- 関
- phospholipid transfer protein
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/08 02:36:24」(JST)
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| PLTP |
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| Identifiers |
| Aliases |
PLTP, BPIFE, HDLCQ9, phospholipid transfer protein |
| External IDs |
MGI: 103151 HomoloGene: 4536 GeneCards: 5360 |
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| Genetically Related Diseases |
| Disease Name |
References |
| dyslipidemia |
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| Gene ontology |
| Molecular function |
• lipid binding
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| Cellular component |
• extracellular fluid
• extracellular region
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| Biological process |
• high-density lipoprotein particle remodeling
• transport
• sperm motility
• lipid transport
• positive regulation of cholesterol efflux
• vitamin E biosynthetic process
• lipid metabolic process
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| Sources:Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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NM_182676
NM_001242920
NM_001242921
NM_006227
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| RefSeq (protein) |
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NP_001229849.1
NP_001229850.1
NP_006218.1
NP_872617.1
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| Location (UCSC) |
Chr 20: 45.9 – 45.91 Mb |
Chr 2: 164.84 – 164.86 Mb |
| PubMed search |
[2] |
[3] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.
Contents
- 1 Function
- 2 Interactions
- 3 Interactive pathway map
- 4 References
- 5 Further reading
Function
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[4]
Interactions
PLTP has been shown to interact with Apolipoprotein A1[5] and APOA2.[5]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
|px|alt=Statin Pathway edit]]
File:StatinPathway_WP430.png
Statin Pathway edit
- ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
References
- ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_3146&geneId=127431".
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ "Entrez Gene: PLTP phospholipid transfer protein".
- ^ a b Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. PMID 9469594.
Further reading
- Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis". Front. Biosci. 7: d1634–41. doi:10.2741/jiang1. PMID 12086920.
- Albers JJ, Cheung MC (2004). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin. Lipidol. 15 (3): 255–60. doi:10.1097/00041433-200406000-00004. PMID 15166780.
- Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597.
- Whitmore TE, Day JR, Albers JJ (1995). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1". Genomics. 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104.
- Albers JJ, Wolfbauer G, Cheung MC, Day JR, Ching AF, Lok S, Tu AY (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies". Biochim. Biophys. Acta. 1258 (1): 27–34. doi:10.1016/0005-2760(95)00091-p. PMID 7654777.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Day JR, Albers JJ, Lofton-Day CE, Gilbert TL, Ching AF, Grant FJ, O'Hara PJ, Marcovina SM, Adolphson JL (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells". J. Biol. Chem. 269 (12): 9388–91. PMID 8132678.
- Tu AY, Wolfbauer G, Albers JJ (1995). "Functional characterization of the promoter region of the human phospholipid transfer protein gene". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588.
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hailman E, Albers JJ, Wolfbauer G, Tu AY, Wright SD (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein". J. Biol. Chem. 271 (21): 12172–8. doi:10.1074/jbc.271.21.12172. PMID 8647810.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. PMID 9469594.
- Jiang XC, D'Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia". J. Biol. Chem. 273 (25): 15714–8. doi:10.1074/jbc.273.25.15714. PMID 9624168.
- Jauhiainen M, Huuskonen J, Baumann M, Metso J, Oka T, Egashira T, Hattori H, Olkkonen VM, Ehnholm C (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I". J. Lipid Res. 40 (4): 654–64. PMID 10191289.
- Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein". J. Protein Chem. 18 (2): 193–8. doi:10.1023/A:1020628006453. PMID 10333293.
- Lie J, de Crom R, Jauhiainen M, van Gent T, van Haperen R, Scheek L, Jansen H, Ehnholm C, van Tol A (2001). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins". Biochem. J. 360 (Pt 2): 379–85. doi:10.1042/0264-6021:3600379. PMC 1222238. PMID 11716766.
- Kärkkäinen M, Oka T, Olkkonen VM, Metso J, Hattori H, Jauhiainen M, Ehnholm C (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286.
- Murdoch SJ, Wolfbauer G, Kennedy H, Marcovina SM, Carr MC, Albers JJ (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement". J. Lipid Res. 43 (2): 281–9. PMID 11861670.
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Lipids: lipoprotein particle metabolism
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| Lipoprotein particle classes and subclasses |
- delivery of TGs: Chylomicron
- VLDL
- delivery of C and CE: IDL
- LDL
- lb LDL
- sd LDL
- Lp(a)
- HDL
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| Apolipoproteins |
- APOA
- APOB
- APOC
- APOD
- APOE
- APOH
- SAA
|
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| Extracellular enzymes |
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| Lipid transfer proteins |
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| Cell surface receptors |
- IDL: LRP
- LRP1
- LRP1B
- LRP2
- LRP3
- LRP4
- LRP5
- LRP5L
- LRP6
- LRP8
- LRP10
- LRP11
- LRP12
- LDL: LDLR
- LRPAP1
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| ATP-binding cassette transporter |
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UpToDate Contents
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English Journal
- Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease.
- Cavusoglu E1, Marmur JD2, Chhabra S2, Hojjati MR2, Yanamadala S2, Chopra V3, Eng C3, Jiang XC4.
- Atherosclerosis.Atherosclerosis.2015 Apr;239(2):503-8. doi: 10.1016/j.atherosclerosis.2015.02.017. Epub 2015 Feb 16.
- OBJECTIVES: To investigate the long-term prognostic significance of baseline plasma PLTP levels in a group of well-characterized male patients with diabetes mellitus and known or suspected coronary artery disease referred for coronary angiography.BACKGROUND: PLTP is a plasma protein that mediates th
- PMID 25710294
- Phospholipid Transfer Protein Plays a Major Role in the Initiation of Apolipoprotein B-containing Lipoprotein Assembly in Mouse Primary Hepatocytes.
- Manchekar M1, Liu Y1, Sun Z1, Richardson PE2, Dashti N3.
- The Journal of biological chemistry.J Biol Chem.2015 Mar 27;290(13):8196-205. doi: 10.1074/jbc.M114.602748. Epub 2015 Jan 31.
- In this study, we tested the hypothesis that phospholipid transfer protein (PLTP) is a plausible mediator of phospholipid (PL) transfer to the N-terminal 1000 residues of apoB (apoB:1000) leading to the initiation of apoB-containing lipoprotein assembly. To this end, primary hepatocytes from wild ty
- PMID 25638820
- PPAR-β/δ activation promotes phospholipid transfer protein expression.
- Chehaibi K1, Cedó L2, Metso J3, Palomer X4, Santos D2, Quesada H2, Naceur Slimane M5, Wahli W6, Julve J7, Vázquez-Carrera M4, Jauhiainen M3, Blanco-Vaca F8, Escolà-Gil JC9.
- Biochemical pharmacology.Biochem Pharmacol.2015 Mar 15;94(2):101-8. doi: 10.1016/j.bcp.2015.01.016. Epub 2015 Feb 7.
- The peroxisome proliferator-activated receptor (PPAR)-β/δ has emerged as a promising therapeutic target for treating dyslipidemia, including beneficial effects on HDL cholesterol (HDL-C). In the current study, we determined the effects of the PPAR-β/δ agonist GW0742 on HDL composition and the ex
- PMID 25662586
Japanese Journal
- PP-192 腎癌におけるPLTP遺伝子の発現と臨床病理・予後との関係(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
- 矢尾 正祐,黄 エイ,長嶋 洋治,佐野 太,近藤 慶一,槙山 和秀,中井川 昇,塩井 康一,岸田 健,窪田 吉信
- 日本泌尿器科學會雜誌 102(2), 435, 2011-03-20
- NAID 110008612565
- Increased Phospholipid Transfer Protein Activity Associated with the Impaired Cellular Cholesterol Efflux in Type 2 Diabetic Subjects with Coronary Artery Disease
- ATTIA NEBIL,NAKBI AMEL,SMAOUI MAHA,CHAABA RAJA,MOULIN PHILIPPE,HAMMAMI SONIA,HAMDA KHALDOUN BEN,CHANUSSOT FRANCOISE,HAMMAMI MOHAMED
- THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 213(2), 129-137, 2007-10-01
- NAID 10019947321
- Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases
- Yatsuya Hiroshi,Tamakoshi Koji,Hattori Hiroaki,Otsuka Rei,Wada Keiko,Zhang Huiming,Mabuchi Tomoko,Ishikawa Miyuki,Murata Chiyoe,Yoshida Tsutomu,Kondo Takaaki,Toyoshima Hideaki
- Circulation journal : official journal of the Japanese Circulation Society 68(1), 11-16, 2003-12-20
- … Background Phospholipid transfer protein (PLTP) can generate pre-β high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. … The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; … however, little information is available concerning the relationship between PLTP mass and disease. …
- NAID 110002667472
Related Links
- リン脂質転送蛋白質 (PLTP) の生理的意義は？ 抗動脈硬化作用のマーカーとなるか コレステロール逆転送と抗動脈硬化作用 冠動脈疾患の発症メカニズムは未だ明らかになっていません。この冠動脈疾患発症に高 LDL コレステロール ...
- OLTP（オンライントランザクション処理）とは、コンピュータシステムの処理方式の一種で、互いに関連する複数の処理を一体化して確実に実行するトランザクション処理を、端末などからの要求に基づいて即座に実行する方式。OLTP ...
Related Pictures
★リンクテーブル★
[★]
リン脂質輸送タンパク質, PLTP
[★]
- PL配合顆粒
- 総合感冒剤／鎮咳,抗ヒスタミン,解熱配合剤／総合感冒剤
参考
http://www.interq.or.jp/ox/dwm/se/se11/se1180107.html
http://www.info.pmda.go.jp/go/pack/1180107D1131_1_02/
[★]