免疫グロブリン重鎖遺伝子

WordNet

unusually great in degree or quantity or number; "heavy taxes"; "a heavy fine"; "heavy casualties"; "heavy losses"; "heavy rain"; "heavy traffic"
a serious (or tragic) role in a play
an actor who plays villainous roles
slowly as if burdened by much weight; "time hung heavy on their hands" (同)heavily
requiring or showing effort; "heavy breathing"; "the subject made for labored reading" (同)labored, laboured
lacking lightness or liveliness; "heavy humor"; "a leaden conversation" (同)leaden
darkened by clouds; "a heavy sky" (同)lowering, sullen, threatening
slow and laborious because of weight; "the heavy tread of tired troops"; "moved with a lumbering sag-bellied trot"; "ponderous prehistoric beasts"; "a ponderous yawn" (同)lumbering, ponderous
(of sleep) deep and complete; "a heavy sleep"; "fell into a profound sleep"; "a sound sleeper"; "deep wakeless sleep" (同)profound, sound, wakeless
full and loud and deep; "heavy sounds"; "a herald chosen for his sonorous voice" (同)sonorous
full of; bearing great weight; "trees heavy with fruit"; "vines weighed down with grapes" (同)weighed down
(of an actor or role) being or playing the villain; "Iago is the heavy role in `Othello"
(physics, chemistry) being or containing an isotope with greater than average atomic mass or weight; "heavy hydrogen"; "heavy water"
dense or inadequately leavened and hence likely to cause distress in the alimentary canal; "a heavy pudding"
large and powerful; especially designed for heavy loads or rough work; "a heavy truck"; "heavy machinery"
made of fabric having considerable thickness; "a heavy coat"
marked by great psychological weight; weighted down especially with sadness or troubles or weariness; "a heavy heart"; "a heavy schedule"; "heavy news"; "a heavy silence"; "heavy eyelids"
of comparatively great physical weight or density; "a heavy load"; "lead is a heavy metal"; "heavy mahogany furniture"
of great intensity or power or force; "a heavy blow"; "the fighting was heavy"; "heavy seas"
of relatively large extent and density; "a heavy line"
of the military or industry; using (or being) the heaviest and most powerful armaments or weapons or equipment; "heavy artillery"; "heavy infantry"; "a heavy cruiser"; "heavy guns"; "heavy industry involves large-scale production of basic products (such as steel) used by other industries"
sharply inclined; "a heavy grade"
fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

PrepTutorEJDIC

『重い』,重量のある / (分量・程度・規模・強さなどが)『激しい』,大きい, / 『厳しい』,耐えがたい,つらい / 悲しい,陰気な / (動作が)のろい,ぎこちない / ものうい,だるい / (空が)曇った,うっとうしい,(海が)荒れた / (食物が)消化の悪い / 敵役,悪役
『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
遺伝子

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1. 原発性中枢神経系リンパ腫の臨床症状、病理学的特徴、および診断 clinical presentation pathologic features and diagnosis of primary central nervous system lymphoma
2. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
3. 濾胞性リンパ腫の病理生物学 pathobiology of follicular lymphoma
4. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma
5. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia

English Journal

A novel diagnostic biosensor for distinguishing immunoglobulin mutated and unmutated types of chronic lymphocytic leukemia.

Ensafi AA1, Amini M2, Rezaei B2, Talebi M3.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Mar 15;77:409-15. doi: 10.1016/j.bios.2015.09.063. Epub 2015 Sep 30.
In chronic lymphocytic leukemia (CLL), the immunoglobulin heavy-chain variable (IgVH) region may be mutated (Ig-mutated CLL) or unmutated (Ig-unmutated CLL); and the presence or absence of mutations in this region of CLL cells distinguishes two clinically distinct forms. It is important for physicia
PMID 26436328

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

Minnich M1, Tagoh H1, Bönelt P1, Axelsson E1, Fischer M1, Cebolla B1, Tarakhovsky A2, Nutt SL3,4, Jaritz M1, Busslinger M1.
Nature immunology.Nat Immunol.2016 Jan 18. doi: 10.1038/ni.3349. [Epub ahead of print]
The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target genes. Blimp-1 promoted the migration and adhesion of plasmablasts. It directly repressed genes encoding several tran
PMID 26779602

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

Starnes LM1, Su D1, Pikkupeura LM1, Weinert BT2, Santos MA3, Mund A1, Soria R1, Cho YW4, Pozdnyakova I5, Kubec Højfeldt M1, Vala A5, Yang W6, López-Méndez B5, Lee JE4, Peng W6, Yuan J7, Ge K4, Montoya G8, Nussenzweig A3, Choudhary C2, Daniel JA1.
Genes & development.Genes Dev.2016 Jan 15;30(2):149-63. doi: 10.1101/gad.268797.115. Epub 2016 Jan 7.
Class switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B-cell genome. Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transactivat
PMID 26744420

Japanese Journal

B-Cell Prolymphocytic Leukemia Carrying t(8;14)(q24;q32), Associated with Both Autoimmune Hemolytic Anemia and Pure Red Cell Aplasia

, , , ,
Journal of Clinical and Experimental Hematopathology 54(3), 219-224, 2014
… G-banding and fluorescence in situ hybridization using c-MYC and immunoglobulin heavy-chain (IgH) gene probe revealed that leukemia cells carried the t(8;14)(q24;q32)/c-MYC-IgH fusion gene, and breakage and reunion occurred within the non-coding region of c-MYC exon 1 as well as the α switch region of IgH. …
NAID 130004705269

肺転移巣より診断しえた胞巣状軟部肉腫の 1 例

島田ゆうか,三宅真司,五百部浩昭,長嶋洋治,松林純,大城久,池田徳彦,長尾俊孝
日本臨床細胞学会雑誌 53(1), 28-34, 2014
… また, 免疫細胞化学的には transcription factor for immunoglobulin heavy-chain enhancer3 (TFE3) が異型細胞の核に陽性であった. …
NAID 130004513229

成人T細胞白血病・リンパ腫とびまん性大細胞型B細胞リンパ腫の複合リンパ腫

西田有毅,百名洋平,藤澤聖,山野裕二郎,大島孝一,樋口雅一
臨床血液 54(11), 2062-2067, 2013
症例は68歳男性。左背部痛，全身のリンパ節腫大が出現し入院。高カルシウム血症，抗HTLV-1抗体陽性を認めた。左頚部リンパ節生検では，中～大型のCD4陽性異型T細胞の他に，一部大型のEBER・CD20陽性B細胞を認めた。また，HTLV-1 proviral DNAのモノクローナルな組み込み，免疫グロブリンH鎖・T細胞受容体γ鎖遺伝子の再構成を同一リンパ節検体に認め，成人T細胞白血病・リンパ腫(AT …
NAID 130004920530