リン脂質輸送タンパク質, PLTP
WordNet
- move from one place to another; "transfer the data"; "transmit the news"; "transfer the patient to another hospital"
- the act of transfering something from one form to another; "the transfer of the music from record to tape suppressed much of the background noise" (同)transference
- transferring ownership (同)transference
- application of a skill learned in one situation to a different but similar situation (同)transfer of training, carry-over
- someone who transfers or is transferred from one position to another; "the best student was a transfer from LSU" (同)transferee
- a ticket that allows a passenger to change conveyances
- change from one vehicle or transportation line to another; "She changed in Chicago on her way to the East coast" (同)change
- transfer somebody to a different position or location of work (同)reassign
- move around; "transfer the packet from his trouser pockets to a pocket in his jacket" (同)shift
- transfer from one place or period to another; "The ancient Greek story was transplanted into Modern America" (同)transpose, transplant
- cause to change ownership; "I transferred my stock holdings to my children"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- any of various compounds composed of fatty acids and phosphoric acid and a nitrogenous base; an important constituent of membranes
PrepTutorEJDIC
- (…から…へ)〈人・物〉‘を'『移す』,移転させる,乗り換えさせる《+名〈人・物〉+from+名+to+名》 / (…から…へ)〈権利・財産など〉‘を'譲り渡す,移転する《+名〈権利・財産〉+from+名+to+名》 / 〈絵画・デザインなど〉‘を'写す,転写する / 〈人が〉(ある人・場所から他の人・場所などへ)『移る』,移される;転任する,転任させられる《+from+名+to+名》 / (…から…へ)列車(バスなど)を乗り換える《+from+名+to+名》 / 〈U〉〈C〉(…を)『移すこと』,(…が)移転されること《+of+名》;転任,転校 / 〈C〉移る人(物),移される人(物);転校生,転任者 / 〈C〉乗り換え切符 / 〈C〉乗り換え場所 / 〈C〉写し絵
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/24 14:09:12」(JST)
[Wiki en表示]
Phospholipid transfer protein |
Identifiers |
Symbols |
PLTP ; BPIFE; HDLCQ9 |
External IDs |
OMIM: 172425 MGI: 103151 HomoloGene: 4536 ChEMBL: 5962 GeneCards: PLTP Gene |
Gene ontology |
Molecular function |
• lipid binding
|
Cellular component |
• extracellular region
|
Biological process |
• lipid metabolic process
• lipid transport
• vitamin E biosynthetic process
• sperm motility
|
Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
5360 |
18830 |
|
Ensembl |
ENSG00000100979 |
ENSMUSG00000017754 |
|
UniProt |
P55058 |
P55065 |
|
RefSeq (mRNA) |
NM_001242920 |
NM_011125 |
|
RefSeq (protein) |
NP_001229849 |
NP_035255 |
|
Location (UCSC) |
Chr 20:
44.53 – 44.54 Mb |
Chr 2:
164.84 – 164.86 Mb |
|
PubMed search |
[1] |
[2] |
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Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.
Contents
- 1 Function
- 2 Interactions
- 3 Interactive pathway map
- 4 References
- 5 Further reading
Function
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[1]
Interactions
PLTP has been shown to interact with Apolipoprotein A1[2] and APOA2.[2]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
References
- ^ "Entrez Gene: PLTP phospholipid transfer protein".
- ^ a b Pussinen, P J; Jauhiainen M, Metso J, Pyle L E, Marcel Y L, Fidge N H, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. (UNITED STATES) 39 (1): 152–61. ISSN 0022-2275. PMID 9469594.
Further reading
- Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis.". Front. Biosci. 7: d1634–41. doi:10.2741/jiang1. PMID 12086920.
- Albers JJ, Cheung MC (2005). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism.". Curr. Opin. Lipidol. 15 (3): 255–60. doi:10.1097/00041433-200406000-00004. PMID 15166780.
- Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins.". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597.
- Whitmore TE, Day JR, Albers JJ (1996). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1.". Genomics 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104.
- Albers JJ, Wolfbauer G, Cheung MC, et al. (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies.". Biochim. Biophys. Acta 1258 (1): 27–34. PMID 7654777.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Day JR, Albers JJ, Lofton-Day CE, et al. (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.". J. Biol. Chem. 269 (12): 9388–91. PMID 8132678.
- Tu AY, Wolfbauer G, Albers JJ (1996). "Functional characterization of the promoter region of the human phospholipid transfer protein gene.". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hailman E, Albers JJ, Wolfbauer G, et al. (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein.". J. Biol. Chem. 271 (21): 12172–8. doi:10.1074/jbc.271.21.12172. PMID 8647810.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Pussinen PJ, Jauhiainen M, Metso J, et al. (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I.". J. Lipid Res. 39 (1): 152–61. PMID 9469594.
- Jiang XC, D'Armiento J, Mallampalli RK, et al. (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia.". J. Biol. Chem. 273 (25): 15714–8. doi:10.1074/jbc.273.25.15714. PMID 9624168.
- Jauhiainen M, Huuskonen J, Baumann M, et al. (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I.". J. Lipid Res. 40 (4): 654–64. PMID 10191289.
- Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein.". J. Protein Chem. 18 (2): 193–8. doi:10.1023/A:1020628006453. PMID 10333293.
- Lie J, de Crom R, Jauhiainen M, et al. (2002). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins.". Biochem. J. 360 (Pt 2): 379–85. doi:10.1042/0264-6021:3600379. PMC 1222238. PMID 11716766.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Kärkkäinen M, Oka T, Olkkonen VM, et al. (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286.
- Murdoch SJ, Wolfbauer G, Kennedy H, et al. (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement.". J. Lipid Res. 43 (2): 281–9. PMID 11861670.
Lipids: lipoprotein particle metabolism
|
|
Lipoprotein particle classes and subclasses |
- delivery of TGs: Chylomicron
- VLDL
- delivery of C and CE: IDL
- LDL
- lb LDL
- sd LDL
- Lp(a)
- HDL
|
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Apolipoproteins |
- APOA
- APOB
- APOC
- APOD
- APOE
- APOH
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Extracellular enzymes |
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Lipid transfer proteins |
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Cell surface receptors |
- IDL: LRP
- LRP1
- LRP1B
- LRP2
- LRP3
- LRP4
- LRP5
- LRP5L
- LRP6
- LRP8
- LRP10
- LRP11
- LRP12
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ATP-binding cassette transporter |
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
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- Lin HR.Sourcea Department of Chemistry , College of Science, National Kaohsiung Normal University , Taiwan.
- Journal of Asian natural products research.J Asian Nat Prod Res.2013 Jan 3. [Epub ahead of print]
- Paeoniflorin is one of the active ingredients of Paeonia lactiflora Pall., a novel traditional herbal medicine exerting pharmacological effects including antihyperlipidemic, neuroprotective, and anti-hepatofibrosis effects. Liver X receptor (LXR) acts as a ligand-activated transcription factor to ex
- PMID 23281636
- Legionella phospholipases implicated in infection: determination of enzymatic activities.
- Seipel K, Flieger A.SourceDivision of Bacterial Infections (FG11), Robert Koch-Institut, Wernigerode, Germany.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2013;954:355-65. doi: 10.1007/978-1-62703-161-5_22.
- The intracellularly replicating lung pathogen Legionella pneumophila expresses a multitude of different phospholipases which are important virulence tools during host cell infection. To study the lipolytic properties including substrate specificities of potential L. pneumophila phospholipases A (PLA
- PMID 23150408
Japanese Journal
- 2G1510 リン脂質輸送タンパク質Sec14の脂質輸送メカニズムの解明(生体膜・人工膜,口頭発表,日本生物物理学会第50回年会(2012年度))
- Takahashi Chisato,Yamada Makiko,Wakabayashi Masaki,Ishihama Yasushi,Nakano Minoru
- 生物物理 52(SUPPLEMENT_1), S50, 2012-08-15
- NAID 110009584756
- Enzyme oxidase-immobilized phospholipid polymer microparticles for biofuel cell application
- Lin Xiaojie,Konno Tomohiro,Takai Madoka,Ishihara Kazuhiko
- Transactions of the Materials Research Society of Japan 36(3), 531-534, 2011
- … Bioconjugation of enzyme on phospholipid polymer microparticles for the preparation of biofuel cell was investigated in this work. … Amphiphilic phospholipid polymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)-co-p-nitrophenyloxycarbonyl polyethyleneglycol methacrylate (MEONP)-co-vinylferrocene (VFc)) (PMBNF) which has excellent biocompatibility and electron transfer ability, was synthesized by conventional radical polymerization. …
- NAID 130003399013
- Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane(BIOCHEMICAL ENGINEERING)
- Shimanouchi Toshinori,Tasaki Makoto,Vu Huong Thi [他],Ishii Haruyuki,Yoshimoto Noriko,Umakoshi Hiroshi,Kuboi Ryoichi
- Journal of bioscience and bioengineering 109(2), 145-148, 2010-02
- … The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. …
- NAID 110007573244
Related Links
- Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene. Contents. 1 Function; 2 Interactions; 3 Interactive pathway map; 4 References; 5 Further reading. [edit] Function. The protein encoded by this gene is one ...
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