prostacyclin

プロスタグランジンI2 PC

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/23 03:09:33」(JST)

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English Journal

  • The pulmonary arterial hypertension quality enhancement research initiative: comparison of patients with idiopathic PAH to patients with systemic sclerosis-associated PAH.
  • Clements PJ, Tan M, McLaughlin VV, Oudiz RJ, Tapson VF, Channick RN, Rubin LJ, Langer A; on behalf of the Pulmonary Arterial Hypertension Quality Enhancement Research Initiative (PAH-QuERI)Investigators.SourceCorrespondence to Dr Philip J Clements, Department of Medicine, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Los Angeles, CA 90095, USA; pclements@mednet.ucla.edu.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2012 Feb;71(2):249-252. Epub 2011 Oct 13.
  • OBJECTIVE: The objective of this report is to compare baseline, management and survival characteristics in idiopathic pulmonary arterial hypertension (IPAH) with systemic sclerosis-associated pulmonary arterial hypertension (SSc-APAH) using data from the prospectively enrolled PAH Quality Enhancemen
  • PMID 21998119
  • Endothelial hyperpolarizing factor increases acetylcholine-induced vasodilatation in pulmonary hypertensive broilers arterial rings.
  • Alvarez-Medina DI, Hernandez A, Orozco C.SourceDirectora Unidad Municipal de Asistencia Técnica Agropecuaria, La Palma, Cundinamarca, Colombia.
  • Research in veterinary science.Res Vet Sci.2012 Feb;92(1):1-6. Epub 2011 Mar 5.
  • Pulmonary arterial hypertension (PAH) develops as result of imbalances between endothelium derived vasoconstrictors and vasodilators. Pulmonary hypertensive broiler chickens (PHBs) are deficient in NO production and endothelin-1 (ET-1) excess. With respect to prostacyclin, it appears that it does no
  • PMID 21382630

Japanese Journal

  • ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells
  • Watatani Hiroyuki,Yamasaki Hiroko,Maeshima Yohei,Nasu Tatsuyo,Hinamoto Norikazu,Ujike Haruyo,Sugiyama Hitoshi,Sakai Yoshiki,Tanabe Katsuyuki,Makino Hirofumi
  • Acta Medica Okayama 69(1), 1-15, 2015-02
  • … ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. … In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. …
  • NAID 120005549937
  • Effects of beraprost sodium, an oral prostacyclin analog, on insulin resistance in patients with type 2 diabetes
  • Katsuyama Hisayuki,Kubota Naoto,Kubota Tetsuya [他]
  • Diabetology international 6(1), 39-45, 2015
  • NAID 40020406077
  • Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats
  • Wang Yun,Cao Shao-Hua,Cui Ying-Jie,Kong Le-Kai,Tian Hua,Cai Hong-Xin,Wu Ya-Ping,Han Ji-Ju,Zhao Xiao-Min,Xia Zuo-Li
  • The Tohoku Journal of Experimental Medicine 236(2), 155-162, 2015
  • … Measurement of biochemical parameters indicated that AESM decreased endothelin-1 and thromboxane A2 in plasma and increased nitrogen monoxide and prostacyclin in the plasma and reduced the increase of transforming growth factor β1 in lung tissue. …
  • NAID 130005075698

Related Links

prostacyclin [pros″tah-si´klin] a prostaglandin, PGI 2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol
Prostacyclinとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Prostacyclinとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...


Related Pictures

Prostacyclin synthaseDescription Prostacyclin synthase 2IAG.pngCerebral autoregulation may be quite Eicosanoid synthesis.Prostacyclin Pathwaycalcium channel blockers mechanism of



★リンクテーブル★
リンク元血管内皮」「プロスタグランジンI2」「PC」「エポプロステノール」「prostaglandin I
拡張検索prostacyclin receptor

血管内皮」

  [★]

endothelium (Z)
血管


Table 10-1. Endothelial Cell Properties and Functions
Maintenance of Permeability Barrier
Elaboration of Anticoagulant, Antithrombotic, Fibrinolytic Regulators
prostacyclin
thrombomodulin
heparin-like molecules
plasminogen activator
Elaboration of Prothrombotic Molecules
Von Willebrand factor
Tissue factor
Plasminogen activator inhibitor
Extracellular Matrix Production (Collagen, Proteoglycans)
Modulation of Blood Flow and Vascular Reactivity
Vasconstrictors: endothelin, ACE
Vasodilators: NO, prostacyclin
Regulation of Inflammation and Immunity
IL-1, IL-6, chemokines
Adhesion molecules: VCAM-1, ICAM, E-selectin P-selectin
Histocompatibility antigens
Regulation of Cell Growth
Growth stimulators: PDGF, CSF, FGF
Growth inhibitors: heparin, TGF-β
Oxidation of LDL

プロスタグランジンI2」

  [★]

prostaglandin I2PGI2
プロスタサイクリンprostacyclin
PGH2TXA2NSAIDs


代謝

プロスタグランジンH2-(PGI synthase)→プロスタグランジンI2

生理作用

  • 血管拡張 (SPC.108)
  • 血小板凝集抑制 (SPC.108)
  • 血小板凝集抑制作用 (SPC.285)
PGI2:PGD2:PGE1=40:4:1
PGI1とPGE1はIP受容体、PGD2はDP受容体に結合→AC↑→[cAMP]i↑→血小板凝集抑制

炎症

  • 炎症を発展する方向に作用 → 血漿滲出増強

PC」

  [★]

 

エポプロステノール」

  [★]

epoprostenol
エポプロステノールナトリウム epoprostenol sodium
フローラン
プロスタサイクリン prostacyclinプロスタグランジンI2 prostaglandin I2 PGI2
肺高血圧

prostaglandin I」

  [★]

プロスタグランジンI

prostacyclin

prostacyclin receptor」

  [★]

epoprostenol receptorPGI2 receptorprostaglandin I2 receptor