胸腹裂孔ヘルニア
WordNet
- rupture in smooth muscle tissue through which a bodily structure protrudes (同)herniation
PrepTutorEJDIC
- ヘルニア,脱腸
UpToDate Contents
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English Journal
- Current concepts on the pathogenesis and etiology of congenital diaphragmatic hernia.
- Greer JJ.Author information Centre for Neuroscience, Department of Physiology, Women and Children's Health Research Institute, 3-020M Katz Building, University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address: John.Greer@ualberta.ca.AbstractThis review outlines research that has advanced our understanding of the pathogenesis and etiology of congenital diaphragmatic hernia (CDH). The majority of CDH cases involve incomplete formation of the posterolateral portion of the diaphragm, clinically referred to as a Bochdalek hernia. The hole in the diaphragm allows the abdominal viscera to invade the thoracic cavity, thereby impeding normal lung development. As a result, newborns with CDH suffer from a combination of severe pulmonary hypoplasia and pulmonary hypertension. Despite advances in neonatal intensive care, mortality and serious morbidity remain high. Systematic studies using rat and transgenic mouse models in conjunction with analyses of human tissue are providing insights into the embryological origins of the diaphragmatic defect associated with CDH and abnormalities of developmentally regulated signaling cascades.
- Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2013 Nov 1;189(2):232-40. doi: 10.1016/j.resp.2013.04.015. Epub 2013 May 9.
- This review outlines research that has advanced our understanding of the pathogenesis and etiology of congenital diaphragmatic hernia (CDH). The majority of CDH cases involve incomplete formation of the posterolateral portion of the diaphragm, clinically referred to as a Bochdalek hernia. The hole i
- PMID 23665522
- Decreased expression of GATA4 in the diaphragm of nitrofen-induced congenital diaphragmatic hernia.
- Dingemann J1, Doi T, Gosemann JH, Ruttenstock EM, Nakazawa N, Puri P.Author information 1National Children's Research Centre, Our Lady's Children's Hospital Dublin, and University College Dublin, Dublin, Ireland.AbstractBACKGROUND: The molecular mechanisms underlying the diaphragmatic defect in congenital diaphragmatic hernia (CDH) are still poorly understood. The transcription factor GATA4 is essential for normal development of the diaphragm. Recently, mutations in the GATA4 gene have been linked to human and rodent CDH. We hypothesized that diaphragmatic GATA4 expression is downregulated in the nitrofen CDH model.
- Birth defects research. Part B, Developmental and reproductive toxicology.Birth Defects Res B Dev Reprod Toxicol.2013 Apr;98(2):139-43. doi: 10.1002/bdrb.21037. Epub 2013 Feb 19.
- BACKGROUND: The molecular mechanisms underlying the diaphragmatic defect in congenital diaphragmatic hernia (CDH) are still poorly understood. The transcription factor GATA4 is essential for normal development of the diaphragm. Recently, mutations in the GATA4 gene have been linked to human and rode
- PMID 23426975
- Late-onset congenital diaphragmatic hernia: A case report.
- Vega MT1, Maldonado RH, Vega GT, Vega AT, Liévano EA, Velázquez PM.Author information 1Hospital General "Dr. Manuel Gea González", Departamento de Cirugía General, Calzada de Tlalpan 4800, Sección XVI, Tlalpan, zip code 14080 México City, Mexico.AbstractINTRODUCTION: A Bochdalek hernia is a posterior congenital defect of the diaphragm, usually on the left hemidiafragm, caused by a lack of closure of the pleuroperitoneal canal between the eighth and tenth week of fetal life during the embryonic development. It typically presents in the neonatal period with severe respiratory failure.
- International journal of surgery case reports.Int J Surg Case Rep.2013;4(11):952-4. doi: 10.1016/j.ijscr.2013.07.034. Epub 2013 Aug 28.
- INTRODUCTION: A Bochdalek hernia is a posterior congenital defect of the diaphragm, usually on the left hemidiafragm, caused by a lack of closure of the pleuroperitoneal canal between the eighth and tenth week of fetal life during the embryonic development. It typically presents in the neonatal peri
- PMID 24055915
Japanese Journal
- Congenital Diaphragmatic Hernia : Experimental Approach
- Pathogenesis of Congenital Diaphragmatic Hernia Induced by Transplacental Infusion of Bisdiamine into Rats
- Lung hypoplasia in developing mice and rats induced by maternal exposure to nitrofen
- 植木 礼子 [他],NAKAO Yoshitaka,NISHIDA Takuji,NAKAO Yasuko,WAKABAYASHI Takashi
- 先天異常 30(2), p133-143, 1990-06
- NAID 110002786178
Related Links
- Bochdalek hernia congenital diaphragmatic hernia through the pleuroperitoneal hiatus. cerebral hernia protrusion of brain substance through the cranium. Cloquet's hernia ...
- Pleuroperitoneal Diaphragmatic Hernia (Bochdalek´s Hernia) vs. Sternocostal Diaphragmatic Hernia (Foramen Morgagni Hernia) Pleuroperitoneal Diaphragmatic Hernia (Bochdalek´s Hernia) vs. Sternocostal Diaphragmatic Hernia ...
★リンクテーブル★
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- 英
- pleuroperitoneal diaphragmatic hernia
- 同
- 胸腹膜裂孔ヘルニア、ボホダレック孔ヘルニア Bochdalek孔ヘルニア Bochdalek hernia、ボホダレクヘルニア、Bochdalekヘルニア
- 関
- 先天性横隔膜ヘルニア、横隔膜ヘルニア、横隔膜
- 腰肋三角、ヘルニア
概念
- 胸腹裂孔の閉鎖障害により、ヘルニア門を通じて、腸管、脾臓、肝臓が胸腔に脱出する。左に多く(右2:左8)、ヘルニア嚢を欠く。
- 患側肺、時に両側肺の低形成を伴う。
- 治療成績は悪い
- 成人に至ってから発症するものもある（遅発型胸膜裂孔ヘルニア）
疫学
病因
病変形成＆病理
症状
合併奇形
診断
検査
治療
予後
- 出生後24時間以内に緊急手術が必要な症例では予後不良
- 生後24時間以降にまで手術を待機できるような症例は予後良好。
予防
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- 関
- diaphragm、diaphragma、interseptum