prostacyclin receptor

• プロスタサイクリン受容体、プロスタサイクリンレセプター

関

epoprostenol receptor、PGI2 receptor、prostaglandin I2 receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/10 15:17:16」(JST)

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Prostaglandin I2 (prostacyclin) receptor (IP)
Identifiers
Symbols	PTGIR ; IP; PRIPR
External IDs	OMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: 345 ChEMBL: 1995 GeneCards: PTGIR Gene
Gene ontology Molecular function • G-protein coupled receptor activity • guanyl-nucleotide exchange factor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cell-cell signaling • blood coagulation • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of cAMP biosynthetic process • response to lipopolysaccharide • positive regulation of GTPase activity • positive regulation of cAMP-mediated signaling • negative regulation of smooth muscle cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5739	19222
Ensembl	ENSG00000160013	ENSMUSG00000043017
UniProt	P43119	P43252
RefSeq (mRNA)	NM_000960	NM_008967
RefSeq (protein)	NP_000951	NP_032993
Location (UCSC)	Chr 19: 46.62 – 46.63 Mb	Chr 7: 16.91 – 16.91 Mb
PubMed search	[1]	[2]

Prostacyclin receptor ( or prostaglandin I₂ receptor, IP₁) is a receptor for prostacyclin, encoded by the PTGIR gene.

It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.

There are actually two receptors for prostacyclin, the other being IP₂.

Transduction

When binding a prostacyclin-molecule, the receptor changes conformation and activates G_s, with its activation of cAMP and increase in protein kinase A (PKA) activity.

In vasodilation

In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.

Gene

The receptor is encoded by the human gene PTGIR.

See also

• Eicosanoid receptor

References

External links

• "Prostanoid Receptors: IP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
• Rauvala H, Peng HB (1997). "HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts". Prog. Neurobiol. 52 (2): 127–44. doi:10.1016/S0301-0082(97)00007-5. PMID 9185236. 
• Smyth EM, FitzGerald GA (2003). "Human prostacyclin receptor". Vitam. Horm. Vitamins & Hormones 65: 149–65. doi:10.1016/S0083-6729(02)65063-0. ISBN 978-0-12-709865-4. PMID 12481546. 
• Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). "Cloning and expression of a cDNA for the human prostanoid IP receptor". J. Biol. Chem. 269 (16): 12173–8. PMID 7512962. 
• Katsuyama M, Sugimoto Y, Namba T, et al. (1994). "Cloning and expression of a cDNA for the human prostacyclin receptor". FEBS Lett. 344 (1): 74–8. doi:10.1016/0014-5793(94)00355-6. PMID 7514139. 
• Ogawa Y, Tanaka I, Inoue M, et al. (1995). "Structural organization and chromosomal assignment of the human prostacyclin receptor gene". Genomics 27 (1): 142–8. doi:10.1006/geno.1995.1016. PMID 7665161. 
• Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114. 
• Nakagawa O, Tanaka I, Usui T, et al. (1994). "Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system". Circulation 90 (4): 1643–7. doi:10.1161/01.cir.90.4.1643. PMID 7923647. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Sasaki Y, Takahashi T, Tanaka I, et al. (1997). "Expression of prostacyclin receptor in human megakaryocytes". Blood 90 (3): 1039–46. PMID 9242534. 
• Fisch A, Tobusch K, Veit K, et al. (1997). "Prostacyclin receptor desensitization is a reversible phenomenon in human platelets". Circulation 96 (3): 756–60. doi:10.1161/01.cir.96.3.756. PMID 9264479. 
• Smyth EM, Li WH, FitzGerald GA (1998). "Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c". J. Biol. Chem. 273 (36): 23258–66. doi:10.1074/jbc.273.36.23258. PMID 9722557. 
• Kömhoff M, Lesener B, Nakao K, et al. (1999). "Localization of the prostacyclin receptor in human kidney". Kidney Int. 54 (6): 1899–908. doi:10.1046/j.1523-1755.1998.00213.x. PMID 9853255. 
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129. 
• Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). "Internalization and sequestration of the human prostacyclin receptor". J. Biol. Chem. 275 (41): 32037–45. doi:10.1074/jbc.M003873200. PMID 10889200. 
• Lawler OA, Miggin SM, Kinsella BT (2001). "Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling". J. Biol. Chem. 276 (36): 33596–607. doi:10.1074/jbc.M104434200. PMID 11443126. 
• Zhang Z, Austin SC, Smyth EM (2001). "Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction". Mol. Pharmacol. 60 (3): 480–7. PMID 11502878. 
• Fortier I, Patry C, Lora M, et al. (2001). "Immunohistochemical localization of the prostacyclin receptor (IP) human bone". Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. doi:10.1054/plef.2001.0292. PMID 11545623. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Related Links

• Prostacyclin receptor - Wikipedia, the free encyclopedia

Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for prostacyclin. It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent ...

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★リンクテーブル★

リンク元	「PGI2 receptor」「prostaglandin I2 receptor」「プロスタサイクリン受容体」「epoprostenol receptor」「プロスタサイクリンレセプター」
関連記事	「prostacyclin」

「PGI2 receptor」

　　[★]

• プロスタグランジンI2受容体、プロスタグランジンI2レセプター、PGI2受容体、PGI2レセプター

関

epoprostenol receptor、prostacyclin receptor、prostaglandin I2 receptor

「prostaglandin I2 receptor」

　　[★]

• プロスタグランジンI2受容体、プロスタグランジンI2レセプター

関

epoprostenol receptor、PGI2 receptor、prostacyclin receptor

「プロスタサイクリン受容体」

　　[★]

英

prostacyclin receptor

関

エポプロステノール受容体、プロスタサイクリンレセプター、プロスタグランジンI2受容体

「epoprostenol receptor」

　　[★]

• エポプロステノール受容体

関

PGI2 receptor、prostacyclin receptor、prostaglandin I2 receptor

「プロスタサイクリンレセプター」

　　[★]

英

prostacyclin receptor

関

プロスタサイクリン受容体

「prostacyclin」

　　[★] プロスタグランジンI2 PC