肺サーファクタントタンパク質D

WordNet

having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 4th letter of the Roman alphabet (同)d

PrepTutorEJDIC

〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
蛋白(たんばく)質
deuteriumの化学記号
(おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
肺の;肺を冒す

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1. サーファクタント機能障害の遺伝性疾患 genetic disorders of surfactant dysfunction
2. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
3. 成人における肺胞蛋白症の臨床症状および病因 clinical manifestations and etiology of pulmonary alveolar proteinosis in adults
4. 間質性肺疾患を有する幼児および小児に対するアプローチ approach to the infant and child with interstitial lung disease
5. 新生児における呼吸促迫症候群の病態生理および臨床症状 pathophysiology and clinical manifestations of respiratory distress syndrome in the newborn

English Journal

Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.

Holmer SM1, Evans KS, Asfaw YG, Saini D, Schell WA, Ledford JG, Frothingham R, Wright JR, Sempowski GD, Perfect JR.Author information 1Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.AbstractCryptococcus neoformans is an opportunistic fungal pathogen that initiates infection following inhalation. As a result, the pulmonary immune response provides a first line of defense against C. neoformans. Surfactant protein D (SP-D) is an important regulator of pulmonary immune responses and is typically host protective against bacterial and viral respiratory infections. However, SP-D is not protective against C. neoformans. This is evidenced by previous work from our laboratory demonstrating that SP-D-deficient mice infected with C. neoformans have a lower fungal burden and live longer than wild-type (WT) control animals. We hypothesized that SP-D alters susceptibility to C. neoformans by dysregulating the innate pulmonary immune response following infection. Thus, inflammatory cells and cytokines were compared in the bronchoalveolar lavage fluid from WT and SP-D(-/-) mice after C. neoformans infection. Postinfection, mice lacking SP-D have reduced eosinophil infiltration and interleukin-5 (IL-5) in lung lavage fluid. To further explore the interplay of SP-D, eosinophils, and IL-5, mice expressing altered levels of eosinophils and/or IL-5 were infected with C. neoformans to assess the role of these innate immune mediators. IL-5-overexpressing mice have increased pulmonary eosinophilia and are more susceptible to C. neoformans infection than WT mice. Furthermore, susceptibility of SP-D(-/-) mice to C. neoformans infection could be restored to the level of WT mice by increasing IL-5 and eosinophils by crossing the IL-5-overexpressing mice with SP-D(-/-) mice. Together, these studies support the conclusion that SP-D increases susceptibility to C. neoformans infection by promoting C. neoformans-driven pulmonary IL-5 and eosinophil infiltration.
Infection and immunity.Infect Immun.2014 Feb;82(2):683-93. doi: 10.1128/IAI.00855-13. Epub 2013 Nov 25.
Cryptococcus neoformans is an opportunistic fungal pathogen that initiates infection following inhalation. As a result, the pulmonary immune response provides a first line of defense against C. neoformans. Surfactant protein D (SP-D) is an important regulator of pulmonary immune responses and is typ
PMID 24478083

Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms.

Horimasu Y, Hattori N1, Ishikawa N, Tanaka S, Bonella F, Ohshimo S, Guzman J, Costabel U, Kohno N.Author information 1Department of Molecular and Internal Medicine, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. nhattori@hiroshima-u.ac.jp.AbstractBACKGROUND: Surfactant protein A (SP-A) and SP-D are clinically established in Japan as serum biomarkers for diagnosing interstitial lung diseases (ILDs). Serum SP-D levels are affected by genetic variants. We conducted the present study to examine whether serum SP-A and/or SP-D levels in healthy subjects (HS) and patients with ILDs differ between populations with different genetic backgrounds.
BMC medical genetics.BMC Med Genet.2014 Jan 8;15:4. doi: 10.1186/1471-2350-15-4.
BACKGROUND: Surfactant protein A (SP-A) and SP-D are clinically established in Japan as serum biomarkers for diagnosing interstitial lung diseases (ILDs). Serum SP-D levels are affected by genetic variants. We conducted the present study to examine whether serum SP-A and/or SP-D levels in healthy su
PMID 24400879

Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis.

Kotecha S1, Doull I, Davies P, McKenzie Z, Madsen J, Clark HW, McGreal EP.Author information 1Department of Child Health, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.AbstractPulmonary surfactant protein-D (SP-D) is a soluble collagenous C-type lectin with important anti-microbial and anti-inflammatory properties. Although it is subject to functionally relevant modification by common polymorphisms and unregulated inflammation, the functional status of SP-D in cystic fibrosis (CF) remains unclear. Given the importance of infection and inflammation in CF lung pathology we have undertaken the first systematic analysis of SP-D lectin activity in this population. By ELISA, we found that airway lavage fluid SP-D expression was greater in CF compared to control patients but was reduced in CF patients with infection and correlated negatively with markers of neutrophilic inflammation. In a functional assay, the percentage of SP-D capable of binding zymosan rarely exceeded 60% in CF or control patients and similarly restricted binding activity was observed towards maltose-agarose. SP-D lectin activity also correlated negatively with infection and neutrophilic inflammation but there was little evidence of major proteolytic degradation amongst the non-bound material. SP-D which failed to bind zymosan exhibited features of lower oligomeric form compared to bound material when tested by native gel electrophoresis. Furthermore, when separated by gel chromatography, high and low oligomeric populations of SP-D were observed in CF lavage fluid but only high oligomeric forms exhibited substantial lectin activity towards yeast derived mannan. Our data demonstrate that oligomeric heterogeneity underlies functional diversity amongst SP-D in health and disease and that dynamic regulation of oligomerisation is an important feature of SP-D biology.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1832(12):2391-400. doi: 10.1016/j.bbadis.2013.10.002. Epub 2013 Oct 9.
Pulmonary surfactant protein-D (SP-D) is a soluble collagenous C-type lectin with important anti-microbial and anti-inflammatory properties. Although it is subject to functionally relevant modification by common polymorphisms and unregulated inflammation, the functional status of SP-D in cystic fibr
PMID 24120837

Japanese Journal

肺腺癌細胞の分泌蛋白質群‐外科的切除組織の培養上清に含まれる診断バイオマーカー候補の同定‐

果然,平野隆,川上隆雄,ごん雲波,野村将春,山口学,佐治久,垣花昌俊,大平達夫,池田徳彦
肺癌 50(2), 141-150, 2010
… 均蛍光強度比が2.0以上を示した（p<0.05）．質量分析を含む解析手順により34スポットのすべてから有意な蛋白質同定結果を得た．同定された蛋白質には，napsin Aやpulmonary surfactant-associated protein Aなど，II型肺胞上皮細胞への組織学的分化を示す蛋白質が含まれていた．また，腫瘍組織全般に共通して発現の亢進することが示唆される蛋白質も同定された．結 …
NAID 130000252348

Postmortem serum levels of pulmonary surfactant-associated proteins A and D with regard to the cause of death in medicolegal autopsy

QUAN Li,ZHU Bao-Li,ISHIKAWA Takaki,MICHIUE Tomomi,ZHAO Dong,YOSHIDA Chiemi,CHEN Jian-Hua,WANG Qi,KOMATSU Ayumi,AZUMA Yoko,MAEDA Hitoshi
Legal medicine 11, 301, 2009-04-01
NAID 10027262989

Pulmonary surfactant-associated protein A as a marker of respiratory distress in forensic pathology : assessment of the immunohistochemical and biochemical findings