ionizing radiation injury

電離放射線障害

WordNet

1. any physical damage to the body caused by violence or accident or fracture etc. (同)hurt, harm, trauma
2. an act that causes someone or something to receive physical damage
3. wrongdoing that violates anothers rights and is unjustly inflicted
4. an accident that results in physical damage or hurt (同)accidental injury
5. the spontaneous emission of a stream of particles or electromagnetic rays in nuclear decay (同)radioactivity
6. energy that is radiated or transmitted in the form of rays or waves or particles
7. the act of spreading outward from a central source
8. a radial arrangement of nerve fibers connecting different parts of the brain
9. the spread of a group of organisms into new habitats

PrepTutorEJDIC

1. 『負傷』,『損害』,損傷 / (名誉などを)傷つけること,侮辱《+『to』+『名』》
2. 〈U〉(光・熱・放射能などの)発散,放射 / 〈C〉放射物;放射線;輻射(ふくしゃ)熱 / 〈C〉(喜び・幸福感などの)発散《+『of』+『名』》 / =radioactivity

UpToDate Contents

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• 1. 放射線療法誘発性肺障害 radiation induced lung injury
• 2. 小児における放射線被曝の臨床的特徴 clinical features of radiation exposure in children
• 3. 成人における放射線障害の生物学および臨床的特徴 biology and clinical features of radiation injury in adults
• 4. 画像検査の放射線関連リスク radiation related risks of imaging studies
• 5. 成人における放射線障害の治療 treatment of radiation injury in the adult

English Journal

• Regulation of microglia development and homeostasis.

• Greter M, Merad M.SourceInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland. greter@immunology.uzh.ch.
• Glia.Glia.2013 Jan;61(1):121-7. doi: 10.1002/glia.22408. Epub 2012 Aug 27.
• Microglia represent the resident macrophages of the central nervous system (CNS) and account for 10% of the adult glial cell population in the normal brain. Although microglial cells are thought to contribute to most pathological conditions including CNS infections, neuroinflammatory lesions, brain
• PMID 22927325

• Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury.

• Azzam EI, Jay-Gerin JP, Pain D.SourceDepartment of Radiology, UMDNJ - New Jersey Medical School Cancer Center, Newark, NJ 07103, United States. Electronic address: azzamei@umdnj.edu.
• Cancer letters.Cancer Lett.2012 Dec 31;327(1-2):48-60. doi: 10.1016/j.canlet.2011.12.012. Epub 2011 Dec 17.
• Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target macromolecules or via products of water radiolysis. Further, the oxidative damage may spread from the targeted to neighboring, non-targeted bystander cel
• PMID 22182453

Japanese Journal

• Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity

• Kawakatsu Miho,Urata Yoshishige,Goto Shinji,Ono Yusuke,Li Tao-Sheng
• Journal of Radiation
• … Because there is increasing evidence that ionizing radiation induces the release of reactive oxygen species (ROS) and inflammatory cytokines, we examined the protective effects of a placental extract against radiation injury. … C57BL/6 mice were exposed to 1 Gy of γ-ray radiation every day for 5 days, and placental extract (1 mg/day) was administrated orally soon after each exposure. …
• NAID 120005231145

• Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity

• MASUDA Yuji,KAMIYA Kenji
• International journal of hematology 95(3), 239-245, 2012-03-01
• NAID 10030551664

• Mitigation of Ionizing Radiation-induced Bone Marrow Suppression by p38 Inhibition and G-CSF Administration

• LI Deguan,WANG Yueying,WU Hongying [他],LU Lu,ZHANG Heng,CHANG Jianhui,ZHAI Zhibin,ZHANG Junling,WANG Yong,ZHOU Daohong,MENG Aimin
• Journal of radiation
• … p38 mitogen-activated protein kinases (p38) has been shown to be activated in hematopoietic stem and progenitors cells after exposure to ionizing radiation (IR) and its activation has been implicated in bone marrow (BM) suppression under various pathological conditions. … These findings suggest that the combined therapy with SB and G-GSF is more effective in mitigating TBI-induced acute BM injury than either agent alone. …
• NAID 10029652836

Related Links

• ionizing radiation injury - definition of ionizing radiation injury ...

ionizing radiation injury Etymology: Gk, ion, going; L, radiare, to shine, injuria damage or ill effects suffered by exposure to ionizing radiation, including cellular harm resulting from radiation for diagnostic or therapeutic application. The ...

• ionizing radiation injury -- Encyclopedia Britannica

ionizing radiation injury, also called radiation sickness , tissue destruction or changes caused by deeply penetrating electromagnetic waves of high frequency or subatomic particles that form positively and negatively charged particles ...

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★リンクテーブル★

リンク元	「放射線障害」
関連記事	「injury」「radiation」

「放射線障害」

　　[★]

英

radiation damage, radiation injury, radiation hazard

同

放射能症、電離放射線障害 radiolesion ionizing radiation injury、放射線の危険性 radiation risk

関

放射線、放射能、放射性核種

全身被爆の症状と予後 RNT.322

全身被爆線量	前駆症状(%)	潜伏時間	死因	症状	死亡率(%)
～2	0～50	>3 hr		無症状～軽度の血球現象	0～10
2～10	100	0.5-3 hr	骨髄死	血球現象→感染、出血	0～90
10～20	100	0.5 hr	消化管死	嘔吐・下痢・吐血・下血・脱水	90～100
50	100	several min.	中枢神経死	脳浮腫→けいれん、意識障害	100
*前駆症状：悪心、嘔吐、めまい、全身倦怠感、発熱

• 末梢の血球への影響はリンパ球＞その他の白血球＞血小板＞赤血球

SUB 449

身体的影響	早期障害	骨髄抑制、嘔吐、下痢、下血、放射線宿酔	確定的影響(閾値有り)
		皮膚紅斑・潰瘍、脱毛
		不妊、脳浮腫
	晩期影響	白内障、胎児奇形
遺伝的影響		白血病、癌	確率低影響(閾値無し)
	染色体異常など

メモ

111018

• 放射線による慢性的な障害は、ふくしまの件では微々たるものなのでは？
• 大気汚染、喫煙、飲酒による健康への障害の方が遙かに大きい。
• 問題は、放射線への知識が貧弱すぎること(いわゆる文系馬鹿のマスコミが煽る)と、放射線を積極的に回避しづらいことである。
• 例えば、大気汚染は外出を控えることで避けられるし、喫煙は吸わないこと、副流煙を吸わないことで回避できる。飲酒は飲まなければよい。
• しかし、放射線からは距離を置く、放射性同位体を含む物を摂取しないことしか回避できない。
• しかも、どれだけ体内被曝することで、どれだけ生命予後に影響を及ぼすかは不明である。
• 政府が基準値を定めているが、その値は次々と変更され、疑心暗鬼を生じる原因となってしまった。

「injury」

　　[★]

• n.

• 傷害、損傷、外傷、受傷
• wound or trauma; harm or hurt; usually applied to damage inflicted on the body by an external force.

関

damage、injure、insult、lesion、spoilage、trauma、traumatic、traumatic injury、wound

　 　 　 　 　

「radiation」

　　[★]

• n.

• 放射、放射線
• 放射物
• 輻射、放熱