- 低分化の
WordNet
- of or relating to anaplasia
- unsatisfactory; "a poor light for reading"; "poor morale"; "expectations were poor"
- characterized by or indicating poverty; "the country had a poor economy"; "they lived in the poor section of town"
- having little money or few possessions; "deplored the gap between rich and poor countries"; "the proverbial poor artist living in a garret"
- lacking in specific resources, qualities or substances; "a poor land"; "the area was poor in timber and coal"; "food poor in nutritive value"
- calculate a derivative; take the derivative
- become different during development; "cells differentiate"
- become distinct and acquire a different character
- made different (especially in the course of development) or shown to be different; "the differentiated markings of butterflies"; "the regionally differentiated results"
- exhibiting biological specialization; adapted during development to a specific function or environment
PrepTutorEJDIC
- 『貧乏な,貧しい』 / 『貧相な』,みすぼらしい / (一定規準よりも)劣る,落ちる / 《名詞の前にのみ用いて》哀れな,不運な,かわいそうな / 《名詞の前にのみ用いて》故人となった,なくなった / 《名詞の前にのみ用いて》《謙そん,またはおどけて》つまらない,取るに足らない / 《the~》《名詞的に》《複数扱い》貧しい人々;かわいそうな人々
- (…から)…‘を'『区別する』,識別する《+『名』+『from』+『名』》 / …‘を'微分する / (…を)区別をつける,(…を)識別する《+『between』+『名』》 / 別のものとなる
- 『貧しく』,乏しく,不十分に / 『へたに』,まずく / 健康がすぐれない,病身な
UpToDate Contents
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- 1. 原発不明の低分化癌 poorly differentiated carcinoma of unknown primary site
- 2. 原発不明の低分化腫瘍 poorly differentiated neoplasms of unknown primary site
- 3. 原発不明の腫瘍の分類および管理の概要 overview of the classification and management of neoplasms of unknown primary site
- 4. 転移性の胃腸膵管系神経内分泌腫瘍：腫瘍増殖およびホルモン過剰分泌による症状を管理
するための全身治療の選択肢 metastatic gastroenteropancreatic neuroendocrine tumors systemic therapy options to control tumor growth and symptoms of hormone hypersecretion - 5. 分化（レチノイン酸）症候群 differentiation retinoic acid syndrome
English Journal
- Cytoplasmic OCT4 staining is a sensitive marker of neuroendocrine differentiation.
- Alexander RE, Cheng L, Grignon DJ, Idrees MT.Author information Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: realexan@iupui.edu.AbstractPrevious studies by the authors have described a novel cytoplasmic staining pattern with OCT4 in normal adrenal medullary tissue and in paragangliomas. We aimed to determine if this type of staining is found in other neuroendocrine tissues by examining a broad range of neuroendocrine tumors. Fifty neuroendocrine tumors of various grades and primary organ sites were selected. All cases were immunostained with OCT4 and Ki-67. OCT4 reactivity was then scored for intensity (0-3+) and extent (0-3+). Ki-67 proliferation index was scored as a percentage of total tumor cells. Immunoelectron microscopy was performed to determine precise location of antibody binding within cells. Immunoreactivity was seen in 26 (96%) of 27 cases of carcinoid tumors. The same type of strong staining was seen in 4 (67%) of 6 moderately differentiated neuroendocrine tumors. Only 2 (12%) of 17 poorly differentiated neuroendocrine tumors showed similar staining. A strong, inverse correlation was seen with OCT4 and Ki-67 index. Immunoelectron microscopy showed binding of OCT4 antibody to neurosecretory granules. Cytoplasmic staining of OCT4 is a sensitive marker of neuroendocrine differentiation that has yet to be described in any other tissue or tumor type. These findings show that this antibody has a high affinity for well- to moderately differentiated neuroendocrine tumors. Although comparative studies with other markers and a more extensive analysis of other tissue types are necessary, cytoplasmic staining of OCT4 may prove to be a useful immunostain in the diagnosis of neuroendocrine tumors.
- Human pathology.Hum Pathol.2014 Jan;45(1):27-32. doi: 10.1016/j.humpath.2013.08.006. Epub 2013 Oct 30.
- Previous studies by the authors have described a novel cytoplasmic staining pattern with OCT4 in normal adrenal medullary tissue and in paragangliomas. We aimed to determine if this type of staining is found in other neuroendocrine tissues by examining a broad range of neuroendocrine tumors. Fifty n
- PMID 24182453
- Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma.
- Dambrauskas Z, Svensson H, Joshi M, Hyltander A, Naredi P, Iresjö BM.Author information Department of Surgery and Institute for Research of Digestive System, Lithuanian University of Health Sciences, Kaunas, Lithuania.AbstractMajor histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind to the immunoreceptor NKG2D and play an important role in mediating cytotoxicity of NK and T cells. Release of MIC molecules from the cell surface is thought to constitute an immune escape mechanism of tumor cells and thus could be associated with more aggressive course of tumor growth. In this study, we investigated the expression of MICA/B in ductal pancreatic carcinoma and serum in relation to tumor stage, differentiation and survival. MICA/B expression in tumor tissues and sera from patients with pancreatic cancer were analyzed by immunohistochemical staining (IHC), western blotting and ELISA, respectively. MICA/B expression was present in 17 of 22 (77%) of the tumors but not in normal pancreatic ductal epithelial cells. Poorly differentiated tumors showed more pronounced MICA/B expression compared to differentiated tumors, but did not correlate significantly to other tumor characteristics. MICA/B-negative tumors displayed significantly lower incidence of lymph node metastases (p<0.01), and less mortality within 3 years following resection (p<0.02). In conclusion, tissue levels of MICA/B expression were elevated in pancreatic cancer cells without elevated levels in serum, despite well-recognized acute phase reactants in serum. Poorly differentiated tumors showed high MICA/B expression, which was related to extended tumor lymph node metastases and less frequent long-term survival.
- International journal of oncology.Int J Oncol.2014 Jan;44(1):99-104. doi: 10.3892/ijo.2013.2156. Epub 2013 Oct 31.
- Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind to the immunoreceptor NKG2D and play an important role in mediating cytotoxicity of NK and T cells. Release of MIC molecules from the cell surface is thought to constitute an immune e
- PMID 24173243
- Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors.
- Brychtova V, Hermanova M, Karasek P, Lenz J, Selingerova I, Vojtesek B, Kala Z, Hrstka R.Author information From the *Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute; †First Department of Pathological Anatomy, St Anne's University Hospital, Medical Faculty of Masaryk University; ‡Department of Complex Oncology Care, Masaryk Memorial Cancer Institute; §Department of Mathematics and Statistics, Faculty of Science, Masaryk University; and ∥Department of Surgery, University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech Republic.AbstractOBJECTIVES: This study aimed to determine anterior gradient 2 (AGR2) expression in biopsies from pancreatic ductal adenocarcinomas (PDACs) and to evaluate AGR2 as a potential independent prognostic factor.
- Pancreas.Pancreas.2014 Jan;43(1):75-81. doi: 10.1097/MPA.0b013e3182a63bc3.
- OBJECTIVES: This study aimed to determine anterior gradient 2 (AGR2) expression in biopsies from pancreatic ductal adenocarcinomas (PDACs) and to evaluate AGR2 as a potential independent prognostic factor.METHODS: Tissue sample sections from a cohort of 135 consecutive surgically resectable PDACs we
- PMID 24177142
Japanese Journal
- Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential
- Murakami Hiroki,Nakanishi Hayao,Tanaka Harunari
- Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 16(1), 74-83, 2013
- NAID 40019557355
- 臨床報告 乳頭癌,好酸性細胞型濾胞癌,低分化癌が併存した甲状腺多発癌の1例
- 和久 利彦,勝部 亮一,大多和 泰幸
- 臨床外科 67(10), 1333-1337, 2012-10
- NAID 40019441237
- ストロンチウム89(Sr)により長期に病勢をコントロールできた去勢ドセタキセル抵抗性前立腺癌の1例
- 上山 裕樹,井口 亮,牧野 雄樹
- 泌尿器科紀要 58(9), 515-518, 2012-09
- … Prostate biopsy specimens revealed poorly differentiated adenocarcinoma, Gleason's score 5＋3. …
- NAID 40019429582
Related Links
- poorly differentiated Oncology adjective Referring to a malignancy in which the malignant cells bear minimal resemblance to the cell from which they arose. Cf Well-differentiated.
- Differentiated carcinoma facts are now available. Learn about poorly differentiated carcinoma, well differentiated carcinoma and all their different types. ... This article has the purpose to provide you information on what differentiated ...
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★リンクテーブル★
| リンク元 | 「anaplastic」「低分化」 |
| 関連記事 | 「differentiate」「poorly」「poor」「differentiated」 |
「anaplastic」
- 未分化の、低分化の、退形成の
- 同
- malignant astrocytoma, 退形成性悪性星状細胞腫
「低分化」
「differentiate」
- v.
- 分化する、鑑別する、区別する
- 関
- differentiation、differentiative、discriminate、discrimination、distinction、distinguish、specialization
「poorly」
- adv.
- 不十分に
「poor」
- adj.
- 乏しい
「differentiated」
- adj.
- 分化型の