralateral side of the midbrain (cortico-mesencephalic tract), pons (Corticopontine tract), and medulla oblongata (cortico-bulbar tract), decussating just before they reach their target nuclei. These are called geniculate fibers. Many more motor cortex neurons, however, extend fibers all the way down to the spinal cord (corticospinal tract).
- Most of the corticospinal fibers (about 80%) cross over to the contralateral side in the medulla oblongata (pyramidal decussation). Those that cross in the medulla oblongata travel in the lateral corticospinal tract.[citation needed]
- 10% Enter the lateral corticospinal tract on the same side.
- The remainder of them (10%) travel in the anterior corticospinal tract. The majority of fibers from this tract cross over near the level that they exit the spinal cord, however a small portion will synapse in the anterior horn on the ipsilateral side.[citation needed]
Whichever of these two tracts it travels in, a corticospinal axon will synapse with another neuron in the ventral horn[citation needed]. This ventral horn neuron is considered a second-order neuron in this pathway, but is not part of the corticospinal tract itself.
From cerebral to motor neurons[edit]
The motor axons move closer together as they travel down through the cerebral white matter, and form part of the posterior limb of the internal capsule.
The motor fibers continue down into the brainstem. The bundle of corticospinal axons is visible as two column-like structures ("pyramids") on the ventral surface of medulla oblongata. However, the name pyramidal tract comes from the pyramidal/conical shape of the neuron cell bodies (soma) that comprise it.
After the decussation, the axons travel down the spinal cord as the lateral corticospinal tract. Fibers that do not cross over in the medulla oblongata travel down the separate anterior corticospinal tract, and most of them cross over to the contralateral side in the spinal cord, shortly before reaching the lower motor neurons.
Horizontal section through the lower part of the pons, showing the fibers of the corticospinal tract (#19) passing through the pontine nuclei
Lower motor neurons[edit]
In the spinal cord, the axons of the upper motor neuron connect (most of them via interneurons, but to a lesser extent also via direct synapses) with the lower motor neurons, located in the ventral horn of the spinal cord.
In the brain stem, the lower motor neurons are located in the motor cranial nerve nuclei (oculomotor, trochlear, motor nucleus of the trigeminal nerve, abducens, facial nerve, accessory, hypoglossal). The lower motor neuron axons leave the brain stem via motor cranial nerves and the spinal cord via anterior roots of the spinal nerves, respectively, ending up at the neuromuscular plate and providing motor innervation for voluntary muscles.
Sensory[edit]
- Spinothalamic tract
- Spinocerebellar tract
- Visual pathway
- Olfactory system
- Posterior column pathway
Neurons[edit]
The neurons of the these tracts are referred to as pyramidal tract neurons (PTN), because their axons form part of the pyramidal tracts leading to the spinal cord (or the cranial nerve nuclei with the corticobulbar tract), which in turn are named such because in cross-section they resemble pyramids as they pass through the medulla.[3]
Pyramidal tract neurons, however, are not to be confused with pyramidal neurons: a super-class of neurons, found in many parts of the brain including the cerebral cortex and the hippocampus, whose name derives from the pyramid-like shape of the cell body (soma). In fact, corticospinal neurons are both pyramidal tract neurons (because their axons pass through the medullary pyramids) and pyramidal neurons (because their cell body is shaped like a pyramid).
[edit]
See also: extrapyramidal motor system
These are motor pathways that lie outside the corticospinal tract and are beyond voluntary control. Their main function is to support voluntary movement and help control posture and muscle tone.
Function[edit]
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This section requires expansion. (March 2014) |
Clinical significance[edit]
Damage[edit]
Damage to the descending motor pathways anywhere along the trajectory from the cerebral cortex to the lower end of the spinal cord gives rise to a set of symptoms called the "Upper Motor Neuron Syndrome". A few days after the injury to the upper motor neurons, a pattern of motor signs and symptoms appears, including spasticity, the decreased vigor (and increased threshold) of superficial reflexes, a loss of the ability to perform fine movements, and an extensor plantar response known as the Babinski sign.[4]
Additional images[edit]
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Dissection of brain-stem. Lateral view.
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Superficial dissection of brain-stem. Ventral view.
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Diagram of the principal fasciculi of the spinal cord, from Gray's anatomy
References[edit]
- ^ Chapter 9 of "Principles of Physiology" (3rd edition) by Robert M. Berne and Mathew N. Levy. Published by Mosby, Inc. (2000) ISBN 0-323-00813-5.
- ^ page 239, origins of corticospinal & corticubulbar tracts, Ganongs Medical Review of Physiology 24th edition, ISBN 978-1-259-00962-4
- ^ The Brain From Top To Bottom
- ^ http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=neurosci&part=A1191
External links[edit]
- 959774759 at GPnotebook
- Brainstem at UWisc 01Pyramid
- McGill
- Stained brain slice images which include the "Corticospinal tract" at the BrainMaps project
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Human brain: mesencephalon (midbrain) (TA A14.1.06, GA 9.800)
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Tectum
(Dorsal) |
| Surface |
- Corpora quadrigemina: Inferior colliculi
- Brachium of inferior colliculus
- Superior colliculi
- Brachium of superior colliculus
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| Grey matter |
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| White: Sensory/ascending |
- Spinotectal tract
- Central tegmental tract
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| White: Motor/descending |
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Peduncle
(Ventral) |
| Tegmentum |
| White: Sensory/ascending |
- lemnisci
- Ascending MLF
- Vestibulo-oculomotor fibers
- Spinothalamic tract
- Anterior trigeminothalamic tract
- Dentatothalamic tract
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| White: Motor/descending |
- Rubrospinal tract
- Rubro-olivary tract
- Descending MLF
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| Grey: cranial nuclei |
- GSA
- V: Mesencephalic- GSE
- III: Oculomotor, IV: Trochlear- GVE
- III: Edinger–Westphal
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| Grey: other |
- Periaqueductal gray/Raphe nuclei
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- Ventral tegmental area
- Pedunculopontine nucleus
- Red nucleus
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| Ventricular system |
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| Base |
| White: Motor/descending |
- Cerebral crus: Corticospinal tract
- Corticobulbar tract
- Corticopontine tract/Frontopontine fibers/Temporopontine fibers
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| Grey: Substantia nigra |
- Pars compacta
- Pars reticulata
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| Surface |
- Superior cerebellar peduncle
- Decussation of superior cerebellar peduncles
- Interpeduncular fossa
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Human brain, rhombencephalon, metencephalon: pons (TA A14.1.05.101–604, GA 9.785)
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Dorsal/
(tegmentum) |
| Surface |
- Cerebellopontine angle
- Superior medullary velum
- Sulcus limitans
- Medial eminence
- Facial colliculus
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| White: Sensory/ascending |
- Trapezoid body/VIII
- Trigeminal lemniscus
- Dorsal trigeminal tract
- Ventral trigeminal tract
- Medial lemniscus
- Lateral lemniscus
- MLF, III, IV and VI: Vestibulo-oculomotor fibers
- Anterior trigeminothalamic tract
- Central tegmental tract
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| White: Motor/descending |
- ICP
- Vestibulocerebellar tract
- MLF, III, IV and VI: Vestibulospinal tract
- Medial vestibulospinal tract
- Lateral vestibulospinal tract
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| Grey: Cranial nuclei |
| afferent: |
- GSA: Principal V/Spinal V
- VIII-c
- VIII-v
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| efferent: |
- SVE: Motor V
- VII
- GSE: VI
- GVE: VII: Superior salivary nucleus
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| Other grey |
- Apneustic center
- Pneumotaxic center
- Medial parabrachial nucleus
- Lateral parabrachial nucleus
- Superior olivary nucleus
- Caerulean nucleus
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Ventral/
(base) |
| Grey |
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| White: Motor/descending |
- Corticospinal tract
- Corticobulbar tract
- Corticopontine fibers
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| Surface |
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Other grey: Raphe/
reticular |
- Reticular formation
- Caudal
- Oral
- Tegmental
- Paramedian
- Raphe nuclei
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Anatomy of torso (primarily): the spinal cord (TA 14.1.02, GA 9.749)
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| External, dorsal |
- Posterior median sulcus
- Posterolateral sulcus
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Grey matter/
Rexed laminae |
| I–VI: Posterior horn |
- I: Marginal nucleus
- II: Substantia gelatinosa of Rolando
- III+IV: Nucleus proprius
- Spinal lamina V
- Spinal lamina VI
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| VII: Lateral horn |
- Intermediolateral nucleus
- Posterior thoracic nucleus
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| VIII–IX: Anterior horn |
- Interneuron
- Alpha motor neuron
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| X: Other |
- Central gelatinous substance
- Gray commissure
- Central canal
- Terminal ventricle
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| White matter |
somatic/
ascending
(blue) |
| Posterior/PCML: |
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| Lateral: |
- proprioception: Spinocerebellar
- pain/temp: Spinothalamic
- Posterolateral (Lissauer)
- Spinotectal
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- Spinoreticular tract
- Spino-olivary tract
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motor/
descending
(red) |
| Lateral: |
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| Anterior: |
- Corticospinal
- Ep
- Vestibulospinal
- Reticulospinal
- Tectospinal
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| both |
- Anterior white commissure
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| External, ventral |
- Anterior median fissure
- Anterolateral sulcus
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| External, general |
- Cervical enlargement
- Lumbar enlargement
- Conus medullaris
- Filum terminale
- Cauda equina
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Brain and spinal cord: neural tracts and fasciculi
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Sensory/
ascending |
| PCML |
| 1°: |
- Pacinian corpuscle/Meissner's corpuscle → Posterior column (Gracile fasciculus/Cuneate fasciculus) → Gracile nucleus/Cuneate nucleus
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| 2°: |
- → sensory decussation/arcuate fibers (Posterior external arcuate fibers, Internal arcuate fibers) → Medial lemniscus/Trigeminal lemniscus → Thalamus (VPL, VPM)
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| 3°: |
- → Posterior limb of internal capsule → Postcentral gyrus
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Anterolateral/
pain |
| Fast/lateral |
- 1° (Free nerve ending → A delta fiber) → 2° (Anterior white commissure → Lateral and Anterior Spinothalamic tract → Spinal lemniscus → VPL of Thalamus) → 3° (Postcentral gyrus) → 4° (Posterior parietal cortex)
2° (Spinotectal tract → Superior colliculus of Midbrain tectum)
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| Slow/medial |
- 1° (Group C nerve fiber → Spinoreticular tract → Reticular formation) → 2° (MD of Thalamus) → 3° (Cingulate cortex)
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Motor/
descending |
| Pyramidal |
- flexion: Primary motor cortex → Posterior limb of internal capsule → Decussation of pyramids → Corticospinal tract (Lateral, Anterior) → Neuromuscular junction
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| Extrapyramidal |
| flexion: |
- Primary motor cortex → Genu of internal capsule → Corticobulbar tract → Facial motor nucleus → Facial muscles
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| flexion: |
- Red nucleus → Rubrospinal tract
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| extension: |
- Vestibulocerebellum → Vestibular nuclei → Vestibulospinal tract
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| extension: |
- Vestibulocerebellum → Reticular formation → Reticulospinal tract
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- Midbrain tectum → Tectospinal tract → muscles of neck
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| Basal ganglia |
| direct: |
1° (Motor cortex → Striatum) → 2° (GPi) → 3° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 4° (Thalamocortical radiations → Supplementary motor area) → 5° (Motor cortex)
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| indirect: |
1° (Motor cortex → Striatum) → 2° (GPe) → 3° (Subthalamic fasciculus → Subthalamic nucleus) → 4° (Subthalamic fasciculus → GPi) → 5° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 6° (Thalamocortical radiations → Supplementary motor area) → 7° (Motor cortex)
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| nigrostriatal pathway: |
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| Cerebellar |
| Afferent |
- Vestibular nuclei → Vestibulocerebellar tract → ICP → Cerebellum → Granule cell
- Pontine nuclei → Pontocerebellar fibers → MCP → Deep cerebellar nuclei → Granule cell
- Inferior olivary nucleus → Olivocerebellar tract → ICP → Hemisphere → Purkinje cell → Deep cerebellar nuclei
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| Efferent |
- Dentate nucleus in Lateral hemisphere/pontocerebellum → SCP → Dentatothalamic tract → Thalamus (VL) → Motor cortex
- Interposed nucleus in Intermediate hemisphere/spinocerebellum → SCP → Reticular formation, or → Cerebellothalamic tract → Red nucleus → Thalamus (VL) → Motor cortex
- Fastigial nucleus in Flocculonodular lobe/vestibulocerebellum → Vestibulocerebellar tract → Vestibular nuclei
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Bidirectional:
Spinocerebellar |
Unconscious
proprioception |
- lower limb → 1° (muscle spindles → DRG) → 2° (Posterior thoracic nucleus → Dorsal/posterior spinocerebellar tract → ICP → Cerebellar vermis)
- upper limb → 1° (muscle spindles → DRG) → 2° (Accessory cuneate nucleus → Cuneocerebellar tract → ICP → Anterior lobe of cerebellum)
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| Reflex arc |
- lower limb → 1° (Golgi tendon organ) → 2° (Ventral/anterior spinocerebellar tract→ SCP → Cerebellar vermis)
- upper limb → 1° (Golgi tendon organ) → 2° (Rostral spinocerebellar tract → ICP → Cerebellum)
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