growth factor receptor-bound protein 2

増殖因子受容体結合タンパク質2、成長因子受容体結合タンパク質2

関

Grb2 adaptor protein

WordNet

1. secured with a cover or binding; often used as a combining form; "bound volumes"; "leather-bound volumes"
2. form the boundary of; be contiguous to (同)border
3. (usually followed by `to' (同)destined
4. headed or intending to head in a certain direction; often used as a combining form as in `college-bound students; "children bound for school"; "a flight destined for New York" (同)destined
5. bound by an oath; "a bound official"
6. confined by bonds; "bound and gagged hostages"
7. confined in the bowels; "he is bound in the belly"
8. held with another element, substance or material in chemical or physical union
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
27. a concept whose truth can be proved; "scientific hypotheses are not facts"
28. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
29. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. 《副詞[句]を伴って》『はね上がる』,はね飛ぶ,はね返る / 〈心が〉おどる,わくわくする / 『はずみ』,はね返り;『跳躍』
2. 《複数形で》(…の)『境界』,境界線(boundary)《+『of』+『名』》 / 《複数形で》(…の)『限度』,限界,範囲(limits)《+『of』+『名』》 / 《複数形で》領域,管内,区域[内] / 《通例受動態で》〈国など〉‘ど'『境を設する』 / 〈行動・欲望など〉'を'制犬する,押える / 境を設する
3. 《補語にのみ用いて》(…へ)『行く途上にある』;(…)『行きの』《+『for』+『名』》 / 《複合語を作って》「…行きの」の意を表す
4. bindの過去・過去分詞 / 『縛られた』 / 《補語にのみ用いて》《『be bound to』 do》…する『義務がある』 / 《補語にのみ用いて》《『be bound to』 do》『きっと…する』 / 〈本が〉製本された / 《補語にのみ用いて》《米語》《『be bound to』 do》…する決心をしている / 《複合語を作って》「…に縛られた,閉ざされた」の意を表す
5. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
6. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
7. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
8. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/28 22:10:42」(JST)

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[Wiki en表示]

Growth factor receptor-bound protein 2
PDB rendering based on 1gri.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H46, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 3WA4
Identifiers
Symbols	GRB2 ; ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2
External IDs	OMIM: 108355 MGI: 95805 HomoloGene: 1576 ChEMBL: 3663 GeneCards: GRB2 Gene
Gene ontology Molecular function • phosphotyrosine binding • SH3/SH2 adaptor activity • epidermal growth factor receptor binding • neurotrophin TRKA receptor binding • protein binding • SH3 domain binding • protein kinase binding • protein phosphatase binding • identical protein binding • insulin receptor substrate binding • poly(A) RNA binding • ephrin receptor binding Cellular component • nucleus • cytoplasm • endosome • Golgi apparatus • cytosol • plasma membrane • COP9 signalosome • vesicle membrane • extracellular vesicular exosome • Grb2-EGFR complex Biological process • epidermal growth factor receptor signaling pathway • Ras protein signal transduction • cell-cell signaling • axon guidance • aging • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • positive regulation of signal transduction • viral process • platelet activation • positive regulation of actin filament polymerization • T cell costimulation • receptor internalization • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • negative regulation of epidermal growth factor receptor signaling pathway • signal transduction in response to DNA damage • regulation of MAPK cascade • innate immune response • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • anatomical structure formation involved in morphogenesis • leukocyte migration • protein heterooligomerization • branching involved in labyrinthine layer morphogenesis • cellular response to ionizing radiation • positive regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2885	14784
Ensembl	ENSG00000177885	ENSMUSG00000059923
UniProt	P62993	Q60631
RefSeq (mRNA)	NM_002086	NM_008163
RefSeq (protein)	NP_002077	NP_032189
Location (UCSC)	Chr 17: 73.31 – 73.4 Mb	Chr 11: 115.64 – 115.71 Mb
PubMed search	[1]	[2]

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function and expression

Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types, and so it is not surprising that a targeted gene disruption of Grb2 in mouse is lethal at an early embryonic stage. Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap. Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.

Domains

The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference for pY-X-N-X, where X is generally a hydrophobic residue such as valine (see [3]).

The N-terminal SH3 domain binds to proline-rich peptides and can bind to the Ras-guanine exchange factor SOS.

The C-terminal SH3 domain binds to peptides conforming to a P-X-I/L/V/-D/N-R-X-X-K-P motif that allows it to specifically bind to proteins such as Gab-1.

Interactions

Grb2 has been shown to interact with:

• ADAM15,
• Abl gene,
• Arachidonate 5-lipoxygenase,
• B-cell linker,
• BCAR1,
• BCR gene,
• Beta-2 adrenergic receptor,
• C-Met,
• CBLB,
• CD117,
• CD22,
• CD28,
• CDKN1B,
• CRK,
• Cbl gene,
• Colony stimulating factor 1 receptor,
• DCTN1,
• DNM1,
• Dock180,
• Dystroglycan,
• EPH receptor A2,
• ETV6,
• Epidermal growth factor receptor,
• Erythropoietin receptor,
• FRS2,
• Fas ligand,
• GAB1,
• GAB2,
• Glycoprotein 130,
• Granulocyte colony-stimulating factor receptor,
• HER2/neu,
• HNRNPC,
• Huntingtin,
• INPP5D,
• IRS1,
• ITK,
• Janus kinase 1,
• Janus kinase 2,
• KHDRBS1,
• Linker of activated T cells,
• Lymphocyte cytosolic protein 2,
• MAP2,
• MAP3K1
• MAP4K1,
• MED28,
• MST1R,
• MUC1,
• Mitogen-activated protein kinase 9,
• NCKIPSD,
• NEU3,
• PDGFRB,
• PIK3R1,
• PLCG1,
• PRKAR1A,
• PTK2,
• PTPN11,
• PTPN12,
• PTPN1,
• PTPN6,
• PTPRA,
• RAPGEF1,
• RET proto-oncogene,
• SH2B1,
• SH3KBP1,
• SHC1,
• SOS1,
• Src,
• Syk,
• TNK2,
• TrkA,
• VAV1,
• VAV2,
• VAV3, and
• Wiskott-Aldrich syndrome protein.

See also

• MAPK/ERK pathway

References

Further reading

• Colledge M, Froehner SC (1998). "Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.". Ann. N. Y. Acad. Sci. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219. 
• Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP.". Trends Cell Biol. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612. 
• O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP.". Int. J. Biochem. Cell Biol. 31 (3–4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664. 
• Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase.". Prog. Biophys. Mol. Biol. 71 (3–4): 435–78. doi:10.1016/S0079-6107(98)00052-2. PMID 10354709. 
• Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C (2004). "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]". J. Soc. Biol. 198 (2): 133–7. PMID 15368963. 

External links

• GRB2 Adaptor Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
• The Grb2 protein page on The SH2 Website
• GeneCards entry for Grb2
• Human Protein Resource Database entry for Grb2
• Grb2 information on iHOP (Information Hyperlinked over Proteins)
• GRB2 Info with links in the Cell Migration Gateway

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 2. 成長ホルモンの生理学 physiology of growth hormone
• 3. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children
• 4. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
• 5. 腎移植後の慢性腎臓病小児患者に対する成長ホルモン治療 growth hormone treatment in children with chronic kidney disease and postrenal transplantation

English Journal

• SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.

• Liu Y, Chen JB, Zhang M, Zhang XL, Meng JL, Zhou J, Hao ZY, Zhang L, Zu XB, Liang CZ.
• European review for medical and pharmacological sciences. 2019 Apr;23(7)2756-2767.
• Increasing studies reported that the serum- and glucocorticoid-inducible kinases (SGKs) contributed to the tumorigenesis of various cancer. In this article, we are aiming to explore the function of SGK2 in renal cell cancer (RCC). In this study, the SGK2 expression was quantified by Western blot (WB
• PMID 31002126

• Malignant progression of an extraventricular neurocytoma arising from the VIIIth cranial nerve: A case report and literature review.

• Sugita Y, Furuta T, Komaki S, Ohshima K, Sakata K, Morioka M.
• Neuropathology : official journal of the Japanese Society of Neuropathology. 2019 Apr;39(2)120-126.
• A rare case of extraventricular neurocytoma (EVN) arising from the VIIIth cranial nerve in a 34-year-old woman is reported. The patient had a 20-year history of hearing loss and facial palsy. Computed tomography showed a 3-cm enhancing lesion in the left cerebellopontine angle (CPA). At operation, t
• PMID 30588667

• Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor-induced endothelial progenitor cell proliferation and migration.

• Fan Q, Zhang L, Zhu W, Xue S, Song Y, Chang Q.
• PeerJ. 2019 ;7()e6675.
• Grb2-associated binder 1 (Gab1), a scaffolding adaptor protein, plays an important role in transmitting key signals that control cell growth, migration, and function from multiple tyrosine kinase receptors. This study was designed to investigate the influence of upregulation of Gab1 in endothelial p
• PMID 30956905

Japanese Journal

• Expression of Gab1 Is Associated with Poor Prognosis of Patients with Epithelial Ovarian Cancer

• Tohoku J. Exp. Med. 239(3), 177-184, 2016
• NAID 130005157317

• Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR

• Scientific reports 3, 2013-10-09
• NAID 120005348191

• Activated O₂・⁻ and H₂O₂ Mediated Cell Survival in SU11274-Treated Non-Small-Cell Lung Cancer A549 Cells via c-Met-PI3K-Akt and c-Met-Grb2/SOS-Ras-p38 Pathways

• Journal of pharmacological sciences 119(2), 150-159, 2012-06-20
• NAID 10030828482

Related Links

• GRB2 growth factor receptor bound protein 2 [ (human)]

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 ...

• GRB2 - Growth factor receptor-bound protein 2 - Homo ...

Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing ...

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★リンクテーブル★

リンク元	「増殖因子受容体結合タンパク質2」「Grb2 adaptor protein」「成長因子受容体結合タンパク質2」
関連記事	「grow」「fact」「factor」「bound」「growth」

「増殖因子受容体結合タンパク質2」

　　[★]

英

growth factor receptor-bound protein 2、Grb2 adaptor protein

関

成長因子受容体結合タンパク質2、Grb2タンパク質

「Grb2 adaptor protein」

　　[★]

Grb2タンパク質、増殖因子受容体結合タンパク質2

関

growth factor receptor-bound protein 2

「成長因子受容体結合タンパク質2」

　　[★]

英

growth factor receptor-bound protein 2

関

増殖因子受容体結合タンパク質2

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「bound」

　　[★] 　 　 　 　 　 　 　 　 　 　 　 　

「growth」

　　[★]

• n.

• 成長