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1. 進行性核上性麻痺（PSP） progressive supranuclear palsy psp
2. アルツハイマー病の疫学、病理、および病因 epidemiology pathology and pathogenesis of alzheimer disease
3. 大脳皮質基底核変性症 corticobasal degeneration
4. レビー小体型認知症の疫学、病理学、および病因 epidemiology pathology and pathogenesis of dementia with lewy bodies
5. アルツハイマー病の遺伝学 genetics of alzheimer disease

English Journal

mTor mediates tau localization and secretion: Implication for Alzheimer's disease.

Tang Z1, Ioja E2, Bereczki E2, Hultenby K3, Li C2, Guan Z4, Winblad B2, Pei JJ5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jul;1853(7):1646-57. doi: 10.1016/j.bbamcr.2015.03.003. Epub 2015 Mar 17.
Abnormally hyperphosphorylated tau aggregates form paired helical filaments (PHFs) in neurofibrillary tangles, a key hallmark of Alzheimer's disease (AD) and other tauopathies. The cerebrospinal fluid (CSF) levels of soluble total tau and phospho-tau from clinically diagnosed AD patients are signifi
PMID 25791428

Brinkmalm A1, Portelius E2, Öhrfelt A2, Brinkmalm G2, Andreasson U2, Gobom J2, Blennow K2, Zetterberg H3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jul;1854(7):769-778. doi: 10.1016/j.bbapap.2015.01.009. Epub 2015 Jan 22.
Alzheimer's disease (AD) is a progressive brain amyloidosis that injures brain regions involved in memory consolidation and other higher brain functions. Neuropathologically, the disease is characterized by accumulation of a 42 amino acid peptide called amyloid β (Aβ42) in extracellular senile pla
PMID 25619854

[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.

Harada R1, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
European journal of nuclear medicine and molecular imaging.Eur J Nucl Med Mol Imaging.2015 Jun;42(7):1052-61. doi: 10.1007/s00259-015-3035-4. Epub 2015 Mar 20.
PURPOSE: Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utility of [(18)F]THK-5117 as a highly selective tau imaging radiotracer.METHODS: We initially evalua
PMID 25792456

Frontiers of Model Animals for Neuroscience: Two Prosperous Aging Model Animals for Promoting Neuroscience Research

ITO Koichi
Experimental Animals 62(4), 275-280, 2013
… SAMP10 also shows age-related impairment of learning and memory, but it does not seem to correspond to Alzheimer's disease because senile plaques primarily composed of amyloid β or neurofibrillary tangles primarily composed of phosphorylated tau were not observed. …
NAID 130003382710

リンク元	「神経原線維」
拡張検索	「Alzheimer neurofibrillary change」「Alzheimer's neurofibrillary tangle」「neurofibrillary change」「neurofibrillary tangle」