WordNet
- mark with lines; "sorrow had lined his face"
- a length (straight or curved) without breadth or thickness; the trace of a moving point
- a single frequency (or very narrow band) of radiation in a spectrum
- reinforce with fabric; "lined books are more enduring"
- a particular kind of product or merchandise; "a nice line of shoes" (同)product line, line of products, line of merchandise, business line, line of business
- the road consisting of railroad track and roadbed (同)railway line, rail line
- a commercial organization serving as a common carrier
- acting in conformity; "in line with"; "he got out of line"; "toe the line"
- something (as a cord or rope) that is long and thin and flexible; "a washing line"
- a conceptual separation or distinction; "there is a narrow line between sanity and insanity" (同)dividing_line, demarcation, contrast
- a formation of people or things one behind another; "the line stretched clear around the corner"; "you must wait in a long line at the checkout counter"
- a formation of people or things one beside another; "the line of soldiers advanced with their bayonets fixed"; "they were arrayed in line of battle"; "the cast stood in line for the curtain call"
- a fortified position (especially one marking the most forward position of troops); "they attacked the enemys line"
- a mark that is long relative to its width; "He drew a line on the chart"
- a spatial location defined by a real or imaginary unidimensional extent
- in games or sports; a mark indicating positions or bounds of the playing area
- persuasive but insincere talk that is usually intended to deceive or impress; "`let me show you my etchings is a rather worn line"; "he has a smooth line but I didnt fall for it"; "that salesman must have practiced his fast line of talk"
- text consisting of a row of words written across a page or computer screen; "the letter consisted of three short lines"; "there are six lines in every stanza"
- be in line with; form a line along; "trees line the riverbank" (同)run along
- cover the interior of; "line the gloves"; "line a chimney"
- fill plentifully; "line ones pockets"
- sing with closed lips; "She hummed a melody"
- a humming noise; "the hum of distant traffic" (同)humming
- be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
- sound with a monotonous hum (同)thrum
- make a low continuous sound; "The refrigerator is humming"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
- characteristic of humanity; "human nature"
- having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
PrepTutorEJDIC
- 『線』,筋,けい / (色・縫い目などの)『線』,しま;(顔・手などの)しわ(wrinkle) / (物・人の)『列』,行列(row) / 『綱』,糸,針金 / 電線,電話線,電信線 / (文章の)『行』;(詩の)『行』 / 《しばしばa~》《話》『短い手紙』(note) / 《複数形で》輪郭,外形(outline) / 境界線(boundary);限界,限度(limit) / (鉄道・バスなどの)路線;航路,空路 / 《複数形で》せりふ / 進路,道順(course);(考えなどの)筋道,方針 / 《しばしばone's~》(活動の)分野,方面;特意 / 家系,血統,血筋 / 在庫商品,仕入れ品 / 導管,パイプライン / 《しばしば複数形で》戦線,防御線 / …‘に'『線を引く』,筋(しま,しわ)をつける / …‘に'『沿って並ぶ;』(…を)…‘に'沿って並べる《+『名』+『with』+『名』》
- (材料で)〈着物など〉‘に'裏を付ける《+『名』『with』+『名』》 / (…で)…‘を'満たす,(…を)…‘に'詰め込む《+『名』+『with』+『名』》
- 〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- (動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
UpToDate Contents
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- 1. 前立腺癌生存者に対するアプローチの概要 overview of approach to prostate cancer survivors
- 2. 去勢抵抗性前立腺癌における化学療法 chemotherapy in castrate resistant prostate cancer
- 3. 進行性前立腺癌における骨転移のマネージメント management of bone metastases in advanced prostate cancer
- 4. 播種性前立腺癌に対する治療の概要 overview of the treatment of disseminated prostate cancer
- 5. 新たに診断された前立腺癌の初回の病期分類および評価 initial staging and evaluation of men with newly diagnosed prostate cancer
English Journal
- Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo.
- Lee JB, Zhang K, Tam YY, Tam YK, Belliveau NM, Sung VY, Lin PJ, Leblanc E, Ciufolini MA, Rennie PS, Cullis PR.SourceDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
- International journal of cancer. Journal international du cancer.Int J Cancer.2012 Sep 1;131(5):E781-90. doi: 10.1002/ijc.27361. Epub 2012 Jan 3.
- The androgen receptor (AR) plays a critical role in the progression of prostate cancer. Silencing this protein using short-hairpin RNA (shRNA) has been correlated with tumor growth inhibition and decreases in serum prostate specific antigen (PSA). In our study, we have investigated the ability of li
- PMID 22095615
- Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells.
- Wiczk A, Hofman D, Konopa G, Herman-Antosiewicz A.AbstractSulforaphane (SFN) is a compound derived from cruciferous plants. Its anticancer properties have been demonstrated both, in cancer cell lines as well as tumors in animal models. It has been shown that SFN inhibits cell proliferation, induces apoptosis, autophagy, and sensitizes cancer cells to therapies. As induction of catabolic processes is often related to perturbation in protein synthesis we aimed to investigate the impact of SFN on this process in PC-3 human prostate cancer cells. In the present study we show that SFN inhibits protein synthesis in PC-3 cells in a dose- and time-dependent manner which is accompanied by a decreased phosphorylation of mTOR substrates. Translation inhibition is independent of mitochondria-derived ROS as it is observed in PC-3 derivatives devoid of functional mitochondrial respiratory chain (Rho0 cells). Although SFN affects mitochondria and slightly decreases glycolysis, the ATP level is maintained on the level characteristic for control cells. Inhibition of protein synthesis might be a protective response of prostate cancer cells to save energy. However, translation inhibition contributes to the death of PC-3 cells due to decreased level of a short-lived protein, survivin. Overexpression of this anti-apoptotic factor protects PC-3 cells against SFN cytotoxicity. Protein synthesis inhibition by SFN is not restricted to prostate cancer cells as we observed similar effect in SKBR-3 breast cancer cell line.
- Biochimica et biophysica acta.Biochim Biophys Acta.2012 Aug;1823(8):1295-305. Epub 2012 May 25.
- Sulforaphane (SFN) is a compound derived from cruciferous plants. Its anticancer properties have been demonstrated both, in cancer cell lines as well as tumors in animal models. It has been shown that SFN inhibits cell proliferation, induces apoptosis, autophagy, and sensitizes cancer cells to thera
- PMID 22640870
Japanese Journal
- Preclinical Safety and Efficacy of in Situ REIC/Dkk-3 Gene Therapy for Prostate Cancer
- Kawauchi Keiichiro,Watanabe Masami,Kaku Haruki,Huang Peng,Sasaki Kasumi,Sakaguchi Masakiyo,Ochiai Kazuhiko,Huh Nam-ho,Nasu Yasutomo,Kumon Hiromi
- Acta Medica Okayama 66(1), 7-16, 2012-02
- … The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. … The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. …
- NAID 120003850603
- IP6含有たいまつ米胚芽発酵液による癌細胞株から分泌される腫瘍関連抗原の抑制
- 池脇 信直,石附 亨,中村 雅彦,高木 隆太郎,金井 美樹,樋口 元剛,近藤 照義
- 九州保健福祉大学研究紀要 12, 189-196, 2011-03
- 本研究では、我々が開発したIP6含有たいまつ米胚芽発酵液(T-IP6)の癌細胞株(MKN-45およびHepG2)から分泌される腫瘍関連抗原(CEAまたはPIVKA-II)に対する影響を化学発光および電気化学発光酵素免疫測定法で解析した。その結果、T-IP6で培養したMKN-45およびHepG2細胞から分泌されるCEAまたはPIVKA-IIは、細胞の形態変化を伴いながら有意に抑制された(P<0 …
- NAID 110008456920
Related Links
- 2. Human Prostate Cancer Cell Lines. Pamela J. Russell and Elizabeth A. Kingsley. 1. Introduction. Prostate cancer affects many men in the West but rarely occurs in Japan or. China. Some epidemiological factors that may be important in this ...
- PC-3 (PC3) human prostate cancer cell lines is one of the cell lines used in prostate cancer research. These cells are useful in investigating the biochemical changes in advanced prostatic cancer cells and in assessing their response to ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ヒト前立腺癌細胞株」 |
| 関連記事 | 「LINE」「line」「human」「cell line」「lining」 |
「ヒト前立腺癌細胞株」
「LINE」
- 日
- 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
- 英
- long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
- 関
- レトロトランスポゾン
- Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.
- The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.
「line」
- n.
- v.
- 裏打ちする
「human」
- n.
- adj.
- ヒトの、ヒト型の
「cell line」
「lining」
- n.