WordNet

cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue" (同)alter, modify
become different in some particular way, without permanently losing ones or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarkets selection of vegetables varies according to the season" (同)alter, vary
exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares" (同)exchange, commute, convert
a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage"
change clothes; put on different clothes; "Change before you go to the opera"
coins of small denomination regarded collectively; "he had a pocketful of change"
money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver"
remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens"
the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change"
the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains"
undergo a change; become different in essence; losing ones or its original nature; "She changed completely as she grew older"; "The weather changed last night"
a different or fresh set of clothes; "she brought a change in her overnight bag"
a thing that is different; "he inspected several changes before selecting one"
the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election"
an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago" (同)alteration, modification
made or become different in some respect; "hes an altered (or changed) man since his election to Congress"
changed in constitution or structure or composition by metamorphism; "metamorphic rocks"
made or become different in nature or form; "changed attitudes"; "changed styles of dress"; "a greatly changed country after the war"
marked by continuous change or effective action (同)ever-changing

PrepTutorEJDIC

(…に)…'を'『変える』,改める《+『名』+『into』+『名』》 / …'を'『取り替える』,交換する / 〈小切手・為替〉'を'現金にする,〈金〉'を'両替えする;(…に)…'を'両替する《+『名』+『into』+『名』》 / (…に)『変わる』,変化する《+『to』(『into』)+『名』》 / (他の衣服に)着替える《+『into』+『名』》 / (…に)乗り換える《+『to』+『名』》 / 〈C〉(…の)『変化』,移り変わり,変遷《+『of』+『名』》 / 〈C〉(…の)『取り替え』,交換;乗り換え《+『of』+『名』》 / 〈U〉釣り銭,小銭

UpToDate Contents

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1. アルツハイマー病の疫学、病理、および病因 epidemiology pathology and pathogenesis of alzheimer disease
2. 大脳皮質基底核変性症 corticobasal degeneration
3. 成人における微小変化群の病因、臨床的特徴、および診断 etiology clinical features and diagnosis of minimal change disease in adults
4. 成人における微小変化群の治療 treatment of minimal change disease in adults
5. 微小変化群の亜型：メサンギウム増殖、IgM腎症、C1q腎症 minimal change variants mesangial proliferation igm nephropathy c1q nephropathy

English Journal

Neprilysin gene transfer: A promising therapeutic approach for Alzheimer's disease.

Li Y1, Wang J1, Zhang S2, Liu Z1.
Journal of neuroscience research.J Neurosci Res.2015 Sep;93(9):1325-9. doi: 10.1002/jnr.23564. Epub 2015 Jun 11.
Alzheimer's disease (AD) is characterized by widespread neurodegeneration throughout the association cortex and limbic system, deposition of amyloid-β (Aβ) in the neuropil and around blood vessels, and formation of neurofibrillary tangles. Aβ accumulation is considered the major pathological chan
PMID 26096375

Cerebrospinal fluid biomarkers for Alzheimer's disease: current limitations and recent developments.

Zetterberg H1.
Current opinion in psychiatry.Curr Opin Psychiatry.2015 Jul 2. [Epub ahead of print]
PURPOSE OF REVIEW: To give perspectives on current limitations and recent developments in the field of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD).RECENT FINDINGS: Three CSF biomarkers for the neuropathological hallmarks of Alzheimer's disease, namely total tau (T-tau), phospho
PMID 26147615

The diffeomorphometry of regional shape change rates and its relevance to cognitive deterioration in mild cognitive impairment and Alzheimer's disease.

Tang X1, Holland D, Dale AM, Younes L, Miller MI; Alzheimer's Disease Neuroimaging Initiative.
Human brain mapping.Hum Brain Mapp.2015 Jun;36(6):2093-117. doi: 10.1002/hbm.22758. Epub 2015 Feb 3.
We proposed a diffeomorphometry-based statistical pipeline to study the regional shape change rates of the bilateral hippocampus, amygdala, and ventricle in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with healthy controls (HC), using sequential magnetic resonance imaging (
PMID 25644981

Japanese Journal

Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease

HARAGUCHI Takashi,TERADA Seishi,ISHIZU Hideki,SAKAI Kenichi,TANABE Yasuyuki,NAGAI Taiji,TAKATA Hiroshi,NOBUKUNI Keigo,IHARA Yuetsu,KITAMOTO Tetsuyuki,KURODA Shigetoshi
Neuropathology : official journal the Japanese Society of Neuropathology 29(4), 454-459, 2009-08-01
NAID 10028191795

Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease

Kobayashi Katsuji,Nakano Hiroyuki,Hayashi Masahiro,Shimazaki Masao,Fukutani Yuken,Sasaki Kazuo,Sugimori Kaoru,Koshino Yoshifumi
Journal of the Neurological Sciences 208, 17-24, 2003-04-00
… Several factors have been postulated as causes or triggers of cellular apoptotic change. … This study focused on a quantifiable relationship between phosphorylation sites of tau protein in the neurofibrillary tangles (NFT) and neuronal apoptosis. … Five monoclonal anti-tau antibodies (AT180, AT8, HT7, Tau2 and Tau5) for NFT labeling and TdT-mediated UTP nick-end labeling (TUNEL) for localizing apoptotic change were employed. …
NAID 120000809365

神経細胞変性における微小管結合蛋白質タウのリン酸化および代謝に関する研究(平成14年度麻布大学公的研究助成金事業研究成果報告)

村山洋,岩橋和彦,松田基夫,ムラヤマオホシ,イワハシカズヒコ,マツダモトオ,Ohoshi Murayama,Kazuhiko Iwahashi,Motoo Matsuda
麻布大学雑誌 5/6, 129-131, 2002-00-00
神経原線維変化の形成に重要な関わりを持つタウタンパク質の2つの型のアイソフォーム(3リピートタウと4リピートタウ)の識別を可能にする抗体T3RおよびT4Rを得た。今回作製した抗体は,他のグループが作成したものと比較して特異性が高いことに加え,タウの微小菅結合領域の高次構造の変化を検出するのに利用可能であることが明らかとなった。微小管結合領域はタウの機能に重要な部分であり,抗体T3RおよびT4Rは痴 …
NAID 110004323684