WordNet

made of lead; "a leaden weight"
(of movement) slow and laborious; "leaden steps" (同)plodding
made heavy or weighted down with weariness; "his leaden arms"; "weighted eyelids" (同)weighted
tend to or result in; "This remark lead to further arguments among the guests"
a soft heavy toxic malleable metallic element; bluish white when freshly cut but tarnishes readily to dull grey; "the children were playing with lead soldiers" (同)Pb, atomic number 82
(sports) the score by which a team or individual is winning
the angle between the direction a gun is aimed and the position of a moving target (correcting for the flight time of the missile)
thin strip of metal used to separate lines of type in printing (同)leading
mixture of graphite with clay in different degrees of hardness; the marking substance in a pencil (同)pencil lead
a position of leadership (especially in the phrase `take the lead'
an advantage held by a competitor in a race; "he took the lead at the last turn"
the playing of a card to start a trick in bridge; "the lead was in the dummy"
a news story of major importance (同)lead story
the introductory section of a story; "it was an amusing lead-in to a very serious matter" (同)lead-in, lede
evidence pointing to a possible solution; "the police are following a promising lead"; "the trail led straight to the perpetrator" (同)track, trail
(baseball) the position taken by a base runner preparing to advance to the next base; "he took a long lead off first"
travel in front of; go in advance of others; "The procession was headed by John" (同)head
take somebody somewhere; "We lead him to our chief"; "can you take me to the main entrance?"; "He conducted us to the palace" (同)take, direct, conduct, guide
be ahead of others; be the first; "she topped her class every year" (同)top
cause to undertake a certain action; "Her greed led her to forge the checks"

PrepTutorEJDIC

鉛の;鉛製の / 鉛色の / (鉛のように)重い,重苦しい,鈍い,陰うつな
《方向を表す副詞[句]を伴って》…‘を'『導く』,案内する / 〈道・灯火などが〉…‘に'道筋を示す;(…へ)…‘を'導く《+『名』+『to』(『into』)+『名』》 / …‘の'先頭になる,1番である / …‘の'『率いる』,指揮する / 〈ある人生・生活〉‘を'経験する,生きる,送る / 『先頭に立つ』,(競技・成績などで)リードスル / 〈人が〉『案内する』,先導する / (…に)〈道などが〉『通じている』《+『to』+『名』》 / (…の)結果となる《+『to』+『名』(do『ing』)》 / 〈U〉《the~》『先頭』,首位 / 〈C〉《a~》相手を引き離した点(時間,距離) / 〈C〉模範,手本(example) / 〈C〉(問題解決の)手がかり,ヒント(clue) / 〈C〉(劇・映画などの)主役,主演俳優 / 〈C〉(新聞報道記事などの本文の前におく要約した)前文,前書き,リード / 先頭の,主要な
〈U〉『鉛』(化学記号はは『pb』) / 〈C〉鉛のおもり,測鉛 / 〈C〉《複数形で》(ガラスをはめる)鉛の枠(わく);《英》(屋根をふくのに用いる)鉛板 / 〈U〉〈C〉黒鉛,鉛筆のしん / 〈U〉《集合的に》(鉛の)弾丸 / …‘に'鉛をかぶせる,鉛を詰める,鉛のおもりを付ける

UpToDate Contents

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1. 成人におけるうつ病治療としてのモノアミン酸化酵素阻害剤（MAOI） monoamine oxidase inhibitors maois for treating depressed adults
2. 成人における双極性障害：評価および診断 bipolar disorder in adults assessment and diagnosis
3. 成人における単極性大うつ病：電気けいれん療法（ECT）の適応および有効性 unipolar major depression in adults indications for and efficacy of electroconvulsive therapy ect
4. 小児および思春期における双極性障害：評価および診断 bipolar disorder in children and adolescents assessment and diagnosis
5. 成人における単極性うつ病 unipolar depression in adults clinical features

English Journal

Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression.

Milaneschi Y1, Lamers F2, Bot M2, Drent ML3, Penninx BW2.
Biological psychiatry.Biol Psychiatry.2015 Nov 17. pii: S0006-3223(15)00951-8. doi: 10.1016/j.biopsych.2015.10.023. [Epub ahead of print]
BACKGROUND: Obesity-related dysregulation of leptin signaling (e.g., hyperleptinemia due to central functional resistance) may affect mood. However, evidence for leptin dysregulation in major depressive disorder (MDD) is conflicting. Inconclusive findings may be attributable to heterogeneity of MDD,
PMID 26742925

Atypical features in depression: Association with obesity and bipolar disorder.

Łojko D1, Buzuk G2, Owecki M3, Ruchała M3, Rybakowski JK4.
Journal of affective disorders.J Affect Disord.2015 Oct 1;185:76-80. doi: 10.1016/j.jad.2015.06.020. Epub 2015 Jun 22.
OBJECTIVES: Depression with atypical features amounts to a significant proportion of depressed patients. Studies have shown its association with bipolarity and, recently, with obesity. In this study, we investigated atypical features of depression in relation to overweight/obesity in three diagnosti
PMID 26148463

Iranian Common Attitude Toward Opium Consumption.

Zarghami M1.
Iranian journal of psychiatry and behavioral sciences.Iran J Psychiatry Behav Sci.2015 Jun;9(2):e2074. doi: 10.17795/ijpbs2074. Epub 2015 Jun 23.
Iran is suffering from the 2(nd) most severe addiction to opioids in the world. While the explanation of this enormous drug problem is refutably related to drug trafficking, the drug dilemma also illustrates the chain reaction of the imposed war with Iraq in 1980 - 88; the problems of poverty, unemp
PMID 26288642

Locomotor micro-activities associated with therapeutic responses in patients with seasonal affective disorders.

Ohashi K1, Yamamoto Y2, Teicher MH1.
Integrative medicine international.Integr Med Int.2015 Apr;1(3):151-161. Epub 2015 Feb 11.
BACKGROUND: Psychomotor retardation, leaden paralysis and fatigue are often used to describe patients with depressive disorders. However, there is limited understanding of their meaning and how they are objectively manifested in the physical world. Patients with seasonal affective disorder (SAD) are
PMID 27135034

Japanese Journal

『学び合い』をリードする学習者に関する研究

野口雄一,西川純
臨床教科教育学会誌 9(1), 35-59, 2009
NAID 40016752642

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

HUME A. N.
Traffic 3, 193-202, 2002
NAID 30013470077

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes

PROVANCE D. W.
Traffic 3, 124-132, 2002
NAID 30013470071

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