microsomal triglyceride transfer protein

ミクロゾームトリグリセリド転移タンパク質

WordNet

1. move from one place to another; "transfer the data"; "transmit the news"; "transfer the patient to another hospital"
2. the act of transfering something from one form to another; "the transfer of the music from record to tape suppressed much of the background noise" (同)transference
3. transferring ownership (同)transference
4. application of a skill learned in one situation to a different but similar situation (同)transfer of training, carry-over
5. someone who transfers or is transferred from one position to another; "the best student was a transfer from LSU" (同)transferee
6. a ticket that allows a passenger to change conveyances
7. change from one vehicle or transportation line to another; "She changed in Chicago on her way to the East coast" (同)change
8. transfer somebody to a different position or location of work (同)reassign
9. move around; "transfer the packet from his trouser pockets to a pocket in his jacket" (同)shift
10. transfer from one place or period to another; "The ancient Greek story was transplanted into Modern America" (同)transpose, transplant
11. cause to change ownership; "I transferred my stock holdings to my children"
12. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
13. glyceride occurring naturally in animal and vegetable tissues; it consists of three individual fatty acids bound together in a single large molecule; an important energy source forming much of the fat stored by the body
14. of or relating to microsomes

PrepTutorEJDIC

1. (…から…へ)〈人・物〉‘を'『移す』,移転させる,乗り換えさせる《+名〈人・物〉+from+名+to+名》 / (…から…へ)〈権利・財産など〉‘を'譲り渡す,移転する《+名〈権利・財産〉+from+名+to+名》 / 〈絵画・デザインなど〉‘を'写す,転写する / 〈人が〉(ある人・場所から他の人・場所などへ)『移る』,移される;転任する,転任させられる《+from+名+to+名》 / (…から…へ)列車(バスなど)を乗り換える《+from+名+to+名》 / 〈U〉〈C〉(…を)『移すこと』,(…が)移転されること《+of+名》;転任,転校 / 〈C〉移る人(物),移される人(物);転校生,転任者 / 〈C〉乗り換え切符 / 〈C〉乗り換え場所 / 〈C〉写し絵
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/08 04:31:17」(JST)

wiki en

[Wiki en表示]

Microsomal triglyceride transfer protein
Identifiers
Symbols	MTTP ; ABL; MTP
External IDs	OMIM: 157147 MGI: 106926 HomoloGene: 212 ChEMBL: 2569 GeneCards: MTTP Gene
Gene ontology Molecular function • lipid transporter activity • lipid binding • apolipoprotein binding • protein heterodimerization activity Cellular component • endoplasmic reticulum lumen • rough endoplasmic reticulum • Golgi apparatus • basolateral plasma membrane • brush border membrane • microvillus membrane • membrane-bounded vesicle • receptor complex Biological process • protein lipidation • lipid metabolic process • triglyceride metabolic process • lipid transport • lipoprotein metabolic process • cholesterol homeostasis • lipoprotein transport • small molecule metabolic process • response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4547	17777
Ensembl	ENSG00000138823	ENSMUSG00000028158
UniProt	P55157	O08601
RefSeq (mRNA)	NM_000253	NM_001163457
RefSeq (protein)	NP_000244	NP_001156929
Location (UCSC)	Chr 4: 100.48 – 100.55 Mb	Chr 3: 138.09 – 138.14 Mb
PubMed search	[1]	[2]

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Apoprotein B48 on chylomicra and Apoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Statin Pathway edit||]]

File:StatinPathway_WP430.png

Statin Pathway edit

Pharmacology

Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

• Lomitapide (Juxtapid) was approved by the US FDA for adjunctive treatment of homozygous familial hypercholesterolemia.
• Dirlotapide (Slentrol) and mitratapide (Yarvitan) are veterinary drugs for the management of obesity in dogs.

References

Further reading

• Luz JM, Lennarz WJ (1996). "Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum.". EXS 77: 97–117. doi:10.1007/978-3-0348-9088-5_7. PMID 8856971. 
• Wetterau JR, Lin MC, Jamil H (1997). "Microsomal triaglyceride transfer protein.". Biochim. Biophys. Acta 1345 (2): 136–50. doi:10.1016/s0005-2760(96)00168-3. PMID 9106493. 
• Gordon DA (1997). "Recent advances in elucidating the role of the microsomal triaglyceride transfer protein in apolipoprotein B lipoprotein assembly.". Curr. Opin. Lipidol. 8 (3): 131–7. doi:10.1097/00041433-199706000-00002. PMID 9211060. 
• Ye J (2007). "Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus". PLoS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMC 1959368. PMID 17784784. 
• Wetterau JR, Aggerbeck LP, Bouma ME et al. (1992). "Absence of microsomal triaglyceride transfer protein in individuals with abetalipoproteinemia". Science 258 (5084): 999–1001. doi:10.1126/science.1439810. PMID 1439810.  CS1 maint: Explicit use of et al. (link)
• Sharp D, Ricci B, Kienzle B et al. (1994). "Human microsomal triaglyceride transfer protein large subunit gene structure". Biochemistry 33 (31): 9057–61. doi:10.1021/bi00197a005. PMID 7545943.  CS1 maint: Explicit use of et al. (link)
• Shoulders CC, Narcisi TM, Read J et al. (1995). "The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain". Nat. Struct. Biol. 1 (5): 285–6. doi:10.1038/nsb0594-285. PMID 7664034.  CS1 maint: Explicit use of et al. (link)
• Hagan DL, Kienzle B, Jamil H, Hariharan N (1994). "Transcriptional regulation of human and hamster microsomal triaglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators". J. Biol. Chem. 269 (46): 28737–44. PMID 7961826. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Sharp D, Blinderman L, Combs KA et al. (1993). "Cloning and gene defects in microsomal triaglyceride transfer protein associated with abetalipoproteinaemia". Nature 365 (6441): 65–9. doi:10.1038/365065a0. PMID 8361539.  CS1 maint: Explicit use of et al. (link)
• Narcisi TM, Shoulders CC, Chester SA et al. (1996). "Mutations of the Microsomal Triglyceride-Transfer–Protein Gene in Abetalipoproteinemia". Am. J. Hum. Genet. 57 (6): 1298–310. PMC 1801399. PMID 8533758.  CS1 maint: Explicit use of et al. (link)
• Rehberg EF, Samson-Bouma ME, Kienzle B et al. (1997). "A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triaglyceride transfer protein that prevents complex formation with protein disulfide isomerase". J. Biol. Chem. 271 (47): 29945–52. doi:10.1074/jbc.271.47.29945. PMID 8939939.  CS1 maint: Explicit use of et al. (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  CS1 maint: Explicit use of et al. (link)
• Linnik KM, Herscovitz H (1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898. 
• Bradbury P, Mann CJ, Köchl S et al. (1999). "A common binding site on the microsomal triaglyceride transfer protein for apolipoprotein B and protein disulfide isomerase". J. Biol. Chem. 274 (5): 3159–64. doi:10.1074/jbc.274.5.3159. PMID 9915855.  CS1 maint: Explicit use of et al. (link)
• Wang J, Hegele RA (2000). "Microsomal triaglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia". Hum. Mutat. 15 (3): 294–5. doi:10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E. PMID 10679949. 

UpToDate Contents

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English Journal

• Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats.

• Wu Z1,2, Gao T1, Zhong R3, Lin Z1,2, Jiang C1,2, Ouyang S4,5, Zhao M5, Che C5, Zhang J2, Yin Z1,5.
• Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):712-721. doi: 10.1080/13880209.2016.1267231.
• PMID 28140736

• Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes.

• Swift LL1,2, Love JD1, Harris CM1, Chang BH3, Jerome WG1.
• PloS one.PLoS One.2017 Aug 9;12(8):e0181046. doi: 10.1371/journal.pone.0181046. eCollection 2017.
• PMID 28793320

• Relationship between Amphipathic β Structures in the β1 Domain of Apolipoprotein B and the Properties of the Secreted Lipoprotein Particles in McA-RH7777 Cells.

• Manchekar M, Kapil R, Sun Z, Segrest JP1, Dashti N.
• Biochemistry.Biochemistry.2017 Aug 8;56(31):4084-4094. doi: 10.1021/acs.biochem.6b01174. Epub 2017 Jul 28.
• PMID 28702990

Japanese Journal

• Novel Findings for the Development of Drug Therapy for Various Liver Diseases : Liver Microsomal Triglyceride Transfer Protein Activator May Be a Possible Therapeutic Agent in Non-alcoholic Steatohepatitis

• FUJITA Koji,IMAJO Kento,SHINOHARA Yoshiyasu,NOZAKI Yuichi,WADA Koichiro,YONEDA Masato,ENDO Hiroki,TAKAHASHI Hirokazu,ABE Yasunobu,INAMORI Masahiko,SHIMAMURA Takeshi,KOBAYASHI Noritoshi,KIRIKOSHI Hiroyuki,KUBOTA Kensuke,SAITO Satoru,NAKAJIMA Atsushi
• Journal of pharmacological sciences 115(3), 270-273, 2011-03-20
• … However, very-low-density lipoprotein (VLDL) synthesis, especially hepatic microsomal triglyceride transfer protein (MTP) mRNA expression, was impaired in the NASH group. … MTP is one of the enzymes that transfer triglycerides to nascent apolipoprotein B, producing VLDL and removing lipid from the hepatocyte. …
• NAID 10029892362

• Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis

• YONEDA Masato,FUJITA Koji,IMAJO Kento,MAWATARI Hironori,KIRIKOSHI Hiroyuki,SAITO Satoru,NAKAJIMA Atsushi
• Journal of gastroenterology 46(3), 415-416, 2011-03-01
• NAID 10029028169

Related Links

• MTTP - microsomal triglyceride transfer protein - Genetics ...

The official name of this gene is “microsomal triglyceride transfer protein.” MTTP is the gene's official symbol. The MTTP gene is also known by other names, listed below. Read more about gene names and symbols on ...

• Regulation of microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein (MTP) facilitates the transport of dietary and endogenous fat by the intestine and liver by assisting in the assembly and secretion of triglyceride-rich apolipoprotein B-containing ...

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★リンクテーブル★

リンク元	「ミクロゾームトリグリセリド転移タンパク質」「ミクロソームトリグリセリド輸送タンパク質」「MTP」「MTP gene」
拡張検索	「microsomal triglyceride transfer protein gene」
関連記事	「transfer」「microsomal」「triglycerides」「triglyceride」

「ミクロゾームトリグリセリド転移タンパク質」

　　[★]

英

microsomal triglyceride transfer protein, MTP

同

ミクロソームトリグリセリド輸送タンパク質

[show details]

ミクロゾームトリグリセリド転移タンパク質 : 23 件
ミクロソームトリグリセリド輸送タンパク質 : 21 件
ミクロゾームトリグリセリド転移タンパク : 3 件
ミクロソームトリグリセリド輸送タンパク : 15 件
ミクロゾームトリグリセリド転移蛋白質 : 6 件
ミクロソームトリグリセリド輸送蛋白質 : 18 件
ミクロゾームトリグリセリド転移蛋白 : 21 件
ミクロソームトリグリセリド輸送蛋白 : 3 件
ミクロゾームトリグリセリド転送タンパク質 : 0 件
ミクロゾームトリグリセリド転送タンパク : 1 件
ミクロゾームトリグリセリド転送蛋白質 : 2 件
ミクロゾームトリグリセリド転送蛋白 : 10 件

• 肝細胞でリポタンパク生成に関与する膜結合タンパク質

「ミクロソームトリグリセリド輸送タンパク質」

　　[★]

英

microsomal triglyceride transfer protein MTP

[show details]

ミクロソームトリグリセリド輸送タンパク質 : 22 件
ミクロソームトリグリセリド輸送タンパク : 20 件
ミクロソームトリグリセリド輸送蛋白質 : 11 件
ミクロソームトリグリセリド輸送蛋白 : 9 件
ミクロゾームトリグリセリド輸送タンパク質 : nothing
ミクロゾームトリグリセリド輸送タンパク : nothing
ミクロゾームトリグリセリド輸送蛋白質 : 
ミクロゾームトリグリセリド輸送蛋白 : nothing

「MTP」

　　[★]

• ミクロソームトリグリセリド輸送タンパク質 microsomal triglyceride transfer protein
• 中足指節関節 metatarsophalangeal joint

「MTP gene」

　　[★] microsomal triglyceride transfer protein

「microsomal triglyceride transfer protein gene」

　　[★] ミクロソームトリグリセリド輸送タンパク質遺伝子

「transfer」

　　[★]

• n.

• 伝達、移動、転移、移行、(医療)移植

• v.

• 伝達する、移動する、移行させる、移植する、移す、トランスファーする

関

communication、convey、dissemination、engraft、engraftment、entry、graft、grafting、immigration、implant、implantation、metastases、metastasis、metastasize、migrate、move、movement、run、shift、transduce、transduction、transductional、transference、transit、transition、transitional、translocate、translocation、transmission、transmit、transplant、transplantation、travel

　 　 　 　 　 　 　 　 　 　 　 　

「microsomal」

　　[★]

• adj.

• ミクロソームの

関

microsome

　

「triglycerides」

　　[★] トリアシルグリセロール TG

「triglyceride」

　　[★] トリアシルグリセロール