growth hormone binding protein

同

GHBP

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. executed with proper legal authority; "a binding contract"
13. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
14. strip sewn over or along an edge for reinforcement or decoration
15. the capacity to attract and hold something
16. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
17. the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
4. 蛋白(たんばく)質
5. ホルモン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/18 09:41:07」(JST)

wiki en

[Wiki en表示]

growth hormone receptor
Identifiers
Symbol	GHR
Entrez	2690
HUGO	4263
OMIM	600946
RefSeq	NM_000163
UniProt	P10912
Other data
Locus	Chr. 5 p13-p12

Growth hormone-binding protein is a carrier protein for growth hormone.

It is coded by the same gene as growth hormone receptor.

Low levels of Growth Hormone binding protein may indicate a growth hormone receptor problem, and thus a growth hormone insensitivity, rather than a growth hormone deficiency. Normal serum levels of growth hormone Binding Protein 3 may rule out growth hormone insensitivities, like those seen in Laron syndrome.

External links

• somatotropin-binding+protein at the US National Library of Medicine Medical Subject Headings (MeSH)
• Baumann, Gerhard; Shaw, Melissa A.; Winter, Robert J. (1987). "Absence of the Plasma Growth Hormone-Binding Protein in Laron-Type Dwarfism". Journal of Clinical Endocrinology & Metabolism 65 (4): 814–6. doi:10.1210/jcem-65-4-814. PMID 3654924.

UpToDate Contents

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• 1. 慢性腎疾患における成長ホルモン代謝 growth hormone metabolism in chronic kidney disease

English Journal

• Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men.

• Andreassen M1, Jensen RB, Jørgensen N, Juul A.
• European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2014 Mar 8;170(4):555-63. doi: 10.1530/EJE-13-0729. Print 2014 Apr.
• INTRODUCTION: GH activity may be involved in male reproductive function. A common genetic polymorphism in the gene encoding the GH receptor (GHR) results in deletion of the entire exon 3 sequence (GHRd3 isoform). The short GHRd3/d3 isoform seems more sensitive compared with full-length receptors (GH
• PMID 24412931

• Association of serum components of the GH-IGFs-IGFBPs system with GHR-exon 3 polymorphism in normal and idiopathic short stature children.

• Ballerini MG1, Domené HM, Scaglia P, Martínez A, Keselman A, Jasper HG, Ropelato MG.
• Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.Growth Horm IGF Res.2013 Dec;23(6):229-36. doi: 10.1016/j.ghir.2013.08.003. Epub 2013 Aug 19.
• OBJECTIVE: To investigate the possible association of circulating components of GH-IGFs-IGFBPs system with the GHR-exon 3 genotype in normal and idiopathic short stature (ISS) children.DESIGN: Descriptive, cross-sectional study in normal and ISS children.SUBJECTS AND METHODS: 192 normal and 81 ISS c
• PMID 23999134

• siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells.

• Zhou D1, Yang J, Huang WD, Wang J, Zhang Q.
• World journal of gastroenterology : WJG.World J Gastroenterol.2013 Nov 28;19(44):8108-13. doi: 10.3748/wjg.v19.i44.8108.
• AIM: To determine the effects of RNAi-mediated inhibition of the growth hormone receptor (GHR) gene on tumors and colon cancer cells in vivo.METHODS: Construction of a eukaryotic vector for human GHR expression, the pcDNA6.2-GW/EmGFP-small interfering RNAs (siRNAs)-GHR plasmid, was used to inhibit G
• PMID 24307807

Japanese Journal

• Aphidicolin inhibits cell proliferation via the p53-GADD45β pathway in AtT-20 cells

• Kageyama Kazunori,Sugiyama Aya,Murasawa Shingo,Asari Yuko,Niioka Kanako,Oki Yutaka,Daimon Makoto
• Endocrine Journal 62(7), 645-654, 2015
• … Cushing's disease is primarily caused by pituitary corticotroph adenomas, which autonomically secrete adrenocorticotropic hormone (ACTH). … Aphidicolin decreased the phosphorylation of cyclic adenosine monophosphate response element-binding protein and Akt. … Aphidicolin increased the levels of tumor protein 27 (p27) and 53 (p53), while it decreased cyclin E levels. …
• NAID 130005089856

• Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls

• Su Pen-Hua,Chen Hsiao-Yen,Chen Suh-Jen [他],Chen Jia-Yuh,Liou Saou-Hsing,Wang Shu-Li
• The Journal of Toxicological Sciences 40(3), 309-319, 2015
• … The objective of this study was to examine the effects of in utero exposure to polychlorinated biphenyls (PCBs) and dioxins (polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/F) on thyroid and growth hormone concentrations and growth in 8-year-old children. … Height, weight, body mass index, and thyroid and growth hormone concentrations were assessed and compared among the different exposure groups. …
• NAID 130005068418

• Aphidicolin inhibits cell proliferation via the p53-GADD45β pathway in AtT-20 cells

• Kageyama Kazunori,Sugiyama Aya,Murasawa Shingo,Asari Yuko,Niioka Kanako,Oki Yutaka,Daimon Makoto
• Endocrine Journal advpub(0), 2015
• … Cushing's disease is primarily caused by pituitary corticotroph adenomas, which autonomically secrete adrenocorticotropic hormone (ACTH). … Aphidicolin decreased the phosphorylation of cyclic adenosine monophosphate response element-binding protein and Akt. … Aphidicolin increased the levels of tumor protein 27 (p27) and 53 (p53), while it decreased cyclin E levels. …
• NAID 130005066949

Related Links

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• Growth hormone binding protein. The soluble growth hormone ...

1. Minerva Endocrinol. 2002 Dec;27(4):265-76. Growth hormone binding protein. The soluble growth hormone receptor. Baumann G. Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg ...

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★リンクテーブル★

リンク元	「GHBP」
関連記事	「binding」「grow」「binding protein」「growth」

「GHBP」

　　[★]

同

growth hormone binding protein

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「binding protein」

　　[★]

• 結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関

BP、carrier protein、transport protein

「growth」

　　[★]

• n.

• 成長