pulmonary surfactant-associated protein C

• 肺サーファクタントタンパク質C

WordNet

1. having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
2. a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
3. a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
4. any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
5. make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
6. the 3rd letter of the Roman alphabet (同)c
7. (music) the keynote of the scale of C major
8. a general-purpose programing language closely associated with the UNIX operating system
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
2. carbonの化学記号
3. 蛋白(たんばく)質
4. 肺の;肺を冒す
5. cesiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/27 11:24:34」(JST)

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Surfactant protein C
PDB rendering based on 1spf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YAD
Identifiers
Symbols	SFTPC ; BRICD6; PSP-C; SFTP2; SMDP2; SP-C
External IDs	OMIM: 178620 MGI: 109517 HomoloGene: 2271 GeneCards: SFTPC Gene
Gene ontology Molecular function • protein binding • protein homodimerization activity Cellular component • extracellular space • multivesicular body • alveolar lamellar body Biological process • respiratory gaseous exchange • circadian rhythm • response to glucose • response to lipopolysaccharide • response to retinoic acid • response to vitamin A • protein homooligomerization • response to glucocorticoid • response to cAMP • response to hyperoxia • response to interleukin-6 • response to growth factor • cellular response to mechanical stimulus • cellular response to nitric oxide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6440	20389
Ensembl	ENSG00000168484	ENSMUSG00000022097
UniProt	P11686	Q6P8P8
RefSeq (mRNA)	NM_001172357	NM_011359
RefSeq (protein)	NP_001165828	NP_035489
Location (UCSC)	Chr 8: 22.16 – 22.16 Mb	Chr 14: 70.52 – 70.52 Mb
PubMed search	[1]	[2]

Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene.

It is a membrane protein which manufactures surfactant.

Clinical significance

It is associated with Surfactant metabolism dysfunction type 2.

Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.

See also

• Pulmonary_surfactant#Proteins

References

Further reading

• Pérez-Gil J (2002). "Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics". Pediatric pathology & molecular medicine 20 (6): 445–69. doi:10.1080/15227950152625783. PMID 11699574. 
• Solarin KO, Wang WJ, Beers MF (2002). "Synthesis and post-translational processing of surfactant protein C". Pediatric pathology & molecular medicine 20 (6): 471–500. doi:10.1080/15227950152625792. PMID 11699575. 
• Johansson J, Curstedt T, Robertson B (2002). "Artificial surfactants based on analogues of SP-B and SP-C". Pediatric pathology & molecular medicine 20 (6): 501–18. doi:10.1080/15227950152625800. PMID 11699576. 
• Nogee LM (2004). "Alterations in SP-B and SP-C expression in neonatal lung disease". Annu. Rev. Physiol. 66: 601–23. doi:10.1146/annurev.physiol.66.032102.134711. PMID 14977415. 
• Brasch F; Griese M; Tredano M et al. (2005). "Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene". Eur. Respir. J. 24 (1): 30–9. doi:10.1183/09031936.04.00000104. PMID 15293602. 
• Curstedt T; Johansson J; Persson P et al. (1990). "Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups". Proc. Natl. Acad. Sci. U.S.A. 87 (8): 2985–9. doi:10.1073/pnas.87.8.2985. PMC 53818. PMID 2326260. 
• Simatos GA, Forward KB, Morrow MR, Keough KM (1990). "Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C". Biochemistry 29 (24): 5807–14. doi:10.1021/bi00476a023. PMID 2383558. 
• Glasser SW; Korfhagen TR; Perme CM et al. (1988). "Two SP-C genes encoding human pulmonary surfactant proteolipid". J. Biol. Chem. 263 (21): 10326–31. PMID 2839484. 
• Glasser SW; Korfhagen TR; Weaver TE et al. (1988). "cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)". J. Biol. Chem. 263 (1): 9–12. PMID 3335510. 
• Johansson J; Jörnvall H; Eklund A et al. (1988). "Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms". FEBS Lett. 232 (1): 61–4. doi:10.1016/0014-5793(88)80386-7. PMID 3366248. 
• Warr RG; Hawgood S; Buckley DI et al. (1987). "Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7915–9. doi:10.1073/pnas.84.22.7915. PMC 299446. PMID 3479771. 
• Young WA (1966). "Familial fibrocystic pulmonary dysplasia: a new case in a known affected family". Canadian Medical Association journal 94 (20): 1059–61. PMC 1935417. PMID 5942662. 
• Wood S; Yaremko ML; Schertzer M et al. (1995). "Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas". Genomics 24 (3): 597–600. doi:10.1006/geno.1994.1673. PMID 7713515. 
• Hatzis D, Deiter G, deMello DE, Floros J (1994). "Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species". Exp. Lung Res. 20 (1): 57–72. doi:10.3109/01902149409064373. PMID 8181452. 
• Nogee LM; Dunbar AE; Wert SE et al. (2001). "A mutation in the surfactant protein C gene associated with familial interstitial lung disease". N. Engl. J. Med. 344 (8): 573–9. doi:10.1056/NEJM200102223440805. PMID 11207353. 
• Glasser SW; Burhans MS; Korfhagen TR et al. (2001). "Altered stability of pulmonary surfactant in SP-C-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6366–71. doi:10.1073/pnas.101500298. PMC 33474. PMID 11344267. 

External links

• GeneReviews/NIH/NCBI/UW entry on Pulmonary Fibrosis, Familial
• Pulmonary Surfactant-Associated Protein B at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. サーファクタント機能障害の遺伝性疾患 genetic disorders of surfactant dysfunction
• 2. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
• 3. 幼児および小児における間質性肺疾患分類 classification of interstitial lung disease in infants and children
• 4. 特発性肺線維症の病因 pathogenesis of idiopathic pulmonary fibrosis

English Journal

• SFTPC mutations in patients with familial pulmonary fibrosis: combined with emphysema?

• Cottin V, Cordier JF.
• American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2011 Apr 15;183(8):1113; author reply 1113-4.
• PMID 21498825

• Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury.

• Spragg RG, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Gunther A.SourceVeterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. rspragg@ucsd.edu
• American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2011 Apr 15;183(8):1055-61. Epub 2010 Dec 10.
• RATIONALE: Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of p
• PMID 21148720

Japanese Journal

• 肺腺癌細胞の分泌蛋白質群―外科的切除組織の培養上清に含まれる診断バイオマーカー候補の同定―

• 果 然,平野 隆,川上 隆雄,ごん 雲波,野村 将春,山口 学,佐治 久,垣花 昌俊,大平 達夫,池田 徳彦
• 肺癌 50(2), 141-150, 2010
• … 均蛍光強度比が2.0以上を示した（p<0.05）．質量分析を含む解析手順により34スポットのすべてから有意な蛋白質同定結果を得た．同定された蛋白質には，napsin Aやpulmonary surfactant-associated protein Aなど，II型肺胞上皮細胞への組織学的分化を示す蛋白質が含まれていた．また，腫瘍組織全般に共通して発現の亢進することが示唆される蛋白質も同定された．結 …
• NAID 130000252348

• Postmortem serum levels of pulmonary surfactant-associated proteins A and D with regard to the cause of death in medicolegal autopsy

• QUAN Li,ZHU Bao-Li,ISHIKAWA Takaki,MICHIUE Tomomi,ZHAO Dong,YOSHIDA Chiemi,CHEN Jian-Hua,WANG Qi,KOMATSU Ayumi,AZUMA Yoko,MAEDA Hitoshi
• Legal medicine 11, 301, 2009-04-01
• NAID 10027262989

Related Links

• Pulmonary surfactant-associated protein C - Wikipedia, the free ...

Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene. Pulmonary surfactant-associated protein C is a membrane protein which manufactures surfactant. ...

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★リンクテーブル★

リンク元	「肺サーファクタントタンパク質C」
関連記事	「associate」「C」「associated」「pulmonary」「surfactant」

「肺サーファクタントタンパク質C」

　　[★]

英

pulmonary surfactant-associated protein C

「associate」

　　[★]

• vt.

• 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる

• vi.

• 仲間/友人などとして交際する(with)。一つにまとめる、連合する

• n.

• 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
• 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
• 連想によって心に浮かぶ言葉/思い、連想物

• adj.

• 仲間の、同僚の。製紙機械員に次ぐ資格の
• 付随する、連想される

関

accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union

　 　 　 　 　 　

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「associated」

　　[★]

• adj.

• 随伴の、随伴性の

関

concomitant、erratic、erratically

associate

「pulmonary」

　　[★]

• adj.

• 肺の、肺性の

関

lung、pneumo

　

「surfactant」

　　[★]

• n.

• 界面活性剤、サーファクタント