nodal marginal zone B-cell lymphoma

節性辺縁帯B細胞リンパ腫

WordNet

1. sway gently back and forth, as in a nodding motion; "the flowers were nodding in the breeze"
2. be almost asleep; "The old man sat nodding by the fireplace"
3. let the head fall forward through drowsiness; "The old man was nodding in his chair"
4. the act of nodding the head
5. a sign of assent or salutation or command
6. express or signify by nodding; "He nodded his approval"
7. lower and raise the head, as to indicate assent or agreement or confirmation; "The teacher nodded when the student gave the right answer"
8. regulate housing in; of certain areas of towns (同)district
9. any of the regions of the surface of the Earth loosely divided according to latitude or longitude (同)geographical zone
10. (anatomy) any encircling or beltlike structure (同)zona
11. a locally circumscribed place characterized by some distinctive features
12. an area or region distinguished from adjacent parts by a distinctive feature or characteristic
13. small room in which a monk or nun lives (同)cubicle
14. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
15. a room where a prisoner is kept (同)jail cell, prison cell
16. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
17. any small compartment; "the cells of a honeycomb"
18. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
19. the boundary line or the area immediately inside the boundary (同)border, perimeter
20. the amount of collateral a customer deposits with a broker when borrowing from the broker to buy securities (同)security deposit
21. an amount beyond the minimum necessary; "the margin of victory"
22. the blank space that surrounds the text on a page; "he jotted a note in the margin"
23. the 2nd letter of the Roman alphabet (同)b
24. the blood group whose red cells carry the B antigen (同)type_B, group B

PrepTutorEJDIC

1. (承諾・あいさつ・合図などで)『うなずく』,会釈する / (眠くて)『こっくりする』,(油断して)うとうとする《+off》 / 〈草木・穂などが〉揺れる / (承諾・あいさつなどで)〈頭〉‘を'『うなずかせる』 / …‘を'うなずいて示す / 《副詞[句]を伴って》〈人〉‘に'うなずいて示す / 《同意・承諾・あいさつ・命令など,また時には拒絶を表して》(…に対する)『うなずき』,『会釈』《+『to』+『名』》;(眠気による)こっくり
2. (何らかの目的・特徴などによって他の地域と区別された)『地帯』,地域,地区(belt, area) / (気候によって地球を大別した)帯(たい) / 《米》(交通・郵便などの)同一料金区域;(郵便番号で分けた)郵便区 / (環状の)ベルト,輪,帯 / …‘を'地帯(地区)に分ける / (…の目的に)〈地域〉‘を'区画規制する《+名+as(for)+名》 / …‘を'帯で巻く,‘に'帯印をつける
3. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
4. 『へり』,『縁』,端(edge) / (ページの)『余白』,欄外 / (可能の)限界,限度 / (空間・時間・経費・活動などの)余裕,余地 / 利ざや,マージン,販売利益

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/30 16:51:43」(JST)

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B-cell lymphoma
Classification and external resources
Micrograph showing a large B cell lymphoma. Field stain.
ICD-10	C85.1
ICD-O:	9680/0, 9699/3, 9699/3
MeSH	D016393

The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph glands. They develop more frequently in older adults and in immunocompromised individuals.

B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkins lymphomas. They are often divided into indolent (slow-growing) lymphomas and aggressive lymphomas. Indolent lymphomas respond rapidly to treatment and are kept under control (in remission) with long-term survival of many years, but are not cured. Aggressive lymphomas usually require intensive treatments, but have good prospects for a permanent cure.

Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade. Treatment includes radiation and chemotherapy. Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-reoccurrence. Early-stage aggressive disease is treated with chemotherapy and often radiation, with a 70-90% cure rate. Late-stage indolent lymphomas are sometimes left untreated and monitored until they progress. Late-stage aggressive disease is treated with chemotherapy, with cure rates of over 70%.

Types

Micrograph showing Hodgkin lymphoma, a type of B cell lymphoma that is usually considered separate from other B cell lymphomas. Field stain.

There are numerous kinds of lymphomas involving B cells. The most commonly used classification system is the WHO classification, a convergence of more than one, older classification systems.

Common

Five account for nearly three out of four patients with non-Hodgkin lymphoma:

• Diffuse large B cell lymphoma (DLBCL)
• Follicular lymphoma
• Marginal zone lymphoma (MZL) or Mucosa-Associated Lymphatic Tissue lymphoma (MALT)
• Small cell Lymphocytic lymphoma (overlaps with Chronic lymphocytic leukemia)
• Mantle cell lymphoma (MCL)

Rare

The remaining nine are much less common:

• Burkitt lymphoma
• Primary mediastinal (thymic) large B-cell lymphoma
• Waldenström macroglobulinemia
• Nodal marginal zone B cell lymphoma (NMZL)
• Splenic marginal zone lymphoma (SMZL)
• Intravascular large B-cell lymphoma
• Primary effusion lymphoma
• Lymphomatoid granulomatosis
• T cell/histiocyte-rich large B-cell lymphoma
• Primary diffuse large B-cell lymphoma of the CNS (Central Nervous System)
• Primary cutaneous diffuse large B-cell lymphoma, leg type (Primary cutaneous DLBCL, leg type)
• EBV positive diffuse large B-cell lymphoma of the elderly
• Diffuse large B-cell lymphoma associated with inflammation
• Intravascular large B-cell lymphoma
• ALK-positive large B-cell lymphoma
• Plasmablastic lymphoma
• Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
• Primary effusion lymphoma
• B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
• B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

Other

Additionally, some researchers separate out lymphomas that appear result from other immune system disorders, such as AIDS-related lymphoma.

Classic Hodgkin's lymphoma and nodular lymphocyte predominant Hodgkin's lymphoma are now considered forms of B-cell lymphoma.

Associated chromosomal translocations

Chromosomal translocations involving the immunoglobulin heavy locus (IGH@) is a classic cytogenetic abnormality for many B-cell lymphomas, including follicular lymphoma, mantle cell lymphoma and Burkitt's lymphoma. In these cases, the immunoglobulin heavy locus forms a fusion protein with another protein that has pro-proliferative or anti-apoptotic abilities. The enhancer element of the immunoglobulin heavy locus, which normally functions to make B cells produce massive production of antibodies, now induces massive transcription of the fusion protein, resulting in excessive pro-proliferative or anti-apoptotic effects on the B cells containing the fusion protein. In Burkitt's lymphoma and mantle cell lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1 (on chromosome 11), respectively, which gives the fusion protein pro-proliferative ability. In follicular lymphoma, the fused protein is Bcl-2 (on chromosome 18), which gives the fusion protein anti-apoptotic abilities.

See also

• Richter's transformation
• T-cell lymphoma

References

External links

• Overview and video at harvard.edu
• Lymphoma Association – Specialist UK charity providing free information and support to patients, their families, friends and carers

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 節外（MALT）および節性濾胞辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of extranodal malt and nodal marginal zone lymphomas
• 2. 辺縁帯（MALT）リンパ腫の治療 treatment of marginal zone malt lymphoma
• 3. 脾辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of splenic marginal zone lymphoma
• 4. 造血腫瘍の分類 classification of the hematopoietic neoplasms
• 5. 濾胞性リンパ腫の臨床症状、病理学的特徴、診断、および予後 clinical manifestations pathologic features diagnosis and prognosis of follicular lymphoma

English Journal

• Hematopathology: LC14-1 SMALL B-CELL LYMPHOMAS. DIAGNOSIS OF MALIGNANT LYMPHOMAS IN 2014.

• Quintanilla-Fend L.
• Pathology.Pathology.2014 Oct;46 Suppl 2:S21. doi: 10.1097/01.PAT.0000454121.05599.b8.
• The 2008 WHO classification of tumors of hematopoietic and lymphoid tissues has adopted consensus guidelines for the definition of well-defined entities. The major principle of the classification is the recognition of distinct diseases according to a combination of morphology, immunophenotype, genet
• PMID 25188095

• MYD88 L265P mutation analysis helps define nodal lymphoplasmacytic lymphoma.

• Hamadeh F1, MacNamara SP1, Aguilera NS2, Swerdlow SH3, Cook JR1.
• Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.Mod Pathol.2014 Sep 12. doi: 10.1038/modpathol.2014.120. [Epub ahead of print]
• The diagnosis of lymphoplasmacytic lymphoma is often challenging, especially in extramedullary tissues where the differential diagnosis includes nodal marginal zone lymphoma, splenic marginal zone lymphoma, or other small B-cell neoplasms with plasmacytic differentiation. The MYD88 L265P mutation ha
• PMID 25216226
• PMID 25252788

Japanese Journal

• Composite Follicular Lymphoma and CD5-Positive Nodal Marginal Zone Lymphoma

• Journal of Clinical and Experimental Hematopathology 56(1), 55-58, 2016
• NAID 130005158794

• Nodal Marginal Zone Large B-Cell Lymphoma with Burkitt Translocation and Complex Chromosomal Changes Associated with Overexpression of BCL2, MYC, and BCL6

• Journal of Clinical and Experimental Hematopathology 55(3), 175-180, 2015
• NAID 130005119609

• 低悪性度リンパ腫:―治療の進歩とその課題―

• 臨床血液 56(10), 2039-2046, 2015
• NAID 130005103272

Related Links

• Nodal Marginal Zone Lymphoma - Lymphoma Information ...

Nodal Marginal Zone Lymphoma (NMZL) is an indolent B-cell lymphoma that is found mostly in the lymph nodes. The disease is rare and only accounts for 1% of all Non-Hodgkin’s Lymphomas (NHL). It is most commonly diagnosed ...

• Marginal Zone Lymphoma - Lymphoma Research Foundation

Nodal marginal zone lymphoma (sometimes called monocytoid B-cell lymphoma) occurs within the lymph nodes and accounts for about two percent of all B-cell lymphomas. Splenic marginal zone lymphoma occurs most often in ...

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★リンクテーブル★

リンク元	「節性辺縁帯B細胞リンパ腫」
拡張検索	「extranodal marginal zone B-cell lymphoma of MALT」「extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue」
関連記事	「B」「margin」「nodal」「zone」「marginal」

「節性辺縁帯B細胞リンパ腫」

　　[★]

英

nodal marginal zone B-cell lymphoma

「extranodal marginal zone B-cell lymphoma of MALT」

　　[★] MALT関連節外性辺縁帯B細胞リンパ腫

「extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue」

　　[★] MALT関連節外性辺縁帯B細胞リンパ腫

「B」

　　[★]

• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

　 　

「margin」

　　[★]

• n.

• 縁、周縁部、周辺部分、余分、余裕、限度、マージン

関

additional、brim、edge、extent、extra、limit、limitation、marginally、rim、room

　 　 　 　 　

「nodal」

　　[★]

• adj.

• 結節性の、結節状の、結節型の、節の

関

clause、ganglia、ganglion、ganglionic、knot、node、nodosity、nodular、section、tophaceous、tubercular、varicose

　

「zone」

　　[★]

• n.

• ゾーン、帯域、帯、地帯

関

band、cingulum、marginal、zona、zonae、zonal

　 　 　 　 　 　

「marginal」

　　[★]

• adj.

• 辺縁性の、辺縁の、帯域の

関

border、zone